Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity

Digestive Diseases and Sciences

Volumn 41, Issue 8, 1996, Pages 1604-1614

  Sikirić, Predrag ^a   Seiwerth, Sven ^a   Grabarević, Željko ^a   Ručman, Rudolf ^a   Petek, Marijan ^a   Jagić, Vjekoslav ^a   Turković, Branko ^a   Rotkvić, Ivo ^a   Miše, Stjepan ^a   Zoričić, Ivan ^a   Gjurašin, Miroslav ^a   Konjevoda, Paško ^a   Šeparović, Jadranka ^a   Ljubanović, Danica ^a   Artuković, Branka ^a   Bratulić, Mirna ^a   Tišljar, Marina ^a   Jurina, Ljubica ^a   Buljat, Gojko ^a   Miklić, Pavao ^a   Marović, Anton ^a   more..

^a NONE

Author keywords

BPC 157; Capsaicin neurotoxicity; Gastric lesions; Gastroprotection; Neuroprotection; Organoprotective peptide; Pentadecapeptide; Rats

Indexed keywords

ALCOHOL; CAPSAICIN; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; INDOMETACIN; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SENSORY NERVE; STOMACH LESION; STOMACH PROTECTION; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 9444242743     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02087908     Document Type: Article

References (48)

1. Holzer P: Capsaicin: Cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev 43:143-201, 1991
2. Holzer P: Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev Physiol Biochem Pharmacol 121:49-146, 1991
3. Heiling M, Murison R: Intracerebroventricular neuropeptide Y protects against stress-induced gastric lesions in rat. Eur J Pharmacol 137:127-129, 1987
4. Hernandez DE: Neuroendocrine mechanisms of stress ulceration: Focus on thyrotropin-releasing hormone (TRH). Life Sci 39:279-296, 1986
5. Hernandez DE, Nemeroff CB, Orlando RO, Prange AJ: Influence of brain peptides on the development of stress gastric ulcers. In New Pharmacology of Ulcer Disease. Experimental and New Therapeutic Approaches. S Szabo, Gy Mózsik (eds). New York, Elsevier, 1987, pp 375-386
6. Takeuchi K, Johnson LR: Pentagastrin protects against stress ulceration in rats. Gastroenterology 76:788-792, 1979
7. Dodig M, Rotkvic I, Grabarevic Z, Sikiric P, Drahotusky T, Erceg D, Djacic S, Seiwerth S: Pentagastrin cytoprotection in ethanol-induced gastric mucosal lesions in rats. J Vet Med 40:509-515, 1993
8. Evangelista S, Maggi CA: Protection induced by cholecystokinin-8 (CCK-8) in ethanol-induced gastric lesions is mediated via vagal capsaicin-sensitive fibres and CCK-A receptors. Br J Pharmacol 102:119-122, 1991
9. Evangelista S, Renzi D, Guzzi P, Maggi CA: Decrease of gastric calcitonin gene-related peptide-like immunoreactivity is associated with ulcers induced by water-immersion stress in rats. Exp Clin Gastroenterol 1:51-53, 1991
10. Lippe IT, Lorbach M, Holzer P: Close arterial infusion of calcitonin gene-related peptide into the rat stomach inhibits aspirin- and ethanol-induced hemorrhage damage. Regul Pept 26:35-46, 1989
11. Sikiric P, Petek M, Rucman R, Rotkvic I, Seiwerth S, Grabarevic Z, Suchanek E, Jagic V, Krenjevic H, Mise S, Duvnjak M, Turkovic B, Udovicic I: Hypothesis: Stomach stress response, diagnostic and therapeutical value: A new approach in organo-protection. Exp Clin Gastroenterol 1:15-16, 1991
12. Sikiric P, Petek M, Rucman R, Rotkvic I, Seiwerth S, Grabarevic Z, Jagic V, Turkovic B, Mildner B, Duvnjak M, Cviko A, Kolega M, Dodig M, Sallmani A, Djacic S, Lucinger D, Erceg D: The significance of the gastroprotective effect of body protection compound (BPC): modulation by different procedures. In Cell Injury and Protection in the Gastrointestinal Tract: From Basic Sciences to Clinical Perspectives. Gy Mózsik, A Pár, G Csomós, M Kitajima, M Kondo, CJ Pfeiffer, KD Rainsford, P Sikiric, S Szabo (eds). Budapest, Akedémiai Kiadó, 1992, pp 89-98
13. Sikiric P, Petek M, Rucman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N: A new gastric juice peptide, BPC-an overview of stomach/stress/ organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87:313-327, 1993
14. 4 administration. A comparative study with dopamine agonists and somatostatin. Life Sci 53:PL291-PL296, 1993
15. Sikiric P, Gyires K, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Udovicic I, Jagic V, Mildner B, Duvnjak M, Danilovic Z: The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology 2:121-127, 1993
16. 2 receptor antagonists, dopamine promoters and gut peptides. Life Sci 54:PL63-PL68, 1944
17. Sikiric P, Rotkvic I, Mise S, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Zjacic-Rotkvic V, Duvnjak M, Jagic V, Suchanek E, Marovic A, Banic M, Brkic T, Hanzevacki M, Separovic J, Djacic S, Simicevic V: Dopamine agents efficacy in peptic ulcer healing and relapse prevention - a further indication for importance of stomach dopamine in the stress organoprotection concept. In Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Volume 2. S Szabo, Y Taché, G Glavin (eds). New York, Plenum Publishing, 1995, pp 221-230
