Synthesis and efficient hepatocyte targeting of galactosylated chitosan as a gene carrier in vitro and in vivo

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 99 B, Issue 1, 2011, Pages 70-80

  Cheng, Mingrong ^a   Li, Qing ^b   Wan, Tao ^c   Hong, Xiaowu ^a   Chen, Houxiang ^c   He, Bing ^a   Cheng, Zhijian ^a   Xu, Hongzhi ^a   Ye, Tao ^a   Zha, Bingbing ^a   Wu, Jingbo ^a   Zhou, Runjiao ^a  

^a FUDAN UNIVERSITY   (China)

^b Fudan University   (China)

^c WUHAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

galactosylated chitosan; gene delivery; gene therapy; hepatocyte targeting; transfection efficiency

Indexed keywords

AVERAGE DIAMETER; CANCER CELL LINES; CHARGE RATIO; COLON CANCER; CONTROL GROUPS; ENHANCED GREEN FLUORESCENT PROTEIN; GALACTOSYLATED CHITOSAN; GENE CARRIER; GENE DELIVERY; GENE TRANSFECTION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS; HEPATOCYTE-TARGETING; HEPATOCYTES; IN-VITRO; IN-VIVO; LIPOFECTIN; LIVER METASTASIS; MTT ASSAYS; NATURAL KILLER CELLS; NONVIRAL VECTORS; RECOMBINANT PLASMID; T LYMPHOCYTES; TAIL VEINS; THERAPEUTIC EFFICACY; TRANSFECTION EFFICIENCY; TUMOR TISSUES;

BIOSYNTHESIS; CELL CULTURE; CELLS; CHITOSAN; DISEASES; DNA; EFFICIENCY; FLOW CYTOMETRY; GENE TRANSFER; MAMMALS; NANOPARTICLES; TUMORS;

GENE THERAPY;

CHITOSAN; ENHANCED GREEN FLUORESCENT PROTEIN; GALACTOSYLATED CHITOSAN; INTERLEUKIN 12; LIPOFECTIN; NANOPARTICLE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HETEROZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; SYNTHESIS;

ANIMALS; CELL LINE, TUMOR; CHITOSAN; COLONIC NEOPLASMS; FEMALE; GALACTOSE; GENETIC VECTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEPATOCYTES; INTERLEUKINS; LIVER NEOPLASMS; MATERIALS TESTING; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NANOPARTICLES; RANDOM ALLOCATION; RECOMBINANT FUSION PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 80052306233     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31873     Document Type: Article

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