Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

European Journal of Pharmacology

Volumn 667, Issue 1-3, 2011, Pages 322-329

  Ilic, Spomenko ^a   Drmic, Domagoj ^a   Zarkovic, Kamelija ^a   Kolenc, Danijela ^a   Brcic, Luka ^a   Radic, Bozo ^a   Djuzel, Viktor ^a   Blagaic, Alenka Boban ^a   Romic, Zeljko ^a   Dzidic, Senka ^a   Kalogjera, Livije ^a   Seiwerth, Sven ^a   Sikiric, Predrag ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Gastric lesion; Hepatic encephalopathy; Hepatomegaly; Ibuprofen; Pentadecapeptide BPC 157; Rat; Sedation unconsciousness

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BEHAVIOR DISORDER; BRAIN EDEMA; CONTROLLED STUDY; DRUG EFFECT; HEPATIC ENCEPHALOPATHY; HEPATOMEGALY; HISTOPATHOLOGY; LIVER PROTECTION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; STOMACH LESION; STOMACH PROTECTION; UNCONSCIOUSNESS; WEIGHT GAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTI-ULCER AGENTS; BEHAVIOR, ANIMAL; BRAIN; BRAIN INJURIES; HEPATIC ENCEPHALOPATHY; HEPATOMEGALY; IBUPROFEN; LIVER; MALE; MOLECULAR SEQUENCE DATA; ORGAN SIZE; PEPTIDES; RATS; RATS, WISTAR; STOMACH; STOMACH DISEASES;

EID: 80052032001     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.038     Document Type: Article

References (66)

1. S. Ahboucha, W. Jiang, N. Chatauret, O. Mamer, G.B. Baker, and R.F. Butterworth Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis Neurogastroenterol. Motil. 20 2008 949 957 (Pubitemid 352019719)
2. Q. Aziz, and D.G. Thompson Brain-gut axis in health and disease Gastroenterology 114 1998 559 578 (Pubitemid 28141202)
3. A.M. Bendele, J.F. Hulman, S. White, C. Brodhecker, and R.A. Bendele Hepatocellular proliferation in ibuprofen-treated mice Toxicol. Pathol. 21 1993 15 20 (Pubitemid 23204904)
4. M. Bilic, Z. Bumber, A.B. Blagaic, L. Batelja, S. Seiwerth, and P. Sikiric The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice Burns 31 2005 310 315 (Pubitemid 40363939)
5. B.M. Bilir, and N. Bilir Pharmacology and medical management of hepatic cirrhosis and fibrosis G. Friedman, E.D. Jacobson, R.W. McCallum, Gastrointestinal pharmacology and therapeutics 1997 Lippincontt-Raven Publishers Philadelphia 449 464
6. A.B. Blagaic, V. Blagaic, Z. Romic, and P. Sikiric The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice Eur. J. Pharmacol. 499 2004 285 290 (Pubitemid 39233667)
7. Blagaic A. Boban, V. Blagaic, M. Mirt, N. Jelovac, G. Dodig, R. Rucman, M. Petek, B. Turkovic, T. Anic, M. Dubovecak, M. Staresinic, S. Seiwerth, and P. Sikiric Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats Eur. J. Pharmacol. 512 2005 173 179 (Pubitemid 40544351)
8. A. Boban-Blagaic, V. Blagaic, Z. Romic, N. Jelovac, G. Dodig, R. Rucman, M. Petek, B. Turkovic, S. Seiwerth, and P. Sikiric The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice The effect of N(G)-nitro-l-arginine methyl ester and L-arginine Med. Sci. Monit. 12 2006 BR36 BR45
9. J.V. Castell, A. Larrauri, and M.J. Gómez-Lechón A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen Xenobiotica 18 1988 737 745
10. O. Cauli, R. Rodrigo, B. Piedrafita, J. Boix, and V. Felipo Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts Hepatology 46 2007 514 519 (Pubitemid 47344787)
11. C.Y. Chan, F.Y. Lee, T.F. Wang, S.W. Huang, F.Y. Chang, R.H. Lu, Y.C. Chen, S.S. Wang, H.C. Huang, and S.D. Lee Lack of detrimental or therapeutic effects of cyclooxygenase inhibition in bile duct-ligated rats with hepatic encephalopathy J. Gastroenterol. Hepatol. 21 2006 1483 1487
