Computational model of the migrating motor complex of the small intestine

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 4 49-4, 2004, Pages

  Thomas, E A ^a   Sjovall H ^b   Bornstein, J C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Enteric nervous system; Motor pattern generation; Neural networks; Recurrent excitation; Synaptic depression; Waves in neural tissue

Indexed keywords

ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; INTESTINE MOTILITY; MIGRATING MYOELECTRIC COMPLEX; NERVE CELL NETWORK; NERVE EXCITABILITY; PATTERN GENERATOR; PRIORITY JOURNAL; SYNAPTIC INHIBITION;

EID: 1642364221     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00369.2003     Document Type: Article

References (47)

1. Bertrand PP, Kunze WA, Bornstein JC, Furness JB, and Smith ML. Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. Am J Physiol Gastrointest Liver Physiol 273: G422-G435, 1997.
2. Bertrand PP, Thomas EA, Kunze WAA, and Bornstein JC. A simple mathematical model of second-messenger mediated slow excitatory postsynaptic potentials. J Comput Neurosci 8: 127-142, 2000.
3. Bornstein JC, Furness JB, Kelly HF, Bywater RAR, Neild TO, and Bertrand PP. A computer simulation of the enteric nervous system. J Auton Nerv Syst 64: 143-157, 1997.
4. Bornstein JC, Furness JB, Kunze WA, and Bertrand PP. Enteric reflexes that influence motility. In: Innervation of the Gastrointestinal Tract, edited by Costa M and Brookes SJ, 2002.
5. Bornstein JC, Hendriks R, Furness JB, and Trussell DC. Ramifications of the axons of AH-neurons injected with the intracellular marker biocytin in the myenteric plexus of the guinea pig small intestine. J Comp Neurol 314: 437-452, 1991.
6. Bornstein JC, North RA, Costa M, and Furness JB. Excitatory synaptic potentials due to activation of neurons with short projections in the myenteric plexus. Neuroscience 11: 723-731, 1984.
7. Brookes S. Retrograde tracing of enteric neuronal pathways. Neurogastroenterol Motil 13: 1-18, 2001.
8. Clerc N, Furness JB, Bornstein JC, and Kunze WA. Correlation of electrophysiological and morphological characteristics of myenteric neurons of the duodenum in the guinea pig. Neuroscience 82: 899-914, 1998.
9. Clerc N, Furness JB, Kunze WAA, Thomas EA, and Bertrand PP. Long-term effects of synaptic activation at low frequency on enteric neurons. Neuroscience 90: 279-289, 1999.
10. Code CF and Marlett JA. The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol 246: 289-309, 1975.
11. Ehrlein HJ, Schemann M, and Siegle ML. Motor patterns of small intestine determined by closely spaced extraluminal transducers and videofluoroscopy. Am J Physiol Gastrointest Liver Physiol 253: G259-G267, 1987.
12. Gabbiani F and Koch C. Principles of spike train analysis. In: Methods in Neuronal Modeling: from Ions to Networks, edited by Segev CKal, 1998.
13. Galligan JJ, Costa M, and Furness JB. Gastrointestinal myoelectric activity in conscious guinea pigs. Am J Physiol Gastrointest Liver Physiol 249: G92-G99, 1985.
14. Grafe P, Mayer CJ, and Wood JD. Synaptic modulation of calcium-dependent potassium conductance in myenteric neurones in the guinea pig. J Physiol 305: 235-248, 1980.
15. Hirst GD, Holman ME, and McKirdy HC. Two descending nerve pathways activated by distension of guinea pig small intestine. J Physiol 244: 113-127, 1975.
16. Hirst GD, Holman ME, and Spence I. Two types of neurones in the myenteric plexus of the duodenum in the guinea pig. J Physiol 236: 303-326, 1974.
17. Hodgkiss JP and Lees GM. Slow intracellular potentials in AH-neurons of the myenteric plexus evoked by repetitive activation of synaptic inputs. Neuroscience 11: 255-261, 1984.
18. Itoh Z, Aizawa I, and Takeuchi S. Neural regulation of interdigestive motor activity in canine jejunum. Am J Physiol Gastrointest Liver Physiol 240: G324-G330, 1981.
19. Jebbink HJ, vanBerge-Henegouwen GP, Akkermans LM, and Smout AJ. Small intestinal motor abnormalities in patients with functional dyspepsia demonstrated by ambulatory manometry. Gut 38: 694-700, 1996.
