Neuropeptide Y hyperpolarizes submucosal neurons of the guinea-pig descending colon

Neuroscience Letters

Volumn 227, Issue 3, 1997, Pages 212-214

  Hirai, Keiji ^a,b   Browning, Kirsteen N ^a   Lees, Gordon M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Descending colon; Electrophysiology; Guinea pig; Intracellular recordings; Membrane hyperpolarization; Neuropeptide Y; Submucosal neurone; Y1 receptors

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; IDAZOXAN; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y DERIVATIVE; NEUROPEPTIDE Y RECEPTOR;

ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GUINEA PIG; HYPERPOLARIZATION; INTRACELLULAR RECORDING; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; COLON; ELECTROPHYSIOLOGY; GUINEA PIGS; MALE; MEMBRANE POTENTIALS; NEURONS; NEUROPEPTIDE Y; SUBMUCOUS PLEXUS;

EID: 0030907083     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00325-X     Document Type: Article

References (15)

1. 2 receptors. Biopolymers. 37:1995;123-142.
2. Browning K.N., Cunningham S.M.C., Timmermans J.-P., Lees G.M. Modulation of synaptic transmission in the myenteric plexus of the guinea-pig descending colon. A role for extrinsic neuropeptide Y (NPY) containing fibres? J. Physiol. 495:1996;100P-101P.
3. Cunningham S.M.C., Lees G.M. Neuropeptide Y in submucosal ganglia: regional differences in the innervation of guinea-pig large intestine. J. Autonomic Nerv. Sys. 55:1995;135-145.
4. 2-Receptor-mediated selective inhibition of slow, inhibitory postsynaptic potential in submucous neurons of guinea-pig caecum. Br. J. Pharmacol. 113:1994;883-888.
5. Gehlert D. Subtypes of receptor for neuropeptide Y: implications for the targeting of therapeutics. Life Sci. 55:1994;551-562.
6. 2 receptors in a human neuroblastoma cell line. J. Biol. Chem. 269:1994;8226-8233.
7. 3H]noradrenaline release from rat hypothalamic synaptosomes via different mechanisms. Neurosci. Lett. 188:1995;9-12.
8. 2+ channel currents in human neuroblastoma (SH-SYSY) cells by neuropeptide Y and a novel cyclic neuropeptide Y analogue. Neuropharmacology. 34:1995;1507-1514.
9. Mihara S. Intracellular recordings from neurones of the submucous plexus. Prog. Neurobiol. 40:1993;529-572.
10. Mihara S., Nishi S., North R.A., Surprenant A. A non-cholinergic slow inhibitory post-synaptic potential in neurones of the guinea-pig submucous plexus. J. Physiol. 390:1987;357-365.
11. 2 Receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line. J. Biol. Chem. 269:1994;8842-8848.
12. Surprenant A., Shen K.-Z., North R.A., Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurons. J. Physiol. 431:1990;585-608.
13. Toth P.T., Bindokas V.P., Bleakman D., Colmers W.F., Miller R.J. Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals. Nature. 364:1993;635-639.
14. Wiley J.W., Gross R.A., MacDonald R.L. Agonists for neuropeptide Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents. J. Neurophysiol. 70:1993;324-330.
15. + channels in vascular smooth muscle cells from the rat tail artery. Pflügers Arch. 429:1994;280-284.