12. C.J. Chu, C.C. Hsiao, T.F. Wang, C.Y. Chan, F.Y. Lee, F.Y. Chang, Y.C. Chen, H.C. Huang, S.S. Wang, and S.D. Lee Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure World J. Gastroenterol. 11 2005 232 236
13. A. Denda, T. Endoh, W. Kitayama, Q. Tang, O. Noguchi, Y. Kobayashi, H. Akai, E. Okajima, T. Tsujiuchi, M. Tsutsumi, D. Nakae, and Y. Konishi Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats Carcinogenesis 18 1997 1921 1930 (Pubitemid 28132376)
14. I. Dobric, P. Drvis, I. Petrovic, D. Shejbal, L. Brcic, A.B. Blagaic, L. Batelja, M. Sever, N. Kokic, A. Tonkic, I. Zoricic, S. Mise, M. Staresinic, B. Radic, A. Jakir, J. Babel, S. Ilic, T. Vuksic, I. Jelic, T. Anic, S. Seiwerth, and P. Sikiric Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157 J. Pharmacol. Sci. 104 2007 7 18 (Pubitemid 46790311)
15. T.M. Donohue Jr. Alcohol-induced steatosis in liver cells World J. Gastroenterol. 13 2007 4974 4978 (Pubitemid 47496830)
16. R.J. Fontana Acute liver failure including acetaminophen overdose Med. Clin. North Am. 92 2008 761 794 (Pubitemid 351822355)
17. Z. Grabarevic, M. Tisljar, B. Artukovic, M. Bratulic, P. Dzaja, S. Seiwerth, P. Sikiric, J. Peric, D. Geres, and J. Kos The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks J. Physiol. (Paris) 91 1997 139 149 (Pubitemid 27467018)
18. S.A. Hamburger, and P.B. McCay Spin trapping of ibuprofen radicals:evidence that ibuprofen is a hydroxyl radical scavenger Free Rad. Res. Commun. 9 1990 337 342 (Pubitemid 20376787)
19. H.C. Huang, S.S. Wang, F.Y. Lee, C.Y. Chan, F.Y. Chang, H.C. Lin, C.J. Chu, Y.C. Chen, and S.D. Lee Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy J. Gastroenterol. Hepatol. 23 2008 e236 e242
20. N. Jelovac, P. Sikiric, R. Rucman, M. Petek, D. Perovic, P. Konjevoda, A. Marovic, S. Seiwerth, Z. Grabarevic, J. Sumajstorcic, G. Dodig, and J. Peric A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine Biol. Psychiatry. 43 1998 511 519 (Pubitemid 28161296)
21. N. Jelovac, P. Sikiric, R. Rucman, M. Petek, A. Marovic, D. Perovic, S. Seiwerth, S. Mise, B. Turkovic, G. Dodig, P. Miklic, G. Buljat, and I. Prkacin Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats Eur. J. Pharmacol. 379 1999 19 31 (Pubitemid 29492943)
22. H. Kakuta, X. Zheng, H. Oda, S. Harada, Y. Sugimoto, K. Sasaki, and A. Tai Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage, design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor J. Med. Chem. 51 2008 2400 2411 (Pubitemid 351628501)
23. R. Klicek, M. Sever, B. Radic, D. Drmic, I. Kocman, I. Zoricic, T. Vuksic, M. Ivica, I. Barisic, S. Ilic, L. Berkopic, H. Vrcic, L. Brcic, A.B. Blagaic, M. Coric, I. Brcic, D.S. Rokotov, T. Anic, S. Seiwerth, and P. Sikiric Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736, Pliva), is effective in the healing of colocutaneous fistulas in rats: the role of NO-system J. Pharmacol. Sci. 108 2008 7 17
24. A.J. Knell, A.R. Davidson, R. Williams, B.D. Kantamaneni, and G. Curzon Dopamine and serotonin metabolism in hepatic encephalopathy Br. Med. J. 1 1974 549 551
25. A. Krivic, T. Anic, S. Seiwerth, D. Huljev, and P. Sikiric Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing and opposed corticosteroid aggravation J. Orthopaed. Res. 24 2006 982 989 (Pubitemid 43804933)
26. S. Laurent, J. Rahier, A.P. Geubel, J. Lerut, and Y. Horsmans Subfulminant hepatitis requiring liver transplantation following ibuprofen overdose Liver 20 2000 93 94 (Pubitemid 30095293)
27. R. Lazic, N. Gabric, I. Dekaris, D. Bosnar, A. Boban-Blagaic, and P. Sikiric Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats Coll. Antropol. 29 2005 321 325 (Pubitemid 40978287)
