메뉴 건너뛰기




Volumn 22, Issue 17, 2011, Pages 3242-3252

Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; COREPRESSOR PROTEIN; DNA BINDING PROTEIN; MUTANT PROTEIN; NOTCH RECEPTOR; PROTEIN LIN 12; REPRESSOR PROTEIN; SUPPRESSOR OF HAIRLESS PROTEIN; UNCLASSIFIED DRUG;

EID: 80052189609     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-05-0420     Document Type: Article
Times cited : (39)

References (51)
  • 2
    • 0032563941 scopus 로고    scopus 로고
    • Transcriptional control: Repression by local chromatin modification
    • Ashraf SI, Yp YT (1998). Transcriptional control: repression by local chromatin modification. Curr Biol 8, R683-R686. (Pubitemid 28451023)
    • (1998) Current Biology , vol.8 , Issue.19
    • Ashraf, S.I.1    Ip, Y.T.2
  • 3
    • 0036682974 scopus 로고    scopus 로고
    • Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to suppressor of hairless
    • DOI 10.1101/gad.987402
    • Barolo S, Stone T, Bang AG, Posakony JW (2002). Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev 16, 1964-1976. (Pubitemid 34832924)
    • (2002) Genes and Development , vol.16 , Issue.15 , pp. 1964-1976
    • Barolo, S.1    Stone, T.2    Bang, A.G.3    Posakony, J.W.4
  • 5
    • 67650660754 scopus 로고    scopus 로고
    • The Notch signaling pathway:Transcriptional regulation at Notch target genes
    • Borggrefe T, Oswald F (2009). The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci 66, 1631-1646.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1631-1646
    • Borggrefe, T.1    Oswald, F.2
  • 6
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415. (Pubitemid 23214028)
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 7
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling:A simple pathway becomes complex
    • Bray SJ (2006). Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7, 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 8
    • 13344260610 scopus 로고    scopus 로고
    • Bre1 is required for Notch signaling and histone modification
    • DOI 10.1016/j.devcel.2004.11.020, PII S1534580704004575
    • Bray SJ, Musisi H, Bienz M (2005). Bre1 is required for Notch signaling and histone modification. Dev Cell 8, 279-286. (Pubitemid 40197743)
    • (2005) Developmental Cell , vol.8 , Issue.2 , pp. 279-286
    • Bray, S.1    Musisi, H.2    Bienz, M.3
  • 9
    • 0028090045 scopus 로고
    • Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-Jkappa, by direct protein-protein interaction with Drosophila hairless
    • Brou C, Logeat F, Lecourtois M, Vandekerckhove J, Kourilsky P, Schweisguth F, Israel A (1994). Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila Hairless. Genes Dev 8, 2491-2503. (Pubitemid 24323826)
    • (1994) Genes and Development , vol.8 , Issue.20 , pp. 2491-2503
    • Brou, C.1    Logeat, F.2    Lecourtois, M.3    Vandekerckhove, J.4    Kourilsky, P.5    Schweisguth, F.6    Israel, A.7
  • 10
    • 0024284041 scopus 로고
    • Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells
    • Bunch TA, Grinblat Y, Goldstein LS (1988). Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res 16, 1043-1061.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1043-1061
    • Bunch, T.A.1    Grinblat, Y.2    Goldstein, L.S.3
  • 11
    • 38049018580 scopus 로고    scopus 로고
    • Mutational and energetic studies of Notch1 transcription complexes
    • Delbianco C, Aster JC, Blacklow SC (2008). Mutational and energetic studies of Notch1 transcription complexes. J Mol Biol 376, 131-140.
