Transfer of 4′-chloro-2,2′:6′,2″-terpyridine platinum(II) between human serum albumin, glutathione and other thiolate ligands. A possible selective natural transport mechanism for the delivery of platinum(II) drugs to tumour cells

Anti-Cancer Drug Design

Volumn 15, Issue 6, 2000, Pages 431-439

  Ross, S A ^a   Carr, C A ^a   Briet J W ^a   Lowe, G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Drug delivery; Exchange; Selectivity; Thiols

Indexed keywords

4' CHLORO 2,2':6',2'' TERPYRIDINE PLATINUM; ANTINEOPLASTIC AGENT; ANTITRYPANOSOMAL AGENT; CYSTEINE; FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE; HUMAN SERUM ALBUMIN; LIGAND; MERCAPTOETHANOL; PLATINUM DERIVATIVE; RECOMBINANT HUMAN SERUM ALBUMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; THIOACID; THIOL DERIVATIVE; THIOREDOXIN REDUCTASE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG; 2,2' BIPYRIDINE; DRUG DERIVATIVE; PLATINUM COMPLEX; RECOMBINANT PROTEIN; SERUM ALBUMIN;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG PENETRATION; DRUG RETENTION; DRUG SELECTIVITY; DRUG TRANSPORT; ENZYME INHIBITION; HUMAN; INTRACELLULAR TRANSPORT; LIGAND BINDING; METAL BINDING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; CELL CULTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRANSPORT AT THE CELLULAR LEVEL; ULTRAVIOLET SPECTROPHOTOMETRY;

2,2'-DIPYRIDYL; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; GLUTATHIONE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; ORGANOPLATINUM COMPOUNDS; RECOMBINANT PROTEINS; SERUM ALBUMIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFHYDRYL COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0034351135     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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