28. M. Lovric-Bencic, P. Sikiric, J.S. Hanzevacki, S. Seiwerth, D. Rogic, V. Kusec, G. Aralica, P. Konjevoda, L. Batelja, and A.B. Blagaic Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse J. Pharmacol. Sci. 95 2004 119 126
29. I. Manov, H. Motanis, I. Frumin, and T. Iancu Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects Acta Pharmacol. Sin. 27 2006 259 272 (Pubitemid 43357020)
30. K.D. Mullen, S. Birgisson, R.C. Gacad, and H. Conjeevaram Animal models of hepatic encephalopathy and hyperammonemia Adv. Exp. Med. Biol. 368 1994 1 10
31. T. Novinscak, L. Brcic, M. Staresinic, I. Jukic, B. Radic, D. Pevec, S. Mise, S. Tomasovic, I. Brcic, T. Banic, A. Jakir, G. Buljat, T. Anic, I. Zoricic, Z. Romic, S. Seiwerth, and P. Sikiric Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat Surg. Today 38 2008 716 725
32. T. Obata Dopamine efflux by MPTP and hydroxyl radical generation J. Neural. Transm. 109 2002 1159 1180 (Pubitemid 35013715)
33. M.T. Pritchard, S. Roychowdhury, M.R. McMullen, L. Guo, G.E. Arteel, and L.E. Nagy Early growth response-1 contributes to galactosamine/ lipopolysaccharideinduced acute liver injury in mice Am. J. Physiol. Gastrointest. Liver Physiol. 293 2007 G1124 G1133
34. I. Prkacin, G. Aralica, D. Perovic, J. Separovic, M. Gjurasin, M. Lovric-Bencic, D. Stancic-Rokotov, T. Ziger, T. Anic, P. Sikiric, S. Seiwerth, M. Staresinic, S. Mise, I. Rotkvic, V. Jagic, R. Rucman, M. Petek, B. Turkovic, A. Marovic, I. Sjekavica, B. Sebecic, A. Boban-Blagaic, and Z. Ivasovic Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats J. Physiol. (Paris) 95 2001 295 301 (Pubitemid 33020253)
35. I. Prkacin, J. Separovic, G. Aralica, D. Perovic, M. Gjurasin, M. Lovric-Bencic, D. Stancic-Rokotov, M. Staresinic, T. Anic, D. Mikus, P. Sikiric, S. Seiwerth, S. Mise, I. Rotkvic, V. Jagic, R. Rucman, M. Petek, B. Turkovic, A. Marovic, B. Sebecic, A. Boban-Blagaic, and N. Kokic Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10., PLD-116), and propranolol, but not ranitidine J. Physiol. (Paris) 95 2001 315 324 (Pubitemid 33020256)
36. I. Prkacin, M. Staresinic, S. Suknaic, J. Separovic, M. Lovric Bencic, D. Stancic Rokotov, G. Aralica, L. Batelja, A. Boban Blagaic, D. Perovic, R. Rucman, M. Petek, T. Anic, S. Seiwerth, and P. Sikiric Reduction of Doppler shift of otherwise increased blood flow velocity in v. cava inferior and v. portae of chronically alcohol drinking portal hypertensive rats by gastric pentadecapeptide BPC 157 (PL-10) Gastroenterology 122 2002 353
37. M. Ruenzi, M. Stolte, M. Veljaca, K. Oreskovic, J. Peterson, and Ulcerative Colitis Study Group A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis Gastroenterology 128 2005 A584
38. W.G. Schoonen, C.P. Kloks, J.P. Ploemen, M.J. Smit, P. Zandberg, G.J. Horbach, J.R. Mellema, C. Thijssen-Vanzuylen, A.C. Tas, J.H. van Nesselrooij, and J.T. Vogels Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity Toxicol. Sci. 98 2007 286 297 (Pubitemid 47078757)
39. B. Sebecic, V. Nikolic, P. Sikiric, S. Seiwerth, T. Sosa, L. Patrlj, Z. Grabarevic, R. Rucman, M. Petek, P. Konjevoda, S. Jadrijevic, D. Perovic, and M. Slaj Osteogenic effect of a gastric pentadecapeptide BPC 157, on the healing of segmental bone defect in rabbits. A comparison with bone marrow and autologous cortical bone implantation Bone 24 1999 195 202 (Pubitemid 29094561)
40. S. Seiwerth, P. Sikiric, Z. Grabarevic, I. Zoricic, M. Hanzevacki, D. Ljubanovic, V. Coric, P. Konjevoda, M. Petek, R. Rucman, B. Turkovic, D. Perovic, D. Mikus, S. Jandrijevic, M. Medvidovic, T. Tadic, B. Romac, J. Kos, J. Peric, and Z. Kolega BPC 157's effect on healing J. Physiol. (Paris) 91 1997 173 178 (Pubitemid 27467020)
