Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II: Comparison of NMR profiles classification of hepatotoxicity

Toxicological Sciences

Volumn 98, Issue 1, 2007, Pages 286-297

  Schoonen, Willem G E J ^a   Kloks, Cathelijne P A M ^a   Ploemen, Jan Peter H T M ^a   Smit, Martin J ^a   Zandberg, Pieter ^a   Horbach, G Jean ^a   Mellema, Jan Remt ^a   van Zuylen, Carol Thijssen ^a   Tas, Albert C ^b   van Nesselrooij, Joop H J ^b   Vogels, Jack T W E ^b  

^a NV ORGANON   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Cholestasis; Hepatotoxicity; Metabonomics; Necrosis; NMR; Steatosis; Urinalysis

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; BIOLOGICAL MARKER; BROMOBENZENE; CARBON TETRACHLORIDE; CHLORPROMAZINE; ETHINYLESTRADIOL; IBUPROFEN; IPRONIAZID; ISONIAZID; METHYLTESTOSTERONE; MIANSERIN; PARACETAMOL; PHENOBARBITAL; PLACEBO; TETRACYCLINE; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DRUG BLOOD LEVEL; DRUG URINE LEVEL; EARLY DIAGNOSIS; FATTY LIVER; HISTOPATHOLOGY; INTERMETHOD COMPARISON; INTRAHEPATIC CHOLESTASIS; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; PATTERN RECOGNITION; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS;

ANIMALS; BIOLOGICAL MARKERS; CHOLESTASIS; FATTY LIVER; HEPATITIS, TOXIC; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NECROSIS; PATTERN RECOGNITION, AUTOMATED; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; URINE;

ANIMALIA; RATTUS;

EID: 34447506508     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm077     Document Type: Article

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