Multiple new site-specific recombinases for use in manipulating animal genomes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14198-14203

  Nern, Aljoscha ^a   Pfeiffer, Barret D ^a   Svoboda, Karel ^a   Rubin, Gerald M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Gene expression; Genetic engineering

Indexed keywords

CRE RECOMBINASE; HEAT SHOCK PROTEIN 70; RECOMBINASE; TRANSCRIPTION FACTOR GAL4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL GENETICS; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENETIC MANIPULATION; GENOME; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN VIRUS 40; YEAST;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA NUCLEOTIDYLTRANSFERASES; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENOME; INTEGRASES; MICE; MICE, INBRED C57BL; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE;

ANIMALIA; MUS;

EID: 80052157467     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111704108     Document Type: Article

References (58)

1. García-Otín AL, Guillou F (2006) Mammalian genome targeting using site-specific recombinases. Front Biosci 11:1108-1136.
2. Dymecki SM, Kim JC (2007) Molecular neuroanatomy's "Three Gs": A primer. Neuron 54:17-34.
3. Luan H, White BH (2007) Combinatorial methods for refined neuronal gene targeting. Curr Opin Neurobiol 17:572-580.
4. Birling MC, Gofflot F, Warot X (2009) Site-specific recombinases for manipulation of the mouse genome. Methods Mol Biol 561:245-263.
5. Grindley ND, Whiteson KL, Rice PA (2006) Mechanisms of site-specific recombination. Annu Rev Biochem 75:567-605. (Pubitemid 44118044)
6. Hartley JL, Donelson JE (1980) Nucleotide sequence of the yeast plasmid. Nature 286:860-865.
7. Golic KG, Lindquist S (1989) The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59:499-509. (Pubitemid 19284463)
8. Struhl G, Basler K (1993) Organizing activity of wingless protein in Drosophila. Cell 72:527-540. (Pubitemid 23077741)
9. Golic KG (1991) Site-specific recombination between homologous chromosomes in Drosophila. Science 252:958-961.
10. Xu T, Rubin GM(1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223-1237. (Pubitemid 23154489)
11. Lee T, Luo L (1999) Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22:451-461. (Pubitemid 29159845)
12. Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM (2003) Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35:70-75. (Pubitemid 37048598)
13. Farago AF, Awatramani RB, Dymecki SM (2006) Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50:205-218.
14. Voziyanov Y, Konieczka JH, Stewart AF, Jayaram M (2003) Stepwise manipulation of DNA specificity in Flp recombinase: Progressively adapting Flp to individual and combinatorial mutations in its target site. J Mol Biol 326:65-76. (Pubitemid 36279359)
15. Hadjieconomou D, et al. (2011) Flybow: Genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster. Nat Methods 8:260-266.
16. Nagy A (2000) Cre recombinase: The universal reagent for genome tailoring. Genesis 26:99-109.
17. Sauer B, Henderson N (1988) Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85:5166-5170.
18. Orban PC, Chui D, Marth JD (1992) Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89:6861-6865.
19. Siegal ML, Hartl DL (1996) Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 144:715-726. (Pubitemid 26325862)
20. Heidmann D, Lehner CF (2001) Reduction of Cre recombinase toxicity in proliferating Drosophila cells by estrogen-dependent activity regulation. Dev Genes Evol 211:458-465. (Pubitemid 32927045)
21. Schmidt EE, Taylor DS, Prigge JR, Barnett S, Capecchi MR (2000) Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci USA 97:13702-13707.
22. Forni PE, et al. (2006) High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 26:9593-9602. (Pubitemid 44396872)
23. Schmidt-Supprian M, Rajewsky K (2007) Vagaries of conditional gene targeting. Nat Immunol 8:665-668. (Pubitemid 46965339)
24. Coppoolse ER, et al. (2003) Cre recombinase expression can result in phenotypic aberrations in plants. Plant Mol Biol 51:263-279. (Pubitemid 36189190)
25. Sauer B, McDermott J (2004) DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages. Nucleic Acids Res 32:6086-6095. (Pubitemid 40074003)
26. Anastassiadis K, et al. (2009) Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice. Dis Model Mech 2:508-515.
27. Groth AC, Olivares EC, Thyagarajan B, Calos MP (2000) A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci USA 97:5995-6000. (Pubitemid 30367512)