41. D. Seveljevic-Jaran, S. Cuzic, M. Dominis-Kramaric, I. Glojnaric, V. Ivetic, S. Radosevic, and M.J. Parnham Accelerated healing of excisional skin wound by PL 14736 in alloxan-hyperglycemic rats Skin Pharmacol. Physiol. 19 2006 266 274 (Pubitemid 44329093)
42. P. Sikiric, M. Petek, R. Rucman, S. Seiwerth, Z. Grabarevic, I. Rotkvic, B. Turkovic, V. Jagic, B. Mildner, and M. Duvnjak A new gastric peptide BPC. An overview of stomach - organoprotection hypothesis and beneficial effect of BPC J. Physiol. (Paris) 87 1993 313 327 (Pubitemid 23343538)
43. P. Sikiric, S. Seiwerth, Z. Grabarevic, M. Petek, R. Rucman, B. Turkovic, I. Rotkvic, V. Jagic, M. Duvnjak, and S. Mise Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration A comparative study with dopamine agonists and somatostatin Life Sci. 53 1993 PL291 PL296
44. P. Sikiric, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, V. Jagic, B. Turkovic, I. Rotkvic, S. Mise, I. Zoricic, P. Konjevoda, D. Perovic, L. Jurina, J. Separovic, M. Hanzevacki, B. Artukovic, M. Bratulic, M. Tisljar, M. Gjurasin, P. Miklic, D. Stancic-Rokotov, Z. Slobodnjak, N. Jelovac, and A. Marovic The beneficial effect of BPC 157, a 15 aminoacid peptide BPC fragment, on gastric and duodenal lesion induced by restraint stress, cysteamine and 96% ethanol in rats A comparative study with H2 receptor antagonists, dopamine promoters and gut peptides Life Sci. 54 1994 PL63 PL68
45. P. Sikiric, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, V. Jagic, B. Turkovic, I. Rotkvic, S. Mise, I. Zoricic, M. Gjurasin, P. Konjevoda, J. Separovic, D. Ljubanovic, B. Artukovic, M. Bratulic, M. Tisljar, L. Jurina, G. Buljat, P. Miklic, and A. Marovic Beneficial effect of novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity Dig. Dis. Sci. 41 1996 1604 1614 (Pubitemid 26285747)
46. P. Sikiric, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, V. Jagic, B. Turkovic, I. Rotkvic, S. Mise, I. Zoricic, P. Konjevoda, D. Perovic, V. Simicevic, J. Separovic, M. Hanzevacki, D. Ljubanovic, B. Artukovic, M. Bratulic, M. Tisljar, B. Rekic, M. Gjurasin, P. Miklic, and G. Buljat Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats J. Physiol. (Paris) 91 1997 113 122 (Pubitemid 27467014)
47. G-nitro-l-arginine methylester and l-arginine effect on stomach mucosal integrity and blood pressure Eur. J. Pharmacol. 332 1997 23 33 (Pubitemid 27346600)
48. P. Sikiric, A. Marovic, W. Matoz, T. Anic, G. Buljat, D. Mikus, D. Stancic-Rokotov, J. Separovic, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, T. Ziger, B. Sebecic, I. Zoricic, B. Turkovic, G. Aralica, D. Perovic, B. Duplancic, M. Lovric-Bencic, I. Rotkvic, S. Mise, V. Jagic, and V. Hahn A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson's disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydrophyridine J. Physiol. (Paris) 93 1999 505 512 (Pubitemid 30038586)
49. P. Sikiric, S. Seiwerth, S. Deskovic, Z. Grabarevic, A. Marovic, R. Rucman, M. Petek, P. Konjevoda, S. Jadrijevic, T. Sosa, D. Perovic, G. Aralica, and B. Turkovic New model of cytoprotection/adaptive cytoprotection in rats: endogenous small irritants, antiulcer agents and indomethacin Eur. J. Pharmacol. 364 1999 23 31 (Pubitemid 29015783)
50. P. Sikiric, S. Seiwerth, S. Mise, M. Staresinic, V. Bedekovic, N. Zarkovic, S. Borovic, M. Gjurasin, A. Boban-Blagaic, L. Batelja, R. Rucman, and T. Anic Corticosteroids-impairment healing and gastric pentadecapeptide BPC 157 creams in burned mice Burns 29 2003 323 334 (Pubitemid 36627674)
