A genetic screen for novel components of the Ras/mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein

Genetics

Volumn 154, Issue 2, 2000, Pages 695-712

  Rebay, Ilaria ^a,b   Chen, Fangli ^a   Hsiao, Francis ^a   Kolodziej, Peter A ^c   Kuang, Bing H ^c   Laverty, Todd ^b   Suh, Chris ^b   Voas, Matthew ^a   Williams, Andrina ^a   Rubin, Gerald M ^b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN; RNA BINDING PROTEIN;

ARTICLE; DNA FLANKING REGION; DROSOPHILA; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC SCREENING; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA; DROSOPHILA; DROSOPHILA PROTEINS; EYE; EYE PROTEINS; HOMEODOMAIN PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ARACHNIDA; HEXAPODA;

EID: 0033962585     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. AMREIN, H., M. L. HEDLEY and T. MANIATIS, 1994 The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell 76: 735-746.
2. BELL, L. R., E. M. MAINE, P. SCHEDL and T. W. CLINE, 1988 Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins. Cell 55: 1037-1046.
3. BERGER, B., D. B. WILSON, E. WOLF, T. TONCHEV, M. MILLA et al., 1995 Predicting coiled coils by use of pairwise residue correlations. Proc. Natl. Acad. Sci. USA 92: 8259-8263.
4. BERGMANN, A., J. AGAPITE, K. MCCALL and H. STELLER, 1998 The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95: 331-341.
5. BIGGS, W. H. R., K. H. ZAVITZ, B. DICKSON, A. VAN DER STRATEN, D. BRUNNER et al., 1994 The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J. 13: 1628-1635.
6. BONINI, N. M., W. M. LEISERSON and S. BENZER, 1993 The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell 72: 379-395.
7. BONINI, N. M., Q. T. BUI, G. L. GRAY-BOARD and J. M. WARRICK, 1997 The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development 124: 4819-4826.
8. BONINI, N. M., W. M. LEISERSON and S. BENZER, 1998 Multiple roles of the eyes absent gene in Drosophila. Dev. Biol. 196: 42-57.
9. BRUNNER, D., K. DUCKER, N. OELLERS, E. HAFEN, H. SCHOLZ et al., 1994 The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-389.
10. BUFF, E., A. CARMENA, S. GISSELBRECHT, F. JIMENEZ and A. M. MICHELSON, 1998 Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125: 2075-2086.
11. BURD, C. G., and G. DREYFUSS, 1994 Conserved structures and diversity of functions of RNA-binding proteins. Science 265: 615-621.
12. CAGAN, R. L., and D. F. READY, 1989 Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3: 1099-1112.
13. CHARDIN, P., J. H. CAMONIS, N. W. GALE, L. VAN AELST, J. SCHLESSINGER et al., 1993 Human SosI:a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260: 1338-1343.
14. CHEN, R., M. AMOUI, Z. ZHANG and G. MARDON, 1997 Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell 91: 893-903.
15. DE CELIS, J. F., and S. BRAY, 1997 Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124: 3241-3251.
16. DICKSON, B., and E. HAFEN, 1994 Genetics of signal transduction in invertebrates. Curr. Opin. Genet. Dev. 4: 64-70.
17. DICKSON, B. J., A. VAN DER STRATEN, M. DOMINGUEZ and E. HAFEN, 1996 Mutations modulating Raf signaling in Drosophila eye development. Genetics 142: 163-171.
18. DUFFY, J. B., and N. PERRIMON, 1994 The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. Dev. Biol. 166: 380-395.
19. DUFFY, J. B., D. A. HARRISON and N. PERRIMON, 1998 Identifying loci required for follicular patterning using directed mosaics. Development 125: 2263-2271.
20. EDGAR, B. A., and P. H. O'FARRELL, 1989 Genetic control of cell division patterns in the Drosophila embryo. Cell 57: 177-187.
21. EDGAR, B. A., and P. H. O'FARRELL, 1990 The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell 62: 469-480.
22. ELLIS, M. C., E. M. O'NEILL and G. M. RUBIN, 1993 Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development 119: 855-865.
