Terpyridine platinum(ii) complexes inhibit cysteine proteases by binding to active-site cysteine

Journal of Biomolecular Structure and Dynamics

Volumn 29, Issue 2, 2011, Pages 267-282

  Lo, Yan Chung ^a,b   Su, Wen Chi ^c   Ko, Tzu Ping ^b,d   Wang, Nai Chen ^b,d   Wang, Andrew H J ^a,b,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b Institute of Biological Chemistry   (Taiwan)

^c Institute of Molecular Biology   (Taiwan)

^d National Core Facility of High Throughput Protein Crystallography   (Taiwan)

Author keywords

Crystal structure; Cysteine protease inhibitors; Enzyme activity; Platinum(II)

Indexed keywords

(4 HYDROXYLTHIOPHENOLATO)(2,2':6',2'' TERPYRIDINE)PLATINUM; (N ACETYL 4 AMINOTHIOPHENOLATO)(2,2':6',2'' TERPYRIDINE)PLATINUM; 5 OXOPROLYL PEPTIDASE; ANTINEOPLASTIC METAL COMPLEX; BIPYRIDINE PLATINUM DICHLORIDE; CARBOPLATIN; CISPLATIN; CYSTEINE; CYSTEINE PROTEINASE; PEPTIDASE; PLATINUM COMPLEX; PRYOGLUTAMYL PEPTIDASE 1; TERPYRIDINE PLATINUM CHLORIDE COMPLEX; TERPYRIDINE PLATINUM DICHLORIDE; THIOREDOXIN REDUCTASE 1; TRANSPLATIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

EID: 80052238297     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/073911011010524993     Document Type: Article

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