Subcellular localization of Hairless protein shows a major focus of activity within the nucleus

Mechanisms of Development

Volumn 89, Issue 1-2, 1999, Pages 195-199

  Maier, Dieter ^a   Nagel, Anja C ^a   Johannes, Bernd ^a   Preiss, Anette ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Antagonist; Clone; Cytosolic; Distribution; Drosophila; Ectopic; Expression; FLP; Fly; FRT; Gain; Gal4; Germ line; Hairless; Localization; Loss; Masking; Mis expression; Mosaic; Mutant; Notch; Nuclear; Pathway; Protein; Retention; Signal; Subce llular; Suppressor of Hairless; Transcription; Transduction

Indexed keywords

PROTEIN;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; DROSOPHILA; EMBRYO; GENE; GENE ACTIVATION; GENETIC TRANSCRIPTION; IMMUNOCYTOCHEMISTRY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL NUCLEUS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNE SERA; INSECT PROTEINS; MUTATION; OVARY; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; WING;

EID: 0032745064     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(99)00208-7     Document Type: Article

References (20)

1. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science. 268:1999;225-232.
2. Bang A.G., Posakony J.W. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 6:1992;1752-1769.
3. Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118:1993;401-415.
4. Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilasky P., Schweisguth F., Israel A. Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homologue KBF2/RBP-Jk, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8:1994;2491-2503.
5. Capdevila J., Guerrero I. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alteration in Drosophila wings. EMBO J. 13:1994;4459-4468.
6. de Celis J.F., de Celis J., Ligoxygakis P., Preiss A., Delidakis C., Bray S. Functional relationship between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development. 122:1996;2719-2728.
7. Dou S., Zeng X., Cortes P., Erdjument-Bromage H., Tempst P., Honjo T., Vales L.D. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol. Cell. Biol. 14:1994;3310-3319.
8. Fehon R.G., Kooh P.J., Rebay I., Regan C.L., Xu T., Muskavitch M.A.T., Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 61:1990;523-534.
9. Gho M., Lecourtois M., Géraud G., Posakony J.W., Schweisguth F. Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development. 122:1996;1673-1682.
10. Hinz U., Giebel B., Campos-Ortega J.A. The basic helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell. 76:1994;77-87.
11. Jarriault S., Brou C., Logeat F., Schroeter H., Kopan R., Israel A. Signaling downstream of activated mammalian Notch. Nature. 377:1995;355-358.
12. Johansen K.M., Fehon R.G., Artavanis-Tsakonas S. The Notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development, J. Cell Biol. 109:1989;2427-2440.
13. Lecourtois M., Schweisguth F. The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9:1995;2598-2608.
14. Maier D., Stumm G., Kuhn K., Preiss A. Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein. Mech. Dev. 38:1992;143-156.
15. Maier D., Marquart J., Thompson-Fontaine A., Beck I., Wurmbach E., Preiss A. In vivo structure-function analysis of Drosophila Hairless. Mech. Dev. 67:1997;97-106.
16. Marquart J., Alexief-Damianof C., Preiss A., Maier D. Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless. Dev. Genes Evol. 209:1999;155-164.
17. Micchelli C.A., Rulifson E.J., Blair S.S. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development. 124:1997;1485-1495.
18. Neumann C.J., Cohen S.M. A hierarchy of cross-regulation involving Notch, wingless and cut organizes the dorsal/ventral axis of the Drosophila wing. Development. 122:1996;3477-3485.
19. Verheyen E., Cooley L. Drosophila melanogaster: Practical Uses in Cell and Molecular Biology. Vol. 44. 1994;Academic Press, San Diego, CA.
20. Xu T., Rubin G.M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development. 117:1993;1223-1237.