A risk assessment of human ether-a-go-go-related gene potassium channel inhibition by using lipophilicity and basicity for drug discovery

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 9, 2011, Pages 1110-1116

  Kawai, Yukinori ^a   Tsukamoto, Shinsaku ^a   Ito, Junko ^a   Akimoto, Katsuya ^a   Takahashi, Masayuki ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Basicity; Human ether a go go related gene; Lipophilicity

Indexed keywords

GARENOXACIN; GATIFLOXACIN; GEMIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; POTASSIUM CHANNEL HERG; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ALKALINITY; ARTICLE; DRUG DESIGN; LIPOPHILICITY; PHYSICAL CHEMISTRY; PKA; QT PROLONGATION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LONG QT SYNDROME; QUINOLONES; RISK ASSESSMENT;

EID: 80052282205     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1110     Document Type: Article

References (22)

1. Takasuna K., Chiba K., Manabe S., Biomol. Ther., 17, 1-11 (2009).
2. Waring M. J., Johnstone C., Bioorg. Med. Chem. Lett., 17, 1759-1764 (2007).
3. Aronov A. M., Goldman B. B., Bioorg. Med. Chem., 12, 2307-2315 (2004).
4. Ponti D. F., Poluzzi E., Cavalli A., Recanatini M., Montanaro N., Drug Saf., 25, 263-286 (2002).
5. Milnes J. T., Crociani O., Arcangeli A., Hancox J. C., Witchel H. J., Br. J. Pharmacol., 139, 887-898 (2003).
6. Mitcheson J. S., Chem. Res. Toxicol., 21, 1005-1010 (2008).
7. Aronov A. M., J. Med. Chem., 49, 6917-6921 (2006).
8. Diller J. D., Curr. Comput.-Aided Drug Des., 5, 106-121 (2009).
9. Gleeson P., Bravi G., Modi S., Lowe D., Bioorg. Med. Chem., 17, 5906-5919 (2009).
10. Gleeson M. P., J. Med. Chem., 51, 817-834 (2008).
11. Waring J. M., Expert Opin. Drug Discov., 5, 235-248 (2010).
12. Matasi J. J., Caldwell J. P., Zhang H., Fawzi A., Higgins G. A., Cohen-Williams M. E., Varty G. B., Tulshian D. B., Bioorg. Med. Chem. Lett., 15, 3675-3678 (2005).
13. Fernandez D., Ghanta A., Kauffman G. W., Sanguinetti M. C., J. Biol. Chem., 279, 10120-10127 (2004).
14. Farid R., Day T., Friesner R. A., Pearlstein R. A., Bioorg. Med. Chem., 14, 3160-3173 (2006).
15. Masetti M., Cavalli A., Recanatini M., J. Comput. Chem., 29, 795-808 (2008).
16. Recanatini M., Poluzzi E., Masetti M., Cavalli A., De Ponti F., Med. Res. Rev., 25, 133-166 (2005).
17. Thai K.-M., Ecker G. F., Curr. Med. Chem., 14, 3003-3026 (2007).
18. Aronov A. M., Curr. Opin. Drug Discov. Devel., 11, 128-140 (2008).
19. Johnson S. R., Yue H., Conder M. L., Shi H., Doweyko A. M., Lloyd J., Levesque P., Bioorg. Med. Chem., 15, 6182-6192 (2007).
20. Kuroyanagi J., Kanai K., Sugimoto Y., Horiuchi T., Achiwa I., Takeshita H., Kawakami K., Bioorg. Med. Chem., 18, 7593-7606 (2010).
21. Miyauchi R., Kawakami K., Ito M., Matsuhashi N., Ohki H., Inagaki H., Takahashi H., Takemura M., Bioorg. Med. Chem., 17, 6879-6889 (2009).
22. R Development Core Team: "R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing," Vienna, Austria, 2011. ISBN 3-900051-07-0, URL http://www.R-project.org/.