메뉴 건너뛰기




Volumn 24, Issue 3, 1999, Pages 195-202

Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: A comparison with bone marrow and autologous cortical bone implantation

Author keywords

Autologous cortical bone; Bone marrow; Gastric pentadecapeptide BPC 157; Implantation; Intramuscular application; Local application; Osteogenic effect; Rabbits; Segmental bone defects; Stomach

Indexed keywords

GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE;

EID: 0033105022     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(98)00180-X     Document Type: Article
Times cited : (60)

References (71)
  • 1
    • 0025053084 scopus 로고
    • The use of the Ilizarov concept with the AO/ASIF tubular fixateur in the treatment of segmental defects
    • Alonso J.E., Regazzoni P. The use of the Ilizarov concept with the AO/ASIF tubular fixateur in the treatment of segmental defects. Orthop Clinic North Am. 21:1990;655-665.
    • (1990) Orthop Clinic North Am , vol.21 , pp. 655-665
    • Alonso, J.E.1    Regazzoni, P.2
  • 2
    • 0024521423 scopus 로고
    • Osteogenic stem cells and stromal system of bone and marrow
    • Beresford J.N. Osteogenic stem cells and stromal system of bone and marrow. Clin Orthop. 240:1989;270-280.
    • (1989) Clin Orthop , vol.240 , pp. 270-280
    • Beresford, J.N.1
  • 3
    • 0000743581 scopus 로고
    • Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart
    • Bosnjak Z.J., Graf B.M., Sikiric P., Stowe D.F. Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart. FASEB J. 8:1994;A129.
    • (1994) FASEB J , vol.8
    • Bosnjak, Z.J.1    Graf, B.M.2    Sikiric, P.3    Stowe, D.F.4
  • 4
    • 0000875256 scopus 로고
    • The fate of bone grafts
    • A.G. Apley. London: Churchill
    • Burwell R.G. The fate of bone grafts. Apley A.G., Recent Advances in Orthopaedics. 1989;115-207 Churchill, London.
    • (1989) Recent Advances in Orthopaedics , pp. 115-207
    • Burwell, R.G.1
  • 5
    • 0025672641 scopus 로고
    • Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone
    • Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci. 87:1990;9843-9847.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 9843-9847
    • Celeste, A.J.1    Iannazzi, J.A.2    Taylor, R.C.3    Hewick, R.M.4    Rosen, V.5    Wang, E.A.6    Wozney, J.M.7
  • 6
    • 0024411572 scopus 로고
    • Development of an osteogenic bone-marrow preparation
    • Connolly J., Guse R., Lippiello L., Dehne R. Development of an osteogenic bone-marrow preparation. J Bone Jt Surg. 71-A:1989;684-691.
    • (1989) J Bone Jt Surg , vol.71 , pp. 684-691
    • Connolly, J.1    Guse, R.2    Lippiello, L.3    Dehne, R.4
  • 7
    • 0026356843 scopus 로고
    • Autologous marrow injection as a substitute for operative grafting of tibial nonunions
    • Connolly J.F., Guse R., Tiedeman J., Dehne R. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop. 266:1991;259-270.
    • (1991) Clin Orthop , vol.266 , pp. 259-270
    • Connolly, J.F.1    Guse, R.2    Tiedeman, J.3    Dehne, R.4
  • 8
    • 0028271621 scopus 로고
    • Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model
    • Cook S.D., Baffes G.C., Wolfe M.W., Sampath T.K., Rueger D.C. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop Rel Res. 301:1994;302-312.
    • (1994) Clin Orthop Rel Res , vol.301 , pp. 302-312
    • Cook, S.D.1    Baffes, G.C.2    Wolfe, M.W.3    Sampath, T.K.4    Rueger, D.C.5
  • 9
    • 0029018646 scopus 로고
    • Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates
    • Cook S.D., Wolfe M.W., Salkeld S.L., Rueger D.C. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Jt Surg. 77-A:1995;734-750.
    • (1995) J Bone Jt Surg , vol.77 , pp. 734-750