    • (2008) J Mol Biol , vol.376 , pp. 131-140
    • Delbianco, C.1    Aster, J.C.2    Blacklow, S.C.3
  • 12
    • 34548533226 scopus 로고    scopus 로고
    • Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development
    • DOI 10.1016/j.mod.2007.05.002, PII S0925477307000974
    • Doroquez DB, Orr-Weaver TL, Rebay I (2007). Split ends antagonizes the Notch and potentiates the EGFR-signaling pathways during Drosophila eye development. Mech Dev 124, 792-806. (Pubitemid 47385136)
    • (2007) Mechanisms of Development , vol.124 , Issue.9-10 , pp. 792-806
    • Doroquez, D.B.1    Orr-Weaver, T.L.2    Rebay, I.3
  • 13
    • 75149112880 scopus 로고    scopus 로고
    • Thermodynamic and structural insights into CSL-DNA complexes
    • Friedmann DR, Kovall RA (2010). Thermodynamic and structural insights into CSL-DNA complexes. Protein Sci 19, 34-46.
    • (2010) Protein Sci , vol.19 , pp. 34-46
    • Friedmann, D.R.1    Kovall, R.A.2
  • 14
    • 47249090444 scopus 로고    scopus 로고
    • RAM-induced allostery facilitates assembly of a Notch pathway active transcription complex
    • Friedmann DR, Wilson JJ, Kovall RA (2008). RAM-induced allostery facilitates assembly of a Notch pathway active transcription complex. J Biol Chem 283, 14781-14791.
    • (2008) J Biol Chem , vol.283 , pp. 14781-14791
    • Friedmann, D.R.1    Wilson, J.J.2    Kovall, R.A.3
  • 15
    • 0035724485 scopus 로고    scopus 로고
    • Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction
    • DOI 10.1046/j.1432-1327.2001.02387.x
    • Fuchs KP, Bommer G, Dumont E, Christoph B, Vidal M, Kremmer E, Kempkes B (2001). Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction. Eur J Biochem 268, 4639-4646. (Pubitemid 34203412)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.17 , pp. 4639-4646
    • Fuchs, K.P.1    Bommer, G.2    Dumont, E.3    Christoph, B.4    Vidal, M.5    Kremmer, E.6    Kempkes, B.7
  • 16
    • 34848825012 scopus 로고    scopus 로고
    • Gene-Specific Targeting of the Histone Chaperone Asf1 to Mediate Silencing
    • DOI 10.1016/j.devcel.2007.08.021, PII S1534580707003401
    • Goodfellow H, Krejci A, Moshkin Y, Verrijzer CP, Karch F, Bray SJ (2007). Gene-specific targeting of the histone chaperone Asf1 to mediate silencing. Dev Cell 13, 593-600. (Pubitemid 47500809)
    • (2007) Developmental Cell , vol.13 , Issue.4 , pp. 593-600
    • Goodfellow, H.1    Krejci, A.2    Moshkin, Y.3    Verrijzer, C.P.4    Karch, F.5    Bray, S.J.6
  • 17
    • 0027437850 scopus 로고
    • Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    • DOI 10.1016/0092-8674(93)90498-F
    • Gyuris J, Golemis E, Chertkov H, Brent R (1993). Cdi1, a human G1 and S phase protein phosphatase that associates with cdk2. Cell 75, 791-803. (Pubitemid 23346376)
    • (1993) Cell , vol.75 , Issue.4 , pp. 791-803
    • Gyuris, J.1    Golemis, E.2    Chertkov, H.3    Brent, R.4
  • 18
    • 0028988990 scopus 로고
    • Masking of the CBF1/RBPJk transcriptional repression domain by Epstein-Barr virus EBNA2
    • Hsieh JJ, Hayward SD (1995). Masking of the CBF1/RBPJk transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268, 560-563.
    • (1995) Science , vol.268 , pp. 560-563
    • Hsieh, J.J.1    Hayward, S.D.2
  • 19
    • 0031047971 scopus 로고    scopus 로고
    • Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation
    • Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (1997). Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol 71, 1938-1945. (Pubitemid 27078572)
    • (1997) Journal of Virology , vol.71 , Issue.3 , pp. 1938-1945
    • Hsieh, J.J.-D.1    Nofziger, D.E.2    Weinmaster, G.3    Hayward, S.D.4
  • 21
    • 62849112801 scopus 로고    scopus 로고
    • Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation
    • Jin L-H, Choi JJ, Kim B, Cho HA, Kim J, Kim-Ha J, Kim YJ (2009). Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation. Mol Cell Biol 29, 1515-1525.
