Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14103-14108

  Kang, Ho Chul ^a,b   Lee, Yun Il ^a,b   Shin, Joo Ho ^a,b   Andrabi, Shaida A ^a,b   Chi, Zhikai ^a,b   Gagné, Jean Philippe ^c   Lee, Yunjong ^a,b   Ko, Han Seok ^a,b   Lee, Byoung Dae ^a,b   Poirier, Guy G ^c   Dawson, Valina L ^a,b   Dawson, Ted M ^a,b  

^a Institute for Cell Engineering   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Par binding motif; Ring finger; RNF146

Indexed keywords

APURINIC ACID; DNA LIGASE III; HISTONE; IDUNA PROTEIN; KU ANTIGEN; KU86 PROTEIN; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NUCLEOLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RING FINGER PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

APYRIMIDINIC SITE; ARTICLE; BINDING AFFINITY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; RING FINGER MOTIF; UBIQUITINATION;

CELL LINE, TUMOR; CYTOPROTECTION; DNA DAMAGE; HUMANS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80052153015     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108799108     Document Type: Article

References (26)

1. Ciechanover A (1998) The ubiquitin-proteasome pathway: On protein death and cell life. EMBO J 17:7151-7160.
2. Di Fiore PP, Polo S, Hofmann K (2003) When ubiquitin meets ubiquitin receptors: A signalling connection. Nat Rev 4:491-497. (Pubitemid 36648594)
3. Hochstrasser M (2002) New structural clues to substrate specificity in the "ubiquitin system". Mol Cell 9:453-454.
4. Harper JW (2002) A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends Cell Biol 12:104-107.
5. Prudden J, et al. (2007) SUMO-targeted ubiquitin ligases in genome stability. EMBO J 26:4089-4101. (Pubitemid 47462097)
6. Krishnakumar R, Kraus WL (2010) The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets. Mol Cell 39:8-24.
7. Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG (2010) PARP inhibition: PARP1 and beyond. Nat Rev Cancer 10:293-301.
8. Schreiber V, Dantzer F, Ame JC, de Murcia G (2006) Poly(ADP-ribose): Novel functions for an old molecule. Nat Rev 7:517-528. (Pubitemid 44036457)
9. Gagne JP, et al. (2008) Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes. Nucleic Acids Res 36:6959-6976.
10. Andrabi SA, et al. (2006) Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci USA 103:18308-18313. (Pubitemid 44871654)
11. Wang Y, et al. (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal 4:ra20.
12. Yu SW, et al. (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103:18314-18319.
13. Yu SW, et al. (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297:259-263.
14. Hong SJ, Li H, Becker KG, Dawson VL, Dawson TM (2004) Identification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci USA 101:2145-2150. (Pubitemid 38229029)
15. Andrabi SA, et al. (2011) Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with parthanatos (poly (ADP-ribose) dependent cell death). Nat Med, in press.
16. Gold B, et al. (2008) Genome-wide association study provides evidence for a breast cancer risk locus at 6q22. Proc Natl Acad Sci USA 105:4340-4345. (Pubitemid 351754382)
17. Kirchhoff T, et al. (2009) The 6q22. 33 locus and breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 18:2468-2475.
18. Menachem TD, Laitman Y, Kaufman B, Friedman E (2009) The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women. Fam Cancer 8:399-402.
19. Woelk T, et al. (2006) Molecular mechanisms of coupled monoubiquitination. Nat Cell Biol 8:1246-1254. (Pubitemid 44660589)
20. Olive PL, Durand RE, Banath JP, Johnston PJ (2001) Analysis of DNA damage in individual cells. Methods Cell Biol 64:235-249.
21. Pleschke JM, Kleczkowska HE, Strohm M, Althaus FR (2000) Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem 275:40974-40980. (Pubitemid 32054922)
22. Wang Y, Dawson VL, Dawson TM (2009) Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 218:193-202.
23. Chou DM, et al. (2010) A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci USA 107:18475-18480.
24. Zhang Y, et al. (2011) RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol 13:623-629.
25. Ahel I, et al. (2008) Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature 451:81-85.
26. Aravind L (2001) The WWE domain: A common interaction module in protein ubiquitination and ADP ribosylation. Trends Biochem Sci 26:273-275.