Endogenous peptide YY and neuropeptide y inhibit colonic ion transport, contractility and transit differentially via Y 1 and Y 2 receptors

British Journal of Pharmacology

Volumn 164, Issue 2 B, 2011, Pages 471-484

  Tough, I R ^a   Forbes, S ^a   Tolhurst, R ^a   Ellis, M ^b   Herzog, H ^c   Bornstein, J C ^b   Cox, H M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

colonic transit; endogenous peptide YY; faecal pellet propulsion; ion transport; neuropeptide Y; PYY mice; tonic antisecretory activity; upper gastrointestinal transit; Y 1 receptor; Y 2 receptor

Indexed keywords

N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE YY; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON SECRETION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; INTESTINE TRANSIT TIME; ION TRANSPORT; MALE; MOUSE; MUSCLE TONE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT CIRCUIT CURRENT; WILD TYPE;

AGED; ANIMALS; COLON; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; INTESTINAL MUCOSA; ION TRANSPORT; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROPEPTIDE Y; PEPTIDE YY; RECEPTORS, NEUROPEPTIDE Y;

EID: 80052249988     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01401.x     Document Type: Article

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