Interaction of FTO and physical activity level on adiposity in african-american and European-American adults: The ARIC study

Obesity

Volumn 19, Issue 9, 2011, Pages 1866-1872

  Demerath, Ellen W ^a   Lutsey, Pam L ^a   Monda, Keri L ^b   Linda Kao, Wen Hong ^c   Bressler, Jan ^d   Pankow, James S ^a   North, Kari E ^b,e   Folsom, Aaron R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b IL   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFRICAN AMERICAN; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CAUCASIAN; CIGARETTE SMOKING; CONTROLLED STUDY; EDUCATIONAL STATUS; ETHNICITY; EUROPEAN AMERICAN; FEMALE; FTO GENE; GENE; GENE DOSAGE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; OBESITY; PHYSICAL ACTIVITY; QUESTIONNAIRE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SKINFOLD THICKNESS; SPORT; WAIST CIRCUMFERENCE;

ADIPOSITY; AFRICAN AMERICANS; AGED; COHORT STUDIES; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; INTRONS; MALE; MIDDLE AGED; MOTOR ACTIVITY; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; PROTEINS; SEX CHARACTERISTICS; SPORTS; UNITED STATES; WAIST CIRCUMFERENCE;

EID: 80052160447     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.131     Document Type: Article

References (43)

1. Plomin R, DeFries JC, Loehlin JC. Genotype-environment interaction and correlation in the analysis of human behavior. Psychol Bull 1977;84: 309-322.
2. Pérusse L, Bouchard C. Genotype-environment interaction in human obesity. Nutr Rev 1999;57:S31-7; discussion S37.
3. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894. (Pubitemid 46764279)
4. Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
5. Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726. (Pubitemid 46848595)
6. Vimaleswaran KS, Li S, Zhao JH et al. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr 2009;90:425-428.
7. Cornes BK, Lind PA, Medland SE et al. Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. Int J Obes (Lond) 2009;33:75-79.
8. Andreasen CH, Stender-Petersen KL, Mogensen MS et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008;57:95-101.
9. Rampersaud E, Mitchell BD, Pollin TI et al. Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 2008;168:1791-1797.
10. Ruiz JR, Labayen I, Ortega FB et al.; HELENA Study Group. Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. Arch Pediatr Adolesc Med 2010;164:328-333.
11. Hetherington MM, Cecil JE. Gene-environment interactions in obesity. Forum Nutr 2010;63:195-203.
12. Rankinen T, Roth SM, Bray MS et al. Advances in exercise, fitness, and performance genomics. Med Sci Sports Exerc 2010;42:835-846.
13. Kang SJ, Chiang CW, Palmer CD et al. Genome-wide association of anthropometric traits in African-and African-derived populations. Hum Mol Genet 2010;19:2725-2738.
14. Bressler J, Kao WH, Pankow JS, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS ONE 2010;5:e10521.
15. ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol 1989;129:687-702.
16. Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Abridged edn. Human Kinetics Books, Champaign, IL, 1991.
17. ARIC Investigators. ARIC Study Website. 〈http://www.cscc.unc.edu/ aric/〉 (2008).
18. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982;36:936-942. (Pubitemid 13214364)
19. Meyer AM, Evenson KR, Couper DJ et al. Television, physical activity, diet, and body weight status: the ARIC cohort. Int J Behav Nutr Phys Act 2008;5:68.
20. Cohen J. A Coefficient of agreement for nominal scales. Educ Psychol Meas 1960;20:37-46.
21. The American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-1197.
22. Patterson N, Hattangadi N, Lane B et al. Methods for high-density admixture mapping of disease genes. Am J Hum Genet 2004;74:979-1000. (Pubitemid 38578397)
23. The International HapMap Consortium. The International HapMap Project. Nature 2003;426:789-796.
24. Fujimoto WY, Jablonski KA, Bray GA et al.; Diabetes Prevention Program Research Group. Body size and shape changes and the risk of diabetes in the diabetes prevention program. Diabetes 2007;56:1680-1685. (Pubitemid 46842603)
25. Song Y, You NC, Hsu YH et al. FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women. Obesity (Silver Spring) 2008;16:2472-2480.
26. Gerken T, Girard CA, Tung YC et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472. (Pubitemid 350208961)
27. Willer CJ, Speliotes EK, Loos RJ et al.; Wellcome Trust Case Control Consortium; Genetic Investigation of ANthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
28. Fischer J, Koch L, Emmerling C et al. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898.
29. Fredriksson R, Hägglund M, Olszewski PK et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008;149:2062-2071. (Pubitemid 351574484)
30. Church C, Lee S, Bagg EA et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009;5:e1000599.
31. Wardle J, Carnell S, Haworth CM et al. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008;93:3640-3643.
32. Bollepalli S, Dolan LM, Deka R, Martin LJ. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring) 2010;18:1959-1963.
33. Liu G, Zhu H, Lagou V et al. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European-and African-American youth. BMC Med Genet 2010;11:57.
34. Adeyemo A, Chen G, Zhou J et al. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes 2010;59:1549-1554.
35. Grant SF, Li M, Bradfield JP et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS ONE 2008;3:e1746.
36. Hennig BJ, Fulford AJ, Sirugo G et al. FTO gene variation and measures of body mass in an African population. BMC Med Genet 2009;10:21.
37. Wing MR, Ziegler J, Langefeld CD et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet 2009;125:615-626.
38. Karasawa S, Daimon M, Sasaki S et al. Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr J 2010;57:293-301.
39. Harris JR, Tambs K, Magnus P. Sex-specific effects for body mass index in the new Norwegian twin panel. Genet Epidemiol 1995;12:251-265.
40. Pietiläinen KH, Kaprio J, Rissanen A et al. Distribution and heritability of BMI in Finnish adolescents aged 16y and 17y: a study of 4884 twins and 2509 singletons. Int J Obes Relat Metab Disord 1999;23:107-115. (Pubitemid 29057503)
41. Rankinen T, Rice T, Teran-Garcia M, Rao DC, Bouchard C. FTO genotype is associated with exercise training-induced changes in body composition. Obesity (Silver Spring) 2010;18:322-326.
42. Jacobsson JA, Danielsson P, Svensson V et al. Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 2008;368:476-482.
43. Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet 2010;26:266-274.