18. Mózsik Gy, Sikiric P, Petek M: Gastric mucosal preventing body protective compound (BPC) effect on the development of ethanol and HCl-induced gastric mucosal injury. Exp Clin Gastroenterol 1:87-90, 1991
19. Paré W, Klucyznski JM: The effect of new gastric juice peptide BPC on classic stress triad in stress procedure. Exp Clin Gastroenterol 2:234-236, 1992
20. Veljaca M, Pllana R, Lesch CA, Sanchez B, Chan K, Guglietta A: Protective effect of BPC 157 on a rat model of colitis. Gastroenterology 106:789, 1994
21. Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272:417-422, 1994
22. Veljaca M, Lesch CA, Sanchez B, Low J, Guglietta A: Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action. Gastroenterology 108:936, 1995
23. Veljaca M, Chan K, Guglietta A: Digestion of h-EGF, h-TGF alpha, and BPC-15 in human gastric juice. Gastroenterology 108:761, 1995
24. Bosnjak ZJ, Graf BM, Sikiric P, Stowe DF: Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart. FASEB J 8:A129, 1994
25. Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228-236, 1985
26. Janesó G, Király E, Jancsó-Gabor A: Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741-743, 1977
27. Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761-767, 1979
28. Schmidt KL, Miller TA: Cytoprotection: Fact or fancy? The morphologic basis of gastric protection by prostaglandins. Exp Clin Gastroenterol 1:119-132, 1991
29. Sikiric P, Rotkvic I, Mise S, Krizanac S, Gjuris V, Jukic J, Suchanek E, Petek M, Udovicic I, Kalogjera L, Geber J, Tucan-Foretic M, Duvnjak M, Philipp M, Balen I, Anic T: The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats. Eur J Pharmacol 158:61-67, 1988
30. Paré W, Glavin G: Restraint stress in biomedical research: A review. Neurosci Biobehav 10:339-370, 1986
31. Sikiric P, Geber J, Ivanovic D, Suchanek E, Gjuris V, Tucan-Foretic M, Mise S, Cvitanovic B, Rotkvic I: Dopamine antagonists induce gastric lesions in rats. Eur J Pharmacol 131:105-109, 1986
32. Jancsó G, Király E: Sensory neurotoxins: Chemically induced selective destruction of primary sensory neurons. Brain Res 210:83-89, 1981
33. Jancsó G, Király E, Such G, Joó F, Nagy A: Neurotoxic effect of capsaicin in mammals. Acta Physiol Hung 69:295-313, 1987
34. Hottenstein OD, Pawlik WW, Remak G, Jacobson ED: Capsaicin-sensitive nerves modulate resting blood flow and vascular tone in rat gut. Naunyn Schmiedebergs Arch Pharmacol 343:179-184, 1991
35. Holzer P, Lippe IT, Amann R: Participation of capsaicin-sensitive afferent neurons in gastric motor inhibition caused by laparatomy and intraperitoneal acid. Neuroscience 48:715-722, 1992
36. Holzer P, Pabst MA, Lippe IT: Intragastrie capsaicin protects against aspirin-induced lesions formation and bleeding in the rat gastric mucosa. Gastroenterology 96:1425-1433, 1989
37. Szolcsányi J: Capsaicin type pungent agents producing pyrexia. In Pyretics and Antipyretics. Handbook of Experimental Pharmacology, Vol 60. AS Milton (ed). Berlin, Springer-Verlag, 1982, pp 437-478
38. Szolcśanyi J, Sann H, Pierau FK: Nociception in pigeons is not impaired by capsaicin. Pain 27:247-260, 1986
39. Watanabe T, Kawada T, Kurosawa M, Sato A, Iwai K: Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. Am J Physiol 255:E23-E27, 1988
40. Holzer P: Local effector functions of capsaicin-sensitive sensory nerve endings; involvement of tachykinins, calcitonin gene-related peptide and other neuropeptidces. Neuroscience 24:739-768, 1988
41. Lambrecht N, Buchert M, Respondek M, Müller KM, Peskar BM: Role of calcitonin gene related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 104:1371-1380, 1993
42. Thompson J, Greeley GH Jr, Rayford PL, Twonsed CM Jr: Gastrointestinal Endocrinology. New York, McGraw-Hill, 1987
43. Guglietta A: Possible clinical use of peptide growth factors in the GI tract: perspectives and obstacles. Exp Clin Gastroenterol 3:1-6, 1992
44. Maggi CA, Evangelista S, Giuliani S, Meli A. Anti-ulcer activity of calcitonin gene related peptide in rats. Gen Pharmacol 18:33-34, 1987
45. Whittle BJR, Lopez-Belmonte J, Moncada S: Regulation of gastric mucosal integrity by endogenous nitric oxide: Interaction with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99:607-611, 1990
46. Johnson G, Tsao P, Lefer AM. Synergism between superoxide dismutase and sodium nitrite in cardioprotection following ischemia and reperfusion. Am Heart J 119:530-537, 1990
47. Szabo S, Vatty P, Scarbrough E, Folkman J: Role of vascular factors, including angiogenesis, in the mechanisms of action of sucralfate. Am J Med 91(suppl 2a):158S-160S, 1991
48. Kalogjera L, Ries N, Baudoin T, Ferencic Z, Seiwerth S, Sikiric P: Dose dependent protective effect of BPC 157 in capasaicin induced rhinitis in rats. European Arch Otorhynolaringol 1996 (in press)