Hypoxia. cross talk between oxygen sensing and the cell cycle machinery

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 3, 2011, Pages

  Semenza, Gregg L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxia inducible factor; MCM proteins

Indexed keywords

ASPARAGINE; CELL DNA; HELICASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; PROLINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE MACHINERY; CELL HYPOXIA; CELL METABOLISM; CELL PROLIFERATION; CELL TYPE; DNA SYNTHESIS; HOMEOSTASIS; HUMAN; HYDROXYLATION; MAMMAL CELL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; UBIQUITINATION;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL HYPOXIA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXYGEN;

MAMMALIA;

EID: 80052200933     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00176.2011     Document Type: Article

References (25)

1. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E. Role of (HIF) 1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature 394: 485-490, 1998.
2. Corn PG, Ricci MS, Scata KA, Arsham AM, Simon MC, Dicker DT, El-Deiry WS. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther 4: 1285-1294, 2005.
3. Forsburg SL. Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev 68: 109-131, 2004.
4. Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23: 359-369, 2003.
5. Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11: 335-347, 2007.
6. Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X, Warnecke C, Eckardt KU, Wiesener MS. HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle 8: 1386-1395, 2009.
7. Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 10: 509-521, 2002.
8. Holley RW, Kiernan RJ. Contact inhibition of cell division in 3T3 cells. Proc Natl Acad Sci USA 60: 300-304, 1968.
9. Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell 42: 700-712, 2011.
10. Hyrien O, Marheineke K, Goldar A. Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem. Bioessays 25: 116-125, 2003.
11. Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402, 2008.
12. Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. (HIF) 1α induces cell cycle arrest by functionally counteracting Myc. EMBO J 23: 1949-1956, 2004.
13. Kumar GK. Hypoxia. 3. Hypoxia and neurotransmitter synthesis. Am J Physiol Cell Physiol 300: C743-C751, 2011.
14. Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40: 294-309, 2010.
15. Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669, 2005.
16. Miyata T, Takizawa S, van Ypersele de Strihou C. Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets. Am J Physiol Cell Physiol 300: C226-C2231, 2011.
17. Sclafani RA, Holzen TM. Cell cycle regulation of DNA replication. Annu Rev Genet 41: 237-280, 2007.
18. Semenza GL. American Journal of Physiology-Cell Physiology theme: Hypoxia. Am J Physiol Cell Physiol 300: C225, 2011.
19. Semenza GL. Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med 2: 336-361, 2010.
20. Seoane J, Le HV, Massagué J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734, 2002.
21. Shimoda LA, Polak J. Hypoxia. 4. Hypoxia and ion channel function. Am J Physiol Cell Physiol 300: C951-C967, 2011.
22. Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH. DNA replication licensing and human cell proliferation. J Cell Sci 114: 2027-2041, 2001.
23. Wheaton WW, Chandel NS. Hypoxia. 2. Hypoxia regulates cellular metabolism. Am J Physiol Cell Physiol 300: C385-C393, 2011.
24. Yoon D, Ponka P, Prchal JT. Hypoxia. 5. Hypoxia and hematopoiesis. Am J Physiol Cell Physiol 300: C1215-C1222, 2011.
25. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11: 407-420, 2007.