    • (2009) Mol Cell Biol , vol.29 , pp. 1515-1525
    • Jin, L.-H.1    Choi, J.J.2    Kim, B.3    Cho, H.A.4    Kim, J.5    Kim-Ha, J.6    Kim, Y.J.7
  • 24
    • 0029901697 scopus 로고    scopus 로고
    • Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
    • DOI 10.1038/382133a0
    • Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138. (Pubitemid 26242872)
    • (1996) Nature , vol.382 , Issue.6587 , pp. 133-138
    • Kim, J.1    Sebring, A.2    Esch, J.J.3    Kraus, M.E.4    Vorwerk, K.5    Magee, J.6    Carroll, S.B.7
  • 25
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway:Unfolding the activation mechanism
    • Kopan R, Ilagan MXG (2009). The canonical Notch signaling pathway: Unfolding the activation mechanism. Cell 137, 216-233.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.G.2
  • 26
    • 77956300942 scopus 로고    scopus 로고
    • Mechanistic insights into Notch receptor signaling from structural and biochemical studies
    • Kovall R, Blacklow SJ (2010). Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol 92, 31-71.
    • (2010) Curr Top Dev Biol , vol.92 , pp. 31-71
    • Kovall, R.1    Blacklow, S.J.2
  • 29
    • 0028856308 scopus 로고
    • Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development
    • Lyman DF, Yedvobnick B (1995). Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Genetics 141, 1491-1505.
    • (1995) Genetics , vol.141 , pp. 1491-1505
    • Lyman, D.F.1    Yedvobnick, B.2
  • 30
    • 34248171798 scopus 로고    scopus 로고
    • Hairless, the ignored antagonist of the Notch signalling pathway
    • Maier D (2006). Hairless, the ignored antagonist of the Notch signalling pathway. Hereditas 143, 212-221.
    • (2006) Hereditas , vol.143 , pp. 212-221
    • Maier, D.1
  • 31
    • 46149099570 scopus 로고    scopus 로고
    • The tiny Hairless protein from Apis mellifera:A potent antagonist of Notch signalling in Drosophila melanogaster
    • Maier D, Chen AX, Preiss A, Ketelhut M (2008). The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signalling in Drosophila melanogaster. BMC Evol Biol 8, 175.
    • (2008) BMC Evol Biol , vol.8 , pp. 175
    • Maier, D.1    Chen, A.X.2    Preiss, A.3    Ketelhut, M.4
  • 32
    • 0032745064 scopus 로고    scopus 로고
    • Subcellular localization of Hairless protein shows a major focus of activity within the nucleus
    • DOI 10.1016/S0925-4773(99)00208-7, PII S0925477399002087
    • Maier D, Nagel AC, Johannes B, Preiss A (1999). Subcellular localization of Hairless protein shows a major focus of activity within the nucleus. Mech Dev 89, 195-199. (Pubitemid 29528292)
    • (1999) Mechanisms of Development , vol.89 , Issue.1-2 , pp. 195-199
    • Maier, D.1    Nagel, A.C.2    Johannes, B.3    Preiss, A.4
  • 34
    • 0029047609 scopus 로고
    • Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
    • Matsuno K, Diederich RJ, Go MJ, Blaumüller CM, Artavanis-Tsakonas S (1995). Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121, 2633-2644.
    • (1995) Development , vol.121 , pp. 2633-2644
    • Matsuno, K.1    Diederich, R.J.2    Go, M.J.3    Blaumüller, C.M.4    Artavanis-Tsakonas, S.5
  • 35
    • 0030693878 scopus 로고    scopus 로고
    • Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
    • Matsuno K, Go MJ, Sun XS, Eastman DS, Artavanis-Tsakonas S (1997). Suppressor of Hairless-independent events in Notch signaling imply new pathway elements. Development 124, 4265-4273. (Pubitemid 27496862)
    • (1997) Development , vol.124 , Issue.21 , pp. 4265-4273
    • Matsuno, K.1    Go, M.J.2    Sun, X.3    Eastman, D.S.4    Artavanis-Tsakonas, S.5
  • 36
    • 0035873851 scopus 로고    scopus 로고
    • Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila
    • DOI 10.1016/S0960-9822(01)00224-X
    • Morel V, Lecourtois M, Massiani O, Maier D, Preiss A, Schweisguth F (2001). Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila. Curr Biol 11, 789-792. (Pubitemid 32442798)
    • (2001) Current Biology , vol.11 , Issue.10 , pp. 789-792
    • Morel, V.1    Lecourtois, M.2    Massiani, O.3    Maier, D.4    Preiss, A.5    Schweisguth, F.6
  • 38
    • 27944445286 scopus 로고    scopus 로고
    • Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors
    • DOI 10.1128/MCB.25.23.10433-10441.2005
    • Nagel AC, Krejci A, Tenin G, Bravo-Patiño A, Bray S, Maier D, Preiss A (2005). Hairless mediated repression of Notch target genes requires combined activity of Groucho and CtBP corepressors. Mol Cell Biol 25, 10433-10441. (Pubitemid 41681966)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.23 , pp. 10433-10441
    • Nagel, A.C.1    Krejci, A.2    Tenin, G.3    Bravo-Patino, A.4    Bray, S.5    Maier, D.6    Preiss, A.7
  • 39
    • 0034213518 scopus 로고    scopus 로고
    • Su(H)-independent activity of Hairless during mechano-sensory organ formation in Drosophila
    • DOI 10.1016/S0925-4773(00)00319-1, PII S0925477300003191
    • Nagel AC, Maier D, Preiss A (2000). Su(H) independent activity of Hairless during mechanosensory organ formation in Drosophila. Mech Dev 94, 3-12. (Pubitemid 30332383)
    • (2000) Mechanisms of Development , vol.94 , Issue.1-2 , pp. 3-12
    • Nagel, A.C.1    Maier, D.2    Preiss, A.3
  • 40
    • 33644749306 scopus 로고    scopus 로고
    • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    • DOI 10.1016/j.cell.2005.12.037, PII S009286740600122X
    • Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006). Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124, 973-983. (Pubitemid 43344237)
    • (2006) Cell , vol.124 , Issue.5 , pp. 973-983
    • Nam, Y.1    Sliz, P.2    Song, L.3    Aster, J.C.4    Blacklow, S.C.5
  • 41
    • 33646203458 scopus 로고    scopus 로고
    • Target selectivity of vertebrate notch proteins: Collaboration between discrete domains and CSL-binding site architecture determines activation probability
    • DOI 10.1074/jbc.M506108200
    • Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R (2006). Target selectivity of vertebrate Notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem 281, 5106-5119. (Pubitemid 43847776)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.8 , pp. 5106-5119
    • Ong, C.-T.1    Cheng, H.-T.2    Chang, L.-W.3    Ohtsuka, T.4    Kageyama, R.5    Stormo, G.D.6    Kopan, R.7
  • 44
    • 0033962585 scopus 로고    scopus 로고
    • A genetic screen for novel components of the Ras/mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
    • Rebay I, Chen F, Hsiao F, Kolodziej PA, Kuang BH, Laverty T, Suh C, Voas M, Williams A, Rubin GM (2000). A genetic screen for novel components of the Ras/mitogen-activated protein kinase signaling pathway that interacts with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154, 695-712. (Pubitemid 30096592)