23. ENGSTROM, L., E. NOLL and N. PERRIMON, 1997 Paradigms to study signal transduction pathways in Drosophila. Curr. Top. Dev. Biol. 35: 229-261.
24. FORTINI, M. E., M. A. SIMON and G. M. RUBIN, 1992 Signalling In the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355: 559-561.
25. FORTINI, M. E., I. REBAY, L. A. CARON and S. ARTAVANIS-TSAKONAS, 1993 An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365: 555-557.
26. GREENWALD, I., 1998 LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12: 1751-1762.
27. GREGORY, S. L., R. D. KORTSCHAK, B. KALIONIS and R. SAINT, 1996 Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Mol. Cell. Biol. 16: 792-799.
28. HALDER, G., P. CALLAERTS, S. FLISTER, U. WALLDORF, U. KLOTER et al., 1998 Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125: 2181-2191.
29. HAY, B. A., T. WOLFF and G. M. RUBIN, 1994 Expression of baculovirus P35 prevents cell death in Drosophila. Development 120: 2121-2129.
30. HEBERLEIN, U., T. WOLFF and G. M. RUBIN, 1993 The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell 75: 913-926.
31. HOEY, T., R. O. WEINZIERL, G. GILL, J. L., CHEN, B. D. DYNLACHI et al., 1993 Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell 72: 247-260.
32. KARIM, F. D., H. C. CHANG, M. THERRIEN, D. A. WASSARMAN, T. LAVERTY et al., 1996 A screen for genes that function down-stream of Ras1 during Drosophila eye development. Genetics 143: 315-329.
33. KLAMBT, C., 1993 The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117: 163-176.
34. KOCKEL, L., J. ZEITLINGER, L. M. STASZEWSKI, M. MLODZIK and D. BOHMANN, 1997 Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 11: 1748-1758.
35. KOLODKIN, A. L., A. T. PICKUP, D. M. LIN, C. S. GOODMAN and U. BANERJEE, 1994 Chracterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila. Development 120: 1731-1745.
36. KOLODZIEJ, P. A., L. Y. JAN and Y. N. JAN, 1995 Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo. Neuron 15: 273-286.
37. KOUSHIKA, S. P., M. J. LISBIN and K. WHITE, 1996 ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform. Curr. Biol. 6: 1634-1641.
38. LAI, Z. C., and G. M. RUBIN, 1992 Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70: 609-620.
39. LEE, T., and D. J. MONTELL, 1997 Multiple Ras signals pattern the Drosophila ovarian follicle cells. Dev. Biol. 185: 25-33.
40. LEISERSON, W. M., B. SEYMOUR and N. M. BONINI, 1998 Dual functions of the Drosophila eyes absent gene in the eye and embryo. Mech. Dev. 73: 193-202.
41. MARSHALL, C. J., 1994 MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4: 82-89.
42. MARUTA, H., and A. W. BURGESS, 1994 Regulation of the Ras signalling network. Bioessays 16: 489-496.
43. MATUNIS, E. L., R. KELLEY and G. DREYFUSS, 1994 Essential role for a heterogeneous nuclear ribonucleoprotein (hnRNP) in oogenesis: hrp40 is absent from the germ line in the dorsoventral mutant squid. Proc. Natl. Acad. Sci. USA 91: 2781-2784.
44. MILLER, D. T., and R. L. CAGAN, 1998 Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125: 2327-2335.
45. NEUFELD, T. P., A. H. TANG and G. M. RUBIN, 1998 A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. Genetics 148: 277-286.
46. NIMNUAL, A. S., B. A. YATSULA and D. BAR-SAGI, 1998 Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279: 560-563.
47. NOSELLI, S., 1998 JNK signaling and morphogenesis in Drosophila. Trends Genet. 14: 33-38.
48. NUSSLEIN-VOLHARD, C., E. WIESCHAUS and H. KULDING, 1984 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. Roux's Arch Dev. Biol. 193: 267-282.
49. O'NEILL, E. M., I. REBAY, R. TJIAN and G. M. RUBIN, 1994 The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147.