28. Groth AC, Fish M, Nusse R, Calos MP (2004) Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics 166:1775-1782. (Pubitemid 38621059)
29. Bateman JR, Lee AM, Wu CT (2006) Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics 173:769-777. (Pubitemid 43945895)
30. Turan S, et al. (2011) Recombinase-mediated cassette exchange (RMCE): Traditional concepts and current challenges. J Mol Biol 407:193-221.
31. Araki H, et al. (1985) Molecular and functional organization of yeast plasmid pSR1. J Mol Biol 182:191-203.
32. Yang SH, Jayaram M (1994) Generality of the shared active site among yeast family site-specific recombinases. The R site-specific recombinase follows the Flp paradigm [corrected]. J Biol Chem 269:12789-12796. (Pubitemid 24202074)
33. Onouchi H, et al. (1991) Operation of an efficient site-specific recombination system of Zygosaccharomyces rouxii in tobacco cells. Nucleic Acids Res 19:6373-6378. (Pubitemid 21913062)
34. Volkert FC, Wilson DW, Broach JR (1989) Deoxyribonucleic acid plasmids in yeasts. Microbiol Rev 53:299-317. (Pubitemid 19221276)
35. Chen XJ, Saliola M, Falcone C, Bianchi MM, Fukuhara H (1986) Sequence organization of the circular plasmid pKD1 from the yeast Kluyveromyces drosophilarum. Nucleic Acids Res 14:4471-4481.
36. Toh-e A, Araki H, Utatsu I, Oshima Y (1984) Plasmids resembling 2-micrometers DNA in the osmotolerant yeasts Saccharomyces bailii and Saccharomyces bisporus. J Gen Microbiol 130:2527-2534. (Pubitemid 14016441)
37. Utatsu I, Sakamoto S, Imura T, Toh-e A (1987) Yeast plasmids resembling 2 micron DNA: Regional similarities and diversities at the molecular level. J Bacteriol 169:5537-5545.
38. Utatsu I, Utsunomiya A, Toh-e A (1986) Functions encoded by the yeast plasmid pSB3 isolated from Zygosaccharomyces rouxii IFO 1730 (formerly Saccharomyces bisporus var. mellis). J Gen Microbiol 132:1359-1365. (Pubitemid 16115644)
39. Araki H, et al. (1992) Site-specific recombinase, R, encoded by yeast plasmid pSR1. J Mol Biol 225:25-37.
40. Toh-e A, Utatsu I (1985) Physical and functional structure of a yeast plasmid, pSB3, isolated from Zygosaccharomyces bisporus. Nucleic Acids Res 13:4267-4283.
41. Loetscher P, Pratt G, Rechsteiner M (1991) The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis. J Biol Chem 266:11213-11220. (Pubitemid 21906934)
42. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415. (Pubitemid 23214028)
43. Pfeiffer BD, et al. (2010) Refinement of tools for targeted gene expression in Drosophila. Genetics 186:735-755.
44. Shaner NC, et al. (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 22:1567-1572. (Pubitemid 40039460)
45. Pfeiffer BD, et al. (2008) Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci USA 105:9715-9720. (Pubitemid 352031366)
46. Blaisonneau J, Sor F, Cheret G, Yarrow D, Fukuhara H (1997) A circular plasmid from the yeast Torulaspora delbrueckii. Plasmid 38:202-209. (Pubitemid 28027448)
47. Suzuki E, Nakayama M (2011) VCre/VloxP and SCre/SloxP: New site-specific recombination systems for genome engineering. Nucleic Acids Res 39:e49.
48. Babineau D, et al. (1985) The FLP protein of the 2-micron plasmid of yeast. Purification of the protein from Escherichia coli cells expressing the cloned FLP gene. J Biol Chem 260:12313-12319. (Pubitemid 16228407)
49. Freeman M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87:651-660.
50. Saito T, Nakatsuji N (2001) Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol 240:237-246. (Pubitemid 33141120)
51. Petreanu L, Huber D, Sobczyk A, Svoboda K (2007) Channelrhodopsin-2- assisted circuit mapping of long-range callosal projections. Nat Neurosci 10:663-668. (Pubitemid 46652447)
52. Kügler S, et al. (2001) Neuron-specific expression of therapeutic proteins: Evaluation of different cellular promoters in recombinant adenoviral vectors. Mol Cell Neurosci 17:78-96. (Pubitemid 32113540)
53. Südhof TC (1990) The structure of the human synapsin I gene and protein. J Biol Chem 265:7849-7852.
54. Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199.
55. Gray NW, Weimer RM, Bureau I, Svoboda K (2006) Rapid redistribution of synaptic PSD-95 in the neocortex in vivo. PLoS Biol 4:e370.
56. Petreanu L, Mao T, Sternson SM, Svoboda K (2009) The subcellular organization of neocortical excitatory connections. Nature 457:1142-1145.
57. Buchholz F, Angrand PO, Stewart AF (1998) Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol 16:657-662. (Pubitemid 28334324)
58. Rodríguez CI, et al. (2000) High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25:139-140. (Pubitemid 30394979)