    • (2000) Genetics , vol.154 , Issue.2 , pp. 695-712
    • Rebay, I.1    Chen, F.2    Hsiao, F.3    Kolodziej, P.A.4    Kuang, B.H.5    Laverty, T.6    Suh, C.7    Voas, M.8    Williams, A.9    Rubin, G.M.10
  • 45
    • 0029939271 scopus 로고    scopus 로고
    • Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster
    • DOI 10.1002/(SICI)1520-6408(1996)18:1<28::AID-DVG4>3.0.CO;2-3
    • Schweisguth F, Gho M, Lecourtois M (1996). Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster. Dev Genet 18, 28-39. (Pubitemid 26076000)
    • (1996) Developmental Genetics , vol.18 , Issue.1 , pp. 28-39
    • Schweisguth, F.1    Gho, M.2    Lecourtois, M.3
  • 46
    • 0031983193 scopus 로고    scopus 로고
    • LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein
    • Taniguchi Y, Furukawa T, Tun T, Han H, Honjo T (1998). LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol Cell Biol 18, 644-654. (Pubitemid 28021074)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.1 , pp. 644-654
    • Taniguchi, Y.1    Furukawa, T.2    Tun, T.3    Han, H.4    Honjo, T.5
  • 47
    • 0037031590 scopus 로고    scopus 로고
    • An EGFR/Ebi/Sno pathway promotes Delta expression by inactivating Su(H)/SMRTER repression during inductive Notch signaling
    • DOI 10.1016/S0092-8674(02)00875-9
    • Tsuda L, Nagaraj R, Zipurski SL, Banerjee U (2002). An EGFR/Ebi/Sno pathway promotes Delta expression by inactivating Su(H)/SMRTER repression during inductive Notch signalling. Cell 110, 625-637. (Pubitemid 35247842)
    • (2002) Cell , vol.110 , Issue.5 , pp. 625-637
    • Tsuda, L.1    Nagaraj, R.2    Zipursky, S.L.3    Banerjee, U.4
  • 48
    • 79955429963 scopus 로고    scopus 로고
    • Transcriptional repression in the Notch pathway:Thermodynamic characterization of CSL-MINT complexes
    • VanderWielen BD, Yuan Z, Friedmann DR, Kovall RA (2011). Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT complexes. J Biol Chem 286, 14892-14902.
    • (2011) J Biol Chem , vol.286 , pp. 14892-14902
    • VanderWielen, B.D.1    Yuan, Z.2    Friedmann, D.R.3    Kovall, R.A.4
  • 49
    • 33644761961 scopus 로고    scopus 로고
    • Crystal structure of the CSL-Notch-Mastermind Ternary complex bound to DNA
    • DOI 10.1016/j.cell.2006.01.035, PII S009286740600170X
    • Wilson JJ, Kovall RA (2006). Crystal structure of the CSL-Notch-mastermind ternary complex bound to DNA. Cell 124, 985-996. (Pubitemid 43344238)
    • (2006) Cell , vol.124 , Issue.5 , pp. 985-996
    • Wilson, J.J.1    Kovall, R.A.2
  • 50
    • 0033920386 scopus 로고    scopus 로고
    • A role for SKIP in EBNA2 activation of CBF1-repressed promoters
    • DOI 10.1128/JVI.74.4.1939-1947.2000
    • Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (2000). A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol 74, 1939-1947. (Pubitemid 30434053)
    • (2000) Journal of Virology , vol.74 , Issue.4 , pp. 1939-1947
    • Zhou, S.1    Fujimuro, M.2    Hsieh, J.J.-D.3    Chen, L.4    Hayward, S.D.5
  • 51
    • 0142210110 scopus 로고    scopus 로고
    • Structure and stability of the ankyrin domain of the Drosophila Notch receptor
    • DOI 10.1110/ps.03279003
    • Zweifel ME, Leahy DJ, Hughson FM, Barrick D (2003). Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Sci 12, 2622-2632. (Pubitemid 37310801)
    • (2003) Protein Science , vol.12 , Issue.11 , pp. 2622-2632
    • Zweifel, M.E.1    Leahy, D.J.2    Hughson, F.M.3    Barrick, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.