Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression

European Journal of Pharmacology

Volumn 570, Issue 1-3, 2007, Pages 212-221

  Tkalčević, Vanesa Ivetić ^a   Čužić, Snježana ^a   Brajša, Karmen ^a   Mildner, Boris ^a   Bokulić, Ana ^a   Šitum, Kristina ^a   Perović, Daniela ^a   Glojnarić, Ines ^a   Parnham, Michael J ^a  

^a PLIVA Research Institute Ltd   (Croatia)

Author keywords

Collagen; egr 1 expression; Granulation tissue; PDGF BB; PL 14736; Wound healing

Indexed keywords

COLLAGEN; EARLY GROWTH RESPONSE FACTOR 1; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYL ASPARTYLALANYLGLYCYLLEUCYLVALINE; NERVE GROWTH FACTOR 1 A BINDING PROTEIN 2; PL 14736; PROTEIN; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; DRUG STABILITY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GRANULATION TISSUE; GRANULOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; WOUND; WOUND HEALING;

ANIMALS; CACO-2 CELLS; COLLAGEN; CYTOKINES; DIABETES MELLITUS; EARLY GROWTH RESPONSE PROTEIN 1; GRANULATION TISSUE; GRANULOMA, FOREIGN-BODY; HUMANS; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; PLATELET-DERIVED GROWTH FACTOR; PROTEINS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; WOUND HEALING;

EID: 34547837601     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.05.072     Document Type: Article

References (41)

1. Alexander D., Judex M., Meyringer R., Weis-Klemm M., Gay S., Mullwer-Ladner U., and Aicher W.K. Transcription factor Egr-1 activates collagen expression in immortalized fibroblasts of fibrosarcoma cells. Biol. Chem. 383 (2002) 1845-1853
2. Amendt C., Mann A., Schirmacher P., and Blessing M. Resistance of keratinocytes to TGFb-mediated growth restriction and apoptosis induction accelerates re-epithelization in skin wounds. J. Cell Sci. 115 (2002) 2189-2198
3. Basson M.D., Turowski G., and Emenaker N.J. Regulation of human (Caco-2) intestinal epithelial cell differentiation by extracellular matrix proteins. Exp. Cell. Res. 225 (1996) 301-305
4. Bilic M., Bumber Z., Boban Blagaic A., Batelja L., Seiwerth S., and Sikiric P. The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice. Burns 31 (2005) 310-315
5. Braddock M. The transcription factor Egr-1: a potential drug in wound healing and tissue repair. Ann. Med. 33 (2001) 313-318
6. Braddock M., Campbell C.J., and Zuder D. Current therapies for wound healing: electrical stimulation, biological therapeutics and the potential for gene therapy. Int. J. Dermatol. 38 (1999) 808-817
7. Bromann P.A., Korkaya H., Webb C.P., Miller J., Calvin T.L., and Courtneidge S.A. Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts. J. Biol. Chem. 280 (2005) 10253-10263
8. Bryant M., Drew G.M., Houston P., Hissey P., Campbell C.J., and Braddock M. Tissue repair with a therapeutic transcription factor. Hum. Gene Ther. 11 (2000) 2143-2158
9. Chan R.K., Liu P.H., Pietramaggiori G., Ibrahim S.I., Hechtman H.B., and Orgill D.P. Effect of recombinant platelet-derived growth factor (Regranex) on wound closure in genetically diabetic mice. J. Burn Care Res. 27 (2006) 202-205
10. Chen S.J., Yuan W., Mori Y., Levenson A., Trojanowska M., and Varga J. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. J. Invest. Dermatol. 112 (1999) 49-57
11. Cooper L., Johnson C., Burslem F., and Martin P. Wound healing and inflammation genes revealed by array analysis of "macrophageless" PU.1 null mice. Genome Biology 6 (2005) R5
12. Ghosh A.K., Yuan W., Mori Y., Chen S., and Varga J. Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β. J. Biol. Chem. 276 (2000) 11041-11048
13. Gillitzer R., and Goebeler M. Chemokines in cutaneous wound healing. J. Leukoc. Biol. 69 (2001) 513-521
14. Greenhalgh D.G., Sprugel K.H., Murray M.J., and Ross R. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am. J. Pathol. 136 (1990) 1235-1246
15. Greenhalgh D.G., Hummel R.P., Albertson S., and Breeden M.P. Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo. Wound Repair Regen. 1 (1993) 69-81
16. Ishida Y., Kondo T., Takayasu T., Iwakura Y., and Mukaida N. The essential involvement of cross-talk between IFN- γ and TGF-β in the skin wound-healing process. J. Immunol. 172 (2004) 1848-1855
17. Kamimura M., Bea F., Akizawa T., Katus H.A., Kreuzer J., and Viedt C. Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr-1. Hypertension 44 (2004) 944-951
18. Khachigian L.M. Early growth response-1 in cardiovascular pathobiology. Circ. Res. 98 (2006) 186-191
19. Kratchmarova I., Blagoev B., Haack-Sorensen M., Kassem M., and Mann M. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308 (2005) 1472-1477
20. Kumbrink J., Gerlinger M., and Johnson J.P. Egr-1 induces the expression of its corepressor Nab2 by activation of the Nab2 promoter thereby establishing a negative feedback loop. J. Biol. Chem. 280 (2005) 42785-42793
21. Laato M., Heino J., Gerdin B., Kähäri V.M., and Niinikoski J. Interferon-γ-induced inhibition of wound healing in vivo and in vitro. Ann. Chir. Gynaecol. 90 (2001) 19-23
22. LeGrand E.K. Preclinical promise of becaplermin (rhPDGF-BB) in wound healing. Am. J. Surg. 176 (1998) 48-54
23. LeGrand E.K., Senter L.H., Gamelli R.L., and Kiorpes T.C. Evaluation of PDGF-BB, PDGF-AA, bFGF, IL-1, and EGF dose responses in polyvinyl alcohol sponge implants assessed by a rapid histologic method. Growth Factors 8 (1993) 315-329
24. Lepistö J., Laato M., Niinikoski J., Lundberg C., Gerdin B., and Heldin C.H. Effects of homodimeric isoforms of platelet-derived growth factor (PDGF-AA and PDGF-BB) on wound healing in rat. J. Surg. Res 53 (1992) 596-601
25. Lepistö J., Peltonen J., Vähä-Kreula M., Söderström K.O., Niinikoski J., and Laato M. Selective modulation of collagen gene expression by different isoforms of platelet-derived growth factor in experimental wound healing. Cell Tissue Res. 286 (1996) 449-455
26. Lucerna M., Mechtcheriakova D., Kadl A., Schabbauer G., Schafer R., Gruber F., Koshelnick Y., Muller H.-D., Issbrucker K., Clauss M., Binder B.R., and Hofer E. NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J. Biol. Chem. 278 (2003) 11433-11440
27. Luna L.G. Histopathologic Methods and Color Atlas of Special Stains and Tissue Artifacts (1992), American Histolabs, Inc., Gaithersburg
28. Mulder G.D. Diabetic foot ulcers: old problems-new technology. Nephrol. Dial. Transplant. 16 (2001) 695-698
29. Reiber G.E., Lipsky B.A., and Gibbons G.W. The burden of diabetic foot ulcers. Am. J. Surg. 176 (1998) 5-10
30. Robson M.C. Wound infection: a failure of wound healing caused by an imbalance of bacteria. Surg. Clin. North Am. 77 (1997) 637-650
31. Senter L.H., Legrand E.K., Laemmerhirt K.E., and Kiorpes T.C. Assesment of full-thickness wounds in the genetically diabetic mouse for suitability as a wound healing model. Wound Repair Regen. 3 (1995) 351-358
32. Ševeljević-Jaran D., Čužić S., Dominis-Kramarić M., Glojnarić I., Ivetić V., Rado ević S., and Parnham M.J. Accelerated healing of excisional skin wounds by PL 14736 in alloxan hyperglycemic rats. Skin Pharmacol. Appl. Skin Physiol. 19 (2006) 266-274
33. Sikiric P., Petek M., Rucman R., Seiwerth S., Grabarevic Z., Rotkvic I., Jagic V., Turkovic B., Mildner B., Duvnjak M., and Lang N. A new gastric juice peptide, BPC-An overview of stomach/stress/organoprotection hypothesis and BPC beneficial effect. J. Physiol. 87 (1993) 313-327
34. Silverman E.S., and Collins T. Pathways of Egr-1 mediated gene transcription in vascular biology. Am. J. Pathol. 154 (1999) 665-670
35. Thyss R., Virolle V., Imbert V., Peyron J.-F., Aberdam D., and Virolle T. NF-kB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J. 24 (2005) 128-137
36. Tomasek J.J., Gabbiani G., Hinz B., Chaponnier C., and Brown R.A. Myofibroblasts and mechanoregulation of connective tissue remodeling. Nat. Rev., Mol. Cell Biol. 3 (2002) 349-363
37. Veljaca M., Lesch C.A., Pllana R., Sanchez B., Chan K., and Guglietta A. BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J. Pharmacol. Exp. Ther. 272 (1995) 417-422
38. Werner S., and Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83 (2003) 835-870
39. Woessner Jr. J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93 (1961) 440-447
40. Xue X.C., Wu Y.J., Gao M.T., Li W.G., Zhao N., Wang Z.L., Bao C.J., Yan Z., and Zhang Y.Q. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J. Gastroenterol. 10 (2004) 1032-1036
41. Yuan W., Yufit T., Li L., Mori Y., Chen S.J., and Varga J. Negative modulation of alpha1(I) procollagen gene expression in human skin fibroblasts: transcriptional inhibition by interferon-gamma. J. Cell Physiol. 179 (1999) 97-108