High-affinity DNA targeting using readily accessible mimics of N2′-functionalized 2′-amino-α-L-LNA

Journal of Organic Chemistry

Volumn 76, Issue 17, 2011, Pages 7119-7131

  Karmakar, Saswata ^a   Anderson, Brooke A ^a   Rathje, Rie L ^a,b   Andersen, Sanne ^a,b   Jensen, Troels B ^b   Nielsen, Poul ^b   Hrdlicka, Patrick J ^a  

^a UNIVERSITY OF IDAHO   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; DNA TARGETS; FUNCTIONAL MIMICS; FUNCTIONALIZED; INTERCALATORS; LOCKED NUCLEIC ACID; MATERIAL SCIENCE; PREORGANIZATION; SURFACE AREA; SYNTHETIC ROUTES; THERMAL DENATURATIONS; UV-VIS ABSORPTIONS;

ABSORPTION SPECTROSCOPY; FLUORESCENCE SPECTROSCOPY; MONOMERS; PYROLYSIS;

DNA;

2' N (PYREN 1 YLMETHYL) 2' N METHYLAMINOURIDINE; 2' O (CORONEN 1 YL)METHYLURIDINE; 2' O (PYREN 1 YL)METHYLURIDINE; COMPLEMENTARY DNA; CORONENE; INTERCALATING AGENT; LOCKED NUCLEIC ACID; MONOMER; N2' PYRENE FUNCTIONALIZED 2' AMINO ALPHA LOCKED NUCLEIC ACID; N2' PYRENE FUNCTIONALIZED 2' N METHYL 2' AMINODEOXYURIDINE PHOSPHORAMIDITE; O2' INTERCALATOR FUNCTIONALIZED URIDINE; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; PYRENE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DENATURATION; DNA HYBRIDIZATION; FLUORESCENCE SPECTROSCOPY; GENE TARGETING; LIGHT ABSORPTION; STEREOCHEMISTRY; SURFACE PROPERTY; SYNTHESIS;

BIOMIMETICS; DNA; DRUG DELIVERY SYSTEMS; INTERCALATING AGENTS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES;

EID: 80052178337     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201095p     Document Type: Article

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