Oligonucleotide conjugates by means of copper-free click chemistry - Expanding the repertoire of strained cyclooctyne phosphoramidites

Synthesis

Volumn , Issue 17, 2011, Pages 2724-2732

  Vandelft, Pieter ^a   Vanschie, Evert ^a   Meeuwenoord, Nico J ^a   Overkleeft, Herman S ^a   Van Der Marel, Gijsbert A ^a   Filippov, Dmitri V ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

bioconjugates; conjugates; oligonucleotides; phosphoramidites; strain induced cycloaddition

Indexed keywords

BIOCONJUGATES; BUILDING BLOCKES; CLICK CHEMISTRY; CONJUGATES; OLIGONUCLEOTIDE CONJUGATES; OLIGONUCLEOTIDE SYNTHESIS; PHOSPHORAMIDITES; SOLID-PHASE; STRAIN-INDUCED CYCLOADDITION;

NUCLEIC ACIDS;

OLIGONUCLEOTIDES;

(6,6' DIHEXYLDISULFIDE) (1 CARBONIC ACID 7,8 DIDEHYDRO 1,2:5,6 DIBENZOCYCLOOCTEN 3 YL ESTER) 1,1' DIAMINE; (6,6' DIHEXYLDISULFIDE) 1,1' DIAMINE; 6 (PYRIDIN 2 YLDISULFANYL)HEXAN 1 OL; 6' (1 CARBONIC ACID 7,8 DIDEHYDRO 1,2:5,6 DIBENZOCYCLOOCTEN 3 YL ESTER 1' HEXAMIDE)DISULFANYL 6 HEXANOL; 6' (1 CARBONIC ACID 7,8 DIDEHYDRO 1,2:5,6 DIBENZOCYCLOOCTEN 3 YL ESTER 1' HEXAMIDE)DISULFANYL 6 HEXYL 1 (2 CYANOETHOXY N,N DIISOPROPYLAMINO)PHOSPHORAMIDITE; [6 [(TERT BUTOXYCARBONYL)AMINO]HEXYL]ETHANETHIONATE; CARBONIC ACID 7,8 DIDEHYDRO 1,2:5,6 DIBENZOCYCLOOCTEN 3 YL ESTER, 6' [3 O (4,4' DIMETHOXYTRITYL)PROPANOXY N,N' DIISOPROPYLAMINO]PHOSPHINOOXY 1' AMIDE; CARBONIC ACID 7,8 DIDEHYDRO 1,2:5,6 DIBENZOCYCLOOCTEN 3 YL ESTER, 6' [5' O (4,4' DIMETHOXYTRITYL) 3' THYMIDINE N,N' DIISOPROPYLAMINO]PHOSPHINOOXY 1' AMIDE; COPPER; CYCLOOCTYNE PHOSPHORAMIDOUS ACID DERIVATIVE; DI TERT BUTYL (6,6' DIHEXYLDISULFIDE) 1,1' DICARBAMATE; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; TERT BUTYL (6 HYDROXYHEXYL)CARBAMATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CLICK CHEMISTRY; CONJUGATION; RNA INTERFERENCE; SYNTHESIS;

EID: 80052048207     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260104     Document Type: Article

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