51. P. Sikiric, S. Seiwerth, L. Brcic, A.B. Blagaic, I. Zoricic, M. Sever, R. Klicek, B. Radic, N. Keller, K. Sipos, A. Jakir, M. Udovicic, A. Tonkic, N. Kokic, B. Turkovic, S. Mise, and T. Anic Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, Pliva, Croatia). Full and distended stomach, and vascular response InflammoPharmacology 14 2006 1 8
52. S. Skorjanec, Z. Dolovski, I. Kocman, L. Brcic, A. Blagaic Boban, L. Batelja, M. Coric, M. Sever, R. Klicek, L. Berkopic, B. Radic, D. Drmic, D. Kolenc, S. Ilic, V. Cesarec, A. Tonkic, I. Zoricic, S. Mise, M. Staresinic, M. Ivica, M. Lovric Bencic, T. Anic, S. Seiwerth, and P. Sikiric Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole Dig. Dis. Sci. 54 2009 46 56
53. Q.A. Soltow, J.L. Betters, J.E. Sellman, V.A. Lira, J.H. Long, and D.S. Criswell Ibuprofen inhibits skeletal muscle hypertrophy in rats Med. Sci. Sports. Exerc. 38 2006 840 846
54. M. Staresinic, B. Sebecic, L. Patrlj, S. Jadrijevic, S. Suknaic, D. Perovic, G. Aralica, N. Zarkovic, S. Borovic, M. Srdjak, K. Hajdarevic, M. Kopljar, L. Batelja, A. Boban-Blagaic, I. Turcic, T. Anic, S. Seiwerth, and P. Sikiric Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth J. Orthopaed. Res. 21 2003 976 983 (Pubitemid 37322377)
55. M. Staresinic, I. Petrovic, T. Novinscak, I. Jukic, D. Pevec, S. Suknaic, N. Kokic, L. Batelja, L. Brcic, A. Boban-Blagaic, Z. Zoric, D. Ivanovic, M. Ajduk, B. Sebecic, L. Patrlj, T. Sosa, G. Buljat, T. Anic, S. Seiwerth, and P. Sikiric Effective therapy of transected quadriceps muscle in rat: gastric pentadecapeptide BPC 157 J. Orthopaed. Res. 24 2006 1109 1117 (Pubitemid 43804947)
56. S. Tanihara, Y. Hoshiyama, and T. Kawaguchi Sensitivity and specificity analysis of hepatic enzyme blood tests for the diagnosis of nonalcoholic fatty liver Fukuoka Daigaku igaku kiyō 34 2007 1 7
57. V.I. Tkalcevic, S. Cuzic, K. Brajsa, B. Mildner, A. Bokulic, K. Situm, D. Perovic, I. Glojnaric, and M.J. Parnham Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression Eur. J. Pharmacol. 570 2007 212 221 (Pubitemid 47247673)
58. Y. Tohyama, P. Sikirić, and M. Diksic Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-l- tryptophan autoradiographic measurements Life Sci. 76 2004 345 357 (Pubitemid 39452915)
59. B. Turkovic, P. Sikiric, S. Seiwerth, S. Mise, T. Anic, M. Petek, and R. Rucman Stable gastric pentadecapeptide BPC 157 studied for inflammatory bowel disease (PLD-116, PL14736, Pliva) induces nitric oxide synthesis Gastroenterology 126 2004 287
60. J.A. Vale, and T.J. Meredith Acute poisoning due to non-steroidal anti-inflammatory drugs clinical features and management Med. Toxicol. 1 1986 12 31 (Pubitemid 16024369)
61. M. Veljaca, C.A. Lesch, R. Pllana, B. Sanchez, K. Chan, and A. Guglietta BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats J. Pharmacol. Exp. Ther. 272 1994 417 422
62. M. Veljaca, K. Chan, and A. Guglietta Digestion of h-EGF, h-TGF alpha and BPC-15 in human gastric juice Gastroenterology 108 1995 A761
63. M. Veljaca, D. Pavic Sladoljev, B. Mildner, K. Brajsa, M. Bubenik, S. Stipanicic, and M.J. Parnham Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers (Suppl III) Gut 51 2003 A309
64. J.D. Wood The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904 Physiology 19 2004 326 330 (Pubitemid 39636079)
65. X.C. Xue, Y.J. Wu, M.T. Gao, W.G. Li, N. Zhao, Z.L. Wang, C.J. Bao, Z. Yan, and Y.Q. Zhang Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats World J. Gastroenterol. 10 2004 1032 1036 (Pubitemid 38461389)
66. X.C. Xue, Y.J. Wu, and M.T. Gao Study of the protective effects of pentadecapeptide BPC 157 on wounds in small type pigs Chin. New Drugs J. 12 2004 602 604