Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6879-6889

  Miyauchi, Rie ^a   Kawakami, Katsuhiro ^a   Ito, Masao ^a   Matsuhashi, Norikazu ^a   Ohki, Hitoshi ^a   Inagaki, Hiroaki ^a   Takahashi, Hisashi ^a   Takemura, Makoto ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

6 Desfluoro quinolones; Antibacterial agents; Gram positive bacteria; Type II topoisomerases

Indexed keywords

1 (2 FLUOROCYCLOPROPAN 1 YL) 1,4 DIHYDRO 8 METHOXY 7 [3 (1 METHYLAMINOCYCLOPROPAN 1 YL)PYRROLIDIN 1 YL] 4 OXOQUINOLIN 3 CARBOXYLIC ACID; 6 FLUORO 1 (2 FLUOROCYCLOPROPAN 1 YL) 1,4 DIHYDRO 8 METHOXY 7 [3 (1 METHYLAMINOCYCLOPROPAN 1 YL)PYRROLIDIN 1 YL] 4 OXOQUINOLIN 3 CARBOXYLIC ACID; 7 [3 (1 AMINOCYCLOBUTAN 1 YL)PYRROLIDIN 1 YL] 1 (2 FLUOROCYCLOPROPAN 1 YL) 1,4 DIHYDRO 8 METHOXY 4 OXOQUINOLIN 3 CARBOXYLIC ACID; 7 [3 (1 AMINOCYCLOBUTAN 1 YL)PYRROLIDIN 1 YL] 6 FLUORO 1 (2 FLUOROCYCLOPROPAN 1 YL) 1,4 DIHYDRO 8 METHOXY 4 OXOQUINOLIN 3 CARBOXYLIC ACID; 7 [3 (1 AMINOCYCLOPROPYL) 1 PYRROLIDINYL] 1 (2 FLUOROCYCLOPROPYL) 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINECARBOXYLIC ACID; 7[3 (1 AMINOCYCLOPROPAN 1 YL)PYRROLIDIN 1 YL] 6 FLUORO 1 (2 FLUOROCYCLOPROPAN 1 YL) 1,4 DIHYDRO 8 METHOXY 4 OXOQUINOLIN 3 CARBOXYLIC ACID; CIPROFLOXACIN; DALFOPRISTIN PLUS QUINUPRISTIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; GARENOXACIN; GATIFLOXACIN; HABEKACIN; LINEZOLID; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TEICOPLANIN; TROVAFLOXACIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTERIUM ISOLATE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DISEASE MODEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; GRAM POSITIVE BACTERIUM; HOSPITAL INFECTION; IN VITRO STUDY; IN VIVO STUDY; LUNG INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; MONKEY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; SUBSTITUTION REACTION; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

POSIBACTERIA;

EID: 69949131276     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.026     Document Type: Article

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