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Volumn 141, Issue 3, 2011, Pages 1036-1045

P53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis

Author keywords

Cell Death; Crohn's Disease; IBD; Signaling; UC

Indexed keywords

BIM PROTEIN; CASPASE 3; CASPASE 9; DEXTRAN SULFATE; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN;

EID: 80052120071     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.05.032     Document Type: Article
Times cited : (72)

References (47)
  • 1
    • 0028589378 scopus 로고
    • Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
    • P.A. Hall, P.J. Coates, and B. Ansari Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis J Cell Sci 107 Pt 12 1994 3569 3577
    • (1994) J Cell Sci , vol.107 , Issue.PART 12 , pp. 3569-3577
    • Hall, P.A.1    Coates, P.J.2    Ansari, B.3
  • 2
    • 0017739418 scopus 로고
    • Extreme sensitivity of some intestinal crypt cells to X and γ irradiation
    • C.S. Potten Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation Nature 269 1977 518 521 (Pubitemid 8245145)
    • (1977) Nature , vol.269 , Issue.5628 , pp. 518-521
    • Potten, C.S.1
  • 3
    • 0020674141 scopus 로고
    • Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation
    • K. Ijiri, and C.S. Potten Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation Br J Cancer 47 1983 175 185 (Pubitemid 13185479)
    • (1983) British Journal of Cancer , vol.47 , Issue.2 , pp. 175-185
    • Ijiri, K.1    Potten, C.S.2
  • 4
    • 0023151768 scopus 로고
    • Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents
    • K. Ijiri, and C.S. Potten Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents Br J Cancer 55 1987 113 123 (Pubitemid 17021671)
    • (1987) British Journal of Cancer , vol.55 , Issue.2 , pp. 113-123
    • Ijiri, K.1    Potten, C.S.2
  • 5
    • 0029823381 scopus 로고    scopus 로고
    • Apoptosis of crypt epithelial cells in ulcerative colitis
    • DOI 10.1002/(SI CI)1096-9896(199610)18 0:2<152::AID-PATH6 49>3.0.CO;2-Y
    • M. Iwamoto, T. Koji, and K. Makiyama Apoptosis of crypt epithelial cells in ulcerative colitis J Pathol 180 1996 152 159 (Pubitemid 26370180)
    • (1996) Journal of Pathology , vol.180 , Issue.2 , pp. 152-159
    • Iwamoto, M.1    Koji, T.2    Makiyama, K.3    Kobayashi, N.4    Nakane, P.K.5
  • 7
    • 7444238212 scopus 로고    scopus 로고
    • T-cell-induced mucosal damage in the intestine
    • DOI 10.1097/00001574-200411000-00013
    • K. Croitoru, and P. Zhou T-cell-induced mucosal damage in the intestine Curr Opin Gastroenterol 20 2004 581 586 (Pubitemid 39447168)
    • (2004) Current Opinion in Gastroenterology , vol.20 , Issue.6 , pp. 581-586
    • Croitoru, K.1    Zhou, P.2
  • 9
    • 0036239652 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial cell Apoptosis and the pathogenesis of inflammatory bowel disorders
    • DOI 10.1097/00005176-200203000-00005
    • F.M. Ruemmele, E.G. Seidman, and M.J. Lentze Regulation of intestinal epithelial cell apoptosis and the pathogenesis of inflammatory bowel disorders J Pediatr Gastroenterol Nutr 34 2002 254 260 (Pubitemid 34437515)
    • (2002) Journal of Pediatric Gastroenterology and Nutrition , vol.34 , Issue.3 , pp. 254-260
    • Ruemmele, F.M.1    Seidman, E.G.2    Lentze, M.J.3
  • 10
    • 70549107710 scopus 로고    scopus 로고
    • Mitochondrial cell death effectors
    • D. Brenner, and T.W. Mak Mitochondrial cell death effectors Curr Opin Cell Biol 21 2009 871 877
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 871-877
    • Brenner, D.1    Mak, T.W.2
  • 11
    • 0037376788 scopus 로고    scopus 로고
    • Cell surface death receptor signaling in normal and cancer cells
    • DOI 10.1016/S1044-579X(02)00131-1, PII S1044579X02001311
    • N. Ozoren, and W.S. El-Deiry Cell surface death receptor signaling in normal and cancer cells Semin Cancer Biol 13 2003 135 147 (Pubitemid 36321814)
    • (2003) Seminars in Cancer Biology , vol.13 , Issue.2 , pp. 135-147
    • Ozoren, N.1    El-Deiry, W.S.2
  • 12
    • 0034280579 scopus 로고    scopus 로고
    • Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways
    • X.M. Yin Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways Cell Res 10 2000 161 167
    • (2000) Cell Res , vol.10 , pp. 161-167
    • Yin, X.M.1
  • 13
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • D.W. Meek Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9 2009 714 723
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 14
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • DOI 10.1038/sj.onc.1208615
