N2′-functionalized 2′-amino-α-L-LNA adenine derivatives - Efficient targeting of single stranded DNA

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 10-12, 2007, Pages 1415-1417

  Andersen, Nicolai K ^a   Wengel, Jesper ^a   Hrdlicka, Patrick J ^a,b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF IDAHO   (United States)

Author keywords

Antigene; Antisense; Conformationally restricted nucleosides

Indexed keywords

ADENINE DERIVATIVE; AMINO ACID DERIVATIVE; COMPLEMENTARY DNA; LOCKED NUCLEIC ACID; SINGLE STRANDED DNA; 2' N (PYREN 1 YL)ACETYL 2' AMINO ALPHA L LNA; 2'-N-(PYREN-1-YL)ACETYL-2'-AMINO-ALPHA-L-LNA; ADENINE; DRUG DERIVATIVE; OLIGODEOXYRIBONUCLEOTIDE; OLIGONUCLEOTIDE; PYRIDINE DERIVATIVE; RNA; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DENATURATION; DERIVATIZATION; DNA STRAND; NUCLEIC ACID SYNTHESIS; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THERMODYNAMICS; CHEMISTRY; DNA DENATURATION;

ADENINE; DNA, SINGLE-STRANDED; NUCLEIC ACID DENATURATION; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES; PYRIDINES; RNA; THYMIDINE MONOPHOSPHATE;

EID: 36949019562     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701539153     Document Type: Article

References (6)

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3. Hrdlicka, P.J.; Babu, B.R.; Sørensen, M.D.; Harrit, N.; Wengel, J. Multilabeled pyrene-functionalized 2′-amino-LNA probes for nucleic acid detection in homogenous fluorescence assays. J. Am. Chem. Soc. 2005, 127, 13293-13299 and references cited herein.
4. Hrdlicka, P.J.; Kumar, T.S.; Wengel, J. Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-L-LNA. Chem. Comm. 4279-4281.
5. Kumar, T.S.; Madsen, A.S.; Wengel, J.; Hrdlicka, P.J. Synthesis and hybridization studies of 2′-amino-α-L-LNA and a tetracyclic 'locked LNA.' J. Org. Chem. 2006, 71, 4188-4201.
6. Sørensen, M.D.; Wengel, J.; Koch, T., Christensen, S.M.; Rosenbohm, C.; Pedersen, D.S. Synthesis of locked nucleic acid derivatives. Patent application WO03095467.