50. PICKUP, A. T., and U. BANERJEE, 1999 The role of Star in the production of an activated ligand for the EGF receptor signaling pathway. Dev. Biol. 205: 254-259.
51. PIGNONI, F., and S. L. ZIPURSKY, 1997 Induction of Drosophila eye development by decapentaplegic. Development 124: 271-278.
52. PIGNONI, F., B. HU, K. H. ZAVITZ, J. XIAO, P. A. GARRITY et al., 1997 The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91: 881-891.
53. PIRROTTA, V., 1986 Cloning Drosophila genes, pp. 83-110 in Drosophila: A Practical Approach, edited by D. R. ROBERTS. Oxford University Press, Washington, DC.
54. PRICE, J. V., E. D. SAVENYE, D. LUM and A. BRETTKREUTZ, 1997 Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics 147: 1139-1153.
55. REBAY, I., and G. M. RUBIN, 1995 Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81: 857-866.
56. RIESGO-ESCOVAR, J. R., and E. HAFEN, 1997 Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-I transcription factor DJun during dorsal closure. Genes Dev. 11: 1717-1727.
57. ROGGE, R., P. J. GREEN, J. URANO, S. HORN-SABAN, M. MLODZIK et al., 1995 The role of yan in mediating the choice between cell division and differentiation. Development 121: 3947-3958.
58. ROGGE, R. D., C. A. KARLOVICH and U. BANERJEE, 1991 Genetic dissection of a neurodevelopmental pathway: son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64: 39-48.
59. RUBIN, G. M., 1988 Drosophila melanogaster as an experimental organism. Science 240: 1453-1459.
60. SAMAKOVLIS, C., N. HACOHEN, G. MANNING, D. C. SUTHERLAND, K. GUILLEMIN et al., 1996 Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122: 1395-1407.
61. SCHNORR, J. D., and C. A. BERG, 1996 Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. Genetics 144: 1545-1557.
62. SCHOLZ, H., E. SADLOWSKI, A. KLAES and C. KLAMBT, 1997 Control of midline glia development in the embryonic Drosophila CNS. Mech. Dev. 62: 79-91.
63. SCHWEITZER, R., and B. Z. SHILO, 1997 A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13: 191-196.
64. SHILO, B. Z., 1992 Roles of receptor tyrosine kinases in Drosophila development. FASEB J. 6: 2915-2922.
65. SIMON, M. A., D. D. BOWTELL, G. S. DODSON, T. R. LAVERTY and G. M. RUBIN, 1991 Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67: 701-716.
66. SOTSSON, S. M., A. S. NIMNUAL, M. UY, D. BAR-SAGI and J. KURIYAN, 1998 Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell 95:259-268.
67. THOMAS, B. J., D. A. GUNNING, J. CHO and L. ZIPURSKY, 1994 Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1. Cell 77: 1003-1014.
68. TOMLINSON, A., and D. READY, 1986 Neuronal differentiation in the Drosophila ommatidium. Dev. Biol. 120: 366-376.
69. TOMLINSON, A., D. D. BOWTELL, E. HAFEN and G. M. RUBIN, 1987 Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell 51: 143-150.
70. TREISMAN, J. F., and G. M. RUBIN, 1995 wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121: 3519-3527.
71. VAN DER GEER, P., T. HUNTER and R. A. LINDBERG, 1994 Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10: 251-337.
72. VERHEYEN, E. M., K. J. PURCELL, M. E. FORTINI and S. ARTAVANIS-TSAKONAS, 1996 Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics 144: 1127-1141.
73. WANG, H., I. CLARK, P. R. NICHOLSON, I. HERSKOWITZ and D. J. STILLMAN, 1990 The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol. Cell. Biol. 10: 5927-5936.
74. WOLF, E., P. S. KIM and B. BERGER, 1997 MultiCoil: a program for predicting two- and three-stranded coiled coils. Protein Sci. 6: 1179-1189.
75. YANNONI, Y. M., and K. WHITE, 1997 Association of the neuron-specific RNA binding domain-containing protein ELAV with the coiled body in Drosophila neurons. Chromosoma 105: 332-341.
76. ZIPURSKY, S. L., and G. M. RUBIN, 1994 Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17: 373-397.