    • S.L. Harris, and A.J. Levine The p53 pathway: positive and negative feedback loops Oncogene 24 2005 2899 2908 (Pubitemid 40638098)
    • (2005) Oncogene , vol.24 , Issue.17 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 15
    • 0030812174 scopus 로고    scopus 로고
    • Apoptosis in small intestinal epithelia from p53-null mice: Evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation
    • DOI 10.1038/sj.onc.1201126
    • A.J. Merritt, T.D. Allen, and C.S. Potten Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation Oncogene 14 1997 2759 2766 (Pubitemid 27313407)
    • (1997) Oncogene , vol.14 , Issue.23 , pp. 2759-2766
    • Merritt, A.J.1    Allen, T.D.2    Potten, C.S.3    Hickman, J.A.4
  • 16
    • 0034601420 scopus 로고    scopus 로고
    • Different impact of p53 and p21 on the radiation response of mouse tissues
    • E.A. Komarova, K. Christov, and A.I. Faerman Different impact of p53 and p21 on the radiation response of mouse tissues Oncogene 19 2000 3791 3798 (Pubitemid 30621185)
    • (2000) Oncogene , vol.19 , Issue.33 , pp. 3791-3798
    • Komarova, E.A.1    Christov, K.2    Faerman, A.I.3    Gudkov, A.V.4
  • 17
    • 2442681614 scopus 로고    scopus 로고
    • Dual effect of p53 on radiation sensitivity in vivo: P53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
    • DOI 10.1038/sj.onc.1207494
    • E.A. Komarova, R.V. Kondratov, and K. Wang Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice Oncogene 23 2004 3265 3271 (Pubitemid 38669816)
    • (2004) Oncogene , vol.23 , Issue.19 , pp. 3265-3271
    • Komarova, E.A.1    Kondratov, R.V.2    Wang, K.3    Christov, K.4    Golovkina, T.V.5    Goldblum, J.R.6    Gudkov, A.V.7
  • 19
    • 77949655884 scopus 로고    scopus 로고
    • Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis
    • W. Qiu, B. Leibowitz, and L. Zhang Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis Oncogene 29 2010 1622 1632
    • (2010) Oncogene , vol.29 , pp. 1622-1632
    • Qiu, W.1    Leibowitz, B.2    Zhang, L.3
  • 20
    • 0037314548 scopus 로고    scopus 로고
    • Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: Full-length gene sequencing in microdissected single crypts
    • DOI 10.1002/path.1264
    • T. Yoshida, T. Mikami, and H. Mitomi Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts J Pathol 199 2003 166 175 (Pubitemid 36176022)
    • (2003) Journal of Pathology , vol.199 , Issue.2 , pp. 166-175
    • Yoshida, T.1    Mikami, T.2    Mitomi, H.3    Okayasu, I.4
  • 22
    • 0031886716 scopus 로고    scopus 로고
    • Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma
    • DOI 10.1016/S0046-8177(98)90222-2
    • F. Fogt, A.O. Vortmeyer, and H. Goldman Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma Hum Pathol 29 1998 131 136 (Pubitemid 28099507)
    • (1998) Human Pathology , vol.29 , Issue.2 , pp. 131-136
    • Fogt, F.1    Vortmeyer, A.O.2    Goldman, H.3    Giordano, T.J.4    Merino, M.J.5    Zhuang, Z.6
  • 25
    • 74049140048 scopus 로고    scopus 로고
    • Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways
    • A.J. Schetter, N.H. Heegaard, and C.C. Harris Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways Carcinogenesis 31 2010 37 49
    • (2010) Carcinogenesis , vol.31 , pp. 37-49
    • Schetter, A.J.1    Heegaard, N.H.2    Harris, C.C.3
  • 28
    • 0028171234 scopus 로고
    • P53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma
    • N. Harpaz, A.L. Peck, and J. Yin p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma Hum Pathol 25 1994 1069 1074
    • (1994) Hum Pathol , vol.25 , pp. 1069-1074
    • Harpaz, N.1    Peck, A.L.2    Yin, J.3
  • 29
    • 38649085044 scopus 로고    scopus 로고
    • P53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease
    • DOI 10.1007/s10620-007-9886-1
    • J.W. Nathanson, N.E. Yadron, and J. Farnan p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease Dig Dis Sci 53 2008 474 480 (Pubitemid 351170026)
    • (2008) Digestive Diseases and Sciences , vol.53 , Issue.2 , pp. 474-480
    • Nathanson, J.W.1    Yadron, N.E.2    Farnan, J.3    Kinnear, S.4    Hart, J.5    Rubin, D.T.6
  • 34
    • 69049103034 scopus 로고    scopus 로고
    • PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis
    • P. Wang, W. Qiu, and C. Dudgeon PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis Cell Death Differ 16 2009 1192 1202
    • (2009) Cell Death Differ , vol.16 , pp. 1192-1202
    • Wang, P.1    Qiu, W.2    Dudgeon, C.3
  • 35
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • DOI 10.1016/j.cell.2004.07.013, PII S0092867404006713
    • F.R. Greten, L. Eckmann, and T.F. Greten IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 2004 285 296 (Pubitemid 39061110)
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.-W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 36
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • DOI 10.1056/NEJMra020831
    • D.K. Podolsky Inflammatory bowel disease N Engl J Med 347 2002 417 429 (Pubitemid 34851835)
    • (2002) New England Journal of Medicine , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 37
    • 0031776721 scopus 로고    scopus 로고
    • Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells
    • J. Grossmann, S. Mohr, and E.G. Lapentina Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells Am J Physiol 274 1998 G1117 G1124
    • (1998) Am J Physiol , vol.274
    • Grossmann, J.1    Mohr, S.2    Lapentina, E.G.3
  • 38
    • 19444373939 scopus 로고    scopus 로고
    • Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: Ulcerative colitis shows specific p53- and EGFR expression alterations
    • DOI 10.1007/s10350-004-0831-5
    • F. Sipos, B. Molnar, and T. Zagoni Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and EGFR expression alterations Dis Colon Rectum 48 2005 775 786 (Pubitemid 40880726)
    • (2005) Diseases of the Colon and Rectum , vol.48 , Issue.4 , pp. 775-786
    • Sipos, F.1    Molnar, B.2    Zagoni, T.3    Berczi, L.4    Tulassay, Z.5
  • 39
    • 33646093708 scopus 로고    scopus 로고
    • P53 Biological network: At the crossroads of the cellular-stress response pathway and molecular carcinogenesis
    • S.P. Hussain, and C.C. Harris p53 Biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis J Nippon Med Sch 73 2006 54 64
    • (2006) J Nippon Med Sch , vol.73 , pp. 54-64
    • Hussain, S.P.1    Harris, C.C.2
  • 40
    • 34247504546 scopus 로고    scopus 로고
    • P53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion
    • DOI 10.1136/gut.2006.101683
    • B. Wu, W. Qiu, and P. Wang p53 Independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion Gut 56 2007 645 654 (Pubitemid 46662930)
    • (2007) Gut , vol.56 , Issue.5 , pp. 645-654
    • Wu, B.1    Qiu, W.2    Wang, P.3    Yu, H.4    Cheng, T.5    Zambetti, G.P.6    Zhang, L.7    Yu, J.8
  • 41
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • J. Yu, and L. Zhang PUMA, a potent killer with or without p53 Oncogene 27 Suppl 1 2008 S71 S83
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Yu, J.1    Zhang, L.2
  • 42
    • 0346725848 scopus 로고    scopus 로고
    • The effect of specific caspase inhibitors on TNF-α and butyrate-induced apoptosis of intestinal epithelial cells
    • DOI 10.1016/j.yexcr.2003.08.005
    • S.A. Jones, R.N. Butler, and I.R. Sanderson The effect of specific caspase inhibitors on TNF-α and butyrate-induced apoptosis of intestinal epithelial cells Exp Cell Res 292 2004 29 39 (Pubitemid 38058261)
    • (2004) Experimental Cell Research , vol.292 , Issue.1 , pp. 29-39
    • Jones, S.A.1    Butler, R.N.2    Sanderson, I.R.3    Wilson, J.W.4
  • 43
    • 0031770767 scopus 로고    scopus 로고
    • TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53
    • DOI 10.1002/(SI CI)1521-4141(199811)28:1 1<3499::AID-IMMU34 99>3.0.CO;2-Q
    • P.F. Piguet, C. Vesin, and J. Guo TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53 Eur J Immunol 28 1998 3499 3505 (Pubitemid 28510760)
    • (1998) European Journal of Immunology , vol.28 , Issue.11 , pp. 3499-3505
    • Piguet, P.F.1    Vesin, C.2    Guo, J.3    Donati, Y.4    Barazzone, C.5
  • 44
    • 0031937067 scopus 로고    scopus 로고
    • Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal
    • DOI 10.1002/(SIC I)1521-4141(199802)2 8:02<730::AID-IM MU730>3.0.CO;2-U
    • D. Guy-Grand, J.P. DiSanto, and P. Henchoz Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal Eur J Immunol 28 1998 730 744 (Pubitemid 28101750)
    • (1998) European Journal of Immunology , vol.28 , Issue.2 , pp. 730-744
    • Guy-Grand, D.1    DiSanto, J.P.2    Henchoz, P.3    Malassis-Seris, M.4    Vassalli, P.5
  • 45
    • 0035797473 scopus 로고    scopus 로고
    • Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
    • DOI 10.1038/sj.onc.1204484
    • T.F. Burns, E.J. Bernhard, and W.S. El-Deiry Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo Oncogene 20 2001 4601 4612 (Pubitemid 32762432)
    • (2001) Oncogene , vol.20 , Issue.34 , pp. 4601-4612
    • Burns, T.F.1    Bernhard, E.J.2    El-Deiry, W.S.3


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