    • Cook, S.D.1    Wolfe, M.W.2    Salkeld, S.L.3    Rueger, D.C.4
  • 10
    • 0026594116 scopus 로고
    • Newest factors in fracture healing
    • Cornell C.N., Lane J.M. Newest factors in fracture healing. Clin Orthop. 277:1992;297-311.
    • (1992) Clin Orthop , vol.277 , pp. 297-311
    • Cornell, C.N.1    Lane, J.M.2
  • 11
    • 0019256650 scopus 로고
    • The regulation of haemopoiesis in long-term bone marrow cultures: Role of L-cell CSF
    • Dexter T., Shadduck R. The regulation of haemopoiesis in long-term bone marrow cultures Role of L-cell CSF . J Cell Phys. 102:1980;279-286.
    • (1980) J Cell Phys , vol.102 , pp. 279-286
    • Dexter, T.1    Shadduck, R.2
  • 12
    • 0028234082 scopus 로고
    • Biological principles of autogenous bone grafting
    • Eggers C., Meeder P.J. Biological principles of autogenous bone grafting. Injury. 25:(Suppl. 1):1994;17-20.
    • (1994) Injury , vol.25 , Issue.SUPPL. 1 , pp. 17-20
    • Eggers, C.1    Meeder, P.J.2
  • 13
    • 0029314291 scopus 로고
    • Enhancement of fracture-healing
    • Einhorn T.A. Enhancement of fracture-healing. J Bone Jt Surg. 77-A:1995;940-956.
    • (1995) J Bone Jt Surg , vol.77 , pp. 940-956
    • Einhorn, T.A.1
  • 14
    • 0018934268 scopus 로고
    • Autogenous cortical bone grafts in the construction of segmental skeletal defects
    • Ennecking W.F., Eady J.L., Burchardt H. Autogenous cortical bone grafts in the construction of segmental skeletal defects. J Bone Jt Surg. 62-A:1980;1039-1058.
    • (1980) J Bone Jt Surg , vol.62 , pp. 1039-1058
    • Ennecking, W.F.1    Eady, J.L.2    Burchardt, H.3
  • 15
    • 0017103248 scopus 로고
    • Precursor cells of mechanocytes
    • Friedenstein A.J. Precursor cells of mechanocytes. Int Rev Cytol. 47:1976;327-359.
    • (1976) Int Rev Cytol , vol.47 , pp. 327-359
    • Friedenstein, A.J.1
  • 16
    • 0024954184 scopus 로고
    • The biology of fracture healing: An overview for clinicians. Part I
    • Frost H.M. The biology of fracture healing An overview for clinicians. Part I . Clin Orthop. 248:1989;283-293.
    • (1989) Clin Orthop , vol.248 , pp. 283-293
    • Frost, H.M.1
  • 17
    • 0027753808 scopus 로고
    • Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture
    • Garg N.K., Gaur S., Sharma S. Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture. Acta Orthop Scand. 64:1993;671-672.
    • (1993) Acta Orthop Scand , vol.64 , pp. 671-672
    • Garg, N.K.1    Gaur, S.2    Sharma, S.3
  • 19
    • 0025260518 scopus 로고
    • Skeletal tissue response to cytokines
    • Goldring M.B., Goldring S.R. Skeletal tissue response to cytokines. Clin Orthop. 258:1990;245-278.
    • (1990) Clin Orthop , vol.258 , pp. 245-278
    • Goldring, M.B.1    Goldring, S.R.2
  • 20
    • 0026318653 scopus 로고
    • Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna
    • Grundel R.E., Chapman M.W., Yee T., Moore D.C. Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna. Clin Orthop. 266:1991;244-258.
    • (1991) Clin Orthop , vol.266 , pp. 244-258
    • Grundel, R.E.1    Chapman, M.W.2    Yee, T.3    Moore, D.C.4
  • 21
    • 0020964079 scopus 로고
    • Stress fracture of iliac bone with subfascial femoral neuropathy: Unusual complications at a bone graft donor site: Case report
    • Guha S.C., Poole M.D. Stress fracture of iliac bone with subfascial femoral neuropathy Unusual complications at a bone graft donor site: Case report . Br J Plast Surg. 36:1983;305-306.
    • (1983) Br J Plast Surg , vol.36 , pp. 305-306
    • Guha, S.C.1    Poole, M.D.2
  • 22
    • 0026578530 scopus 로고
    • Characterization of cells with osteogenic potential from human marrow
    • Haynesworth S.E., Goshima J., