p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease

Digestive Diseases and Sciences

Volumn 53, Issue 2, 2008, Pages 474-480

  Nathanson, Jeffrey W ^a   Yadron, Nicole E ^a   Farnan, Jeanne ^a   Kinnear, Sydney ^a   Hart, John ^a   Rubin, David T ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

Colon cancer; Crohn's disease; Dysplasia; p53; Tumor suppressor gene

Indexed keywords

PROTEIN P53;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON BIOPSY; COLORECTAL CANCER; CONTROLLED STUDY; CROHN DISEASE; DISEASE COURSE; DISEASE PREDISPOSITION; DYSPLASIA; FEMALE; FOLLOW UP; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MALE; MEDICAL ASSESSMENT; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; PROCTOCOLECTOMY; STAINING;

ADULT; CROHN DISEASE; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK ASSESSMENT;

EID: 38649085044     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9886-1     Document Type: Article

References (60)

1. Ekbom A, Helmick C, Zack M, Adami HO (1990) Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 323:1228-1233
2. Ekbom A, Helmick C, Zack M, Adami HO (1990) Increased risk of large-bowel cancer in Crohn's disease with colonic involvement. Lancet 336:357-359
3. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN (1994) Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 35:1590-1592
4. Jess T, Gamborg M, Matzen P, Munkholm P, Sorensen TI (2005) Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol 100:2724-2729
5. Sachar DB (1994) Cancer in Crohn's disease: dispelling the myths. Gut 35:1507-1508
6. Itzkowitz S (2003) Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice. J Clin Gastroenterol 36:S70-S74 discussion S94-S96
7. Lane DP (1992) Cancer. p53, guardian of the genome Nature 358:15-16
8. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53
9. Carson DA, Lois A (1995) Cancer progression and p53. Lancet 346:1009-1011
10. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532
11. Lashner BA, Bauer WM, Rybicki LA, Goldblum JR (2003) Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. Am J Gastroenterol 98:1423-1427
12. Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, Burmer GC (1994) Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroenterology 107:369-378
13. Ajioka Y, Watanabe H, Matsuda K (1995) Over-expression of p53 protein in neoplastic changes in ulcerative colitis: immunohistochemical study. J Gastroenterol 30(Suppl 8):33-35
14. Burmer GC, Crispin DA, Kolli VR, Haggitt RC, Kulander BG, Rubin CE, Rabinovitch PS (1991) Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis. Cancer Commun 3:167-172
15. Burmer GC, Rabinovitch PS, Haggitt RC, Crispin DA, Brentnall TA, Kolli VR, Stevens AC, Rubin CE (1992) Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology 103:1602-1610
16. Greenwald BD, Harpaz N, Yin J, Huang Y, Tong Y, Brown VL, McDaniel T, Newkirk C, Resau JH, Meltzer SJ (1992) Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res 52:741-745
17. Harpaz N, Peck AL, Yin J, Fiel I, Hontanosas M, Tong TR, Laurin JN, Abraham JM, Greenwald BD, Meltzer SJ (1994) p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma. Hum Pathol 25:1069-1074
18. Taylor HW, Boyle M, Smith SC, Bustin S, Williams NS (1993) Expression of p53 in colorectal cancer and dysplasia complicating ulcerative colitis. Br J Surg 80:442-444
19. Yin J, Harpaz N, Tong Y, Huang Y, Laurin J, Greenwald BD, Hontanosas M, Newkirk C, Meltzer SJ (1993) p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 104:1633-1639
20. Ilyas M, Talbot IC (1995) p53 expression in ulcerative colitis: a longitudinal study. Gut 37:802-804
21. Holzmann K, Klump B, Borchard F, Hsieh CJ, Kuhn A, Gaco V, Gregor M, Porschen R: (1998) Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis. Int J Cancer 76:1-6
22. Sato A, MacHinami R (1999) p53 immunohistochemistry of ulcerative colitis-associated with dysplasia and carcinoma. Pathol Int 49:858-868
23. Lashner BA, Shapiro BD, Husain A, Goldblum JR (1999) Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis. Am J Gastroenterol 94:456-462
24. Warren S, Sommers S (1948) Cicatrizing enteritis (regional enteritis) as a pathologic entity: analysis of one hundred and twenty cases. Am J Pathol 24:475-501
25. Persson PG, Karlen P, Bernell O, Leijonmarck CE, Brostrom O, Ahlbom A, Hellers G: (1994) Crohn's disease and cancer: a population-based cohort study. Gastroenterology 107:1675-1679
26. Gillen CD, Andrews HA, Prior P, Allan RN (1994) Crohn's disease and colorectal cancer. Gut 35:651-655
27. Gyde SN, Prior P, Macartney JC, Thompson H, Waterhouse JA, Allan RN (1980) Malignancy in Crohn's disease. Gut 21:1024-1029
28. Weedon DD, Shorter RG, Ilstrup DM, Huizenga KA, Taylor WF (1973) Crohn's disease and cancer. N Engl J Med 289:1099-1103
29. Kilgore SP, Sigel JE, Goldblum JR (2000) Hyperplastic-like mucosal change in Crohn's disease: an unusual form of dysplasia? Mod Pathol 13:797-801
30. Koda K, Yoshino G, Honda S, Watanabe F, Sugimura H (2000) Adenocarcinoma of the rectum with various grades of atypia in association with Crohn's disease: a case report and immunohistochemistry of p53 and Ki-67. Pathol Int 50:318-326
31. Tiszlavicz L, Kapin M, Varkonyi A, Lorincz A, Bartyik K, Varkonyi T (2001) Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood. Eur J Pediatr 160:168-172
32. Fogt F, Vortmeyer AO, Goldman H, Giordano TJ, Merino MJ, Zhuang Z (1998) Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma. Hum Pathol 29:131-136
33. Sjoqvist U, Befrits R, Soderlund S, Ost A, Karlen P, Tribukait B, Rubio C, Rutgeerts P, Geboes K, Lofberg R (2005) Colorectal cancer in colonic Crohn's disease-high frequency of DNA-aneuploidy. Anticancer Res 25:4393-4397
34. Lofberg R, Brostrom O, Karlen P, Ost A, Tribukait B (1991) Carcinoma and DNA aneuploidy in Crohn's colitis-a histological and flow cytometric study. Gut 32:900-9004
35. Markowitz J, McKinley M, Kahn E, Stiel L, Rosa J, Grancher K, Daum F (1997) Endoscopic screening for dysplasia and mucosal aneuploidy in adolescents and young adults with childhood onset colitis. Am J Gastroenterol 92:2001-2006
36. Heinzlmann M, Lang SM, Neynaber S, Reinshagen M, Emmrich J, Stratakis DF, Heldwein W, Wiebecke B, Loeschke K (2002) Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease. Eur J Gastroenterol Hepatol 14:1061-1066
37. Lofberg R, Brostrom O, Karlen P, Ost A, Tribukait B (1992) DNA aneuploidy in ulcerative colitis: reproducibility, topographic distribution, and relation to dysplasia. Gastroenterology 102:1149-1154
38. Lindberg JO, Stenling RB, Rutegard JN (1999) DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis. Br J Surg 86:947-950
39. Befrits R, Hammarberg C, Rubin CE (1994) DNA aneuploidy and histologic dysplasia in long-standing ulcerative colitis: A 10-year follow-up study. Dis Colon Rectum 37:313-320
40. Rubin CE, Haggitt RC, Burmer GC, Brentnall TA, Stevens AC, Levine DS, Dean PJ, Kimmey M, Perera DR, Rabinovitch PS (1992) DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 103:1611-1620
41. Karlen P, Young E, Brostrom O, Lofberg R, Tribukait B, Ost K, Bodian C, Itzkowitz S (1998) Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: relation to dysplasia and DNA aneuploidy. Gastroenterology 115:1395-1404
42. Itzkowitz SH, Young E, Dubois D, Harpaz N, Bodian C, Chen A, Sachar DB (1996) Sialosyl-Tn antigen is prevalent and precedes dysplasia in ulcerative colitis: a retrospective case-control study. Gastroenterology 110:694-704
43. Agoff SN, Brentnall TA, Crispin DA, Taylor SL, Raaka S, Haggitt RC, Reed MW, Afonina IA, Rabinovitch PS, Stevens AC, Feng Z, Bronner MP (2000) The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am J Pathol 157:737-745
44. Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR (1996) Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 56:1237-1240
45. Heinen CD, Noffsinger AE, Belli J, Straughen J, Fischer J, Groden J, Fenoglio-Preiser CM (1997) Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation. Genes Chromosomes Cancer 19:170-175
46. Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ (2000) Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res 60:4864-4868
47. Eaden JA, Mayberry JF (2002) Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease. Gut 51 Suppl 5:V10-V12
48. Itzkowitz SH (1997) Inflammatory bowel disease and cancer. Gastroenterol Clin North Am 26:129-139
49. Vemulapalli R, Lance P (1994) Cancer surveillance in ulcerative colitis: more of the same or progress? Gastroenterology 107:1196-1199
50. Lynch DA, Lobo AJ, Sobala GM, Dixon MF, Axon AT (1993) Failure of colonoscopic surveillance in ulcerative colitis. Gut 34:1075-1080
51. Connell WR, Lennard-Jones JE, Williams CB, Talbot IC, Price AB, Wilkinson KH (1994) Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. Gastroenterology 107:934-944
52. Bernstein CN, Shanahan F, Weinstein WM (1994) Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? Lancet 343:71-74
53. van Hogezand RA, Eichhorn RF, Choudry A, Veenendaal RA, Lamers CB (2002) Malignancies in inflammatory bowel disease: fact or fiction? Scand J Gastroenterol Suppl (236):48-53
54. Munkholm P, Langholz E, Davidsen M, Binder V (1993) Intestinal cancer risk and mortality in patients with Crohn's disease. Gastroenterology 105:1716-1723
55. Bernstein CN, Blanchard JF, Kliewer E, Wajda A (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91:854-862
56. Ekbom A, Helmick C, Zack M, Adami HO (1991) Extracolonic malignancies in inflammatory bowel disease. Cancer 67:2015-2019
57. Gollop JH, Phillips SF, Melton 3rd LJ, Zinsmeister AR (1988) Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982. Gut 29:49-56
58. Petras RE, Mir-Madjlessi SH, Farmer RG (1987) Crohn's disease and intestinal carcinoma. A report of 11 cases with emphasis on associated epithelial dysplasia. Gastroenterology 93:1307-1314
59. Richards ME, Rickert RR, Nance FC (1989) Crohn's disease-associated carcinoma. A poorly recognized complication of inflammatory bowel disease. Ann Surg 209:764-773
60. Uesugi H, Mitomi H, Sada M, Takahashi H, Kobayashi K, Igarashi M, Katsumata T, Ihara A, Ohtani Y, Ikeda S, Okayasu I (1999) A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses. Scand J Gastroenterol 34:1162-1167