20. 3 tachykinin receptors in neurons of the rat myenteric plexus. Neuroscience 100: 191-199, 2000.
21. Johnson PJ, Bornstein JC, Yuan SY, and Furness JB. Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea pig ileum. Br J Pharmacol 118: 973-983, 1996.
22. Kellow JE, Borody TJ, Phillips SF, Tucker RL, and Haddad AC. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology 91: 386-395, 1986.
23. Kunze WA, Bertrand PP, Furness JB, and Bornstein JC. Influence of the mucosa on the excitability of myenteric neurons. Neuroscience 76: 619-634, 1997.
24. Kunze WA, Bornstein JC, and Furness JB. Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal. Neuroscience 66: 1-4, 1995.
25. Kunze WA, Furness JB, and Bornstein JC. Simultaneous intracellular recordings from enteric neurons reveal that myenteric AH neurons transmit via slow excitatory postsynaptic potentials. Neuroscience 55: 685-694, 1993.
26. Lieske SP, Thoby-Brisson M, Telgkamp P, and Ramirez JM. Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps. Nat Neurosci 3: 600-607, 2000.
27. Mann PT, Southwell BR, and Furness JB. Internalization of the neurokinin 1 receptor in rat myenteric neurons. Neuroscience 91: 353-362, 1999.
28. Morita K and North RA. Significance of slow synaptic potentials for transmission of excitation in guinea pig myenteric plexus. Neuroscience 14: 661-672, 1985.
29. Morita K, North RA, and Tokimasa T. Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea pig ileum. J Physiol 333: 141-149, 1982.
30. 2 receptors mediate depolarization and presynaptic inhibition in guinea pig enteric nervous system. J Physiol 368: 435-452, 1985.
31. North RA and Tokimasa T. Muscarinic synaptic potentials in guinea pig myenteric plexus neurones. J Physiol 333: 151-156, 1982.
32. Sarna S, Condon RE, and Cowles V. Enteric mechanisms of initiation of migrating myoelectric complexes in dogs. Gastroenterology 84: 814-822, 1983.
33. Sarna S, Stoddard C, Belbeck L, and Mcwade D. Intrinsic nervous control of migrating myoelectric complexes. Am J Physiol Gastrointest Liver Physiol 241: G16-G23, 1981.
34. Sarna SK. Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 89: 894-913, 1985.
35. Sarr MG and Kelly KA. Myoelectric activity of the autotransplanted canine jejunoileum. Gastroenterology 81: 303-310, 1981.
36. Scales JA and Snieder R. What is a wave? Nature 401: 739-740, 1999.
37. Shampine LF. Numerical solution of ordinary differential equations. 1994.
38. Southwell BR, Seybold VS, Woodman HL, Jenkinson KM, and Furness JB. Quantitation of neurokinin 1 receptor internalization and recycling in guinea pig myenteric neurons. Neuroscience 87: 925-931, 1998.
39. Stebbing MJ and Bornstein JC. Electrophysiological mapping of fast excitatory synaptic inputs to morphologically and chemically characterized myenteric neurons of guinea pig small intestine. Neuroscience 73: 1017-1028, 1996.
40. Szurszewski JH. A migrating electric complex of canine small intestine. Am J Physiol 217: 1757-1763, 1969.
41. Thomas EA. A parallel algorithm for simulation of large neural networks. J Neurosci Methods 98: 123-134, 2000.
42. Thomas EA, Bertrand PP, and Bornstein JC. Genesis and role of coordinated firing in a feed forward network-a model study of the enteric nervous system. Neuroscience 93: 1525-1537, 1999.
43. Thomas EA, Bertrand PP, and Bornstein JC. A computer simulation of recurrent, excitatory networks of sensory neurons of the gut in guinea pig. Neurosci Lett 287: 137-140, 2000.
44. Thomas EA and Bornstein JC. Inhibitory cotransmission or after-hyperolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience 120: 333-351, 2003.
45. Thornton PD and Bornstein JC. Slow excitatory synaptic potentials evoked by distension in myenteric descending interneurones of guinea pig ileum. J Physiol 539: 589-602, 2002.
46. Wood JD. Functions of AH/Dogiel II and S/Dogiel I neurons in the enteric microcircuits. In: Advances in the Innervation of the Gastrointestinal Tract, edited by G. E. Holle JDW. Amsterdam: Excerpta Medica, 1992, p. 125-145.
47. Zucker RS and Regehr WG. Short-term synaptic plasticity. Annu Rev Physiol 64: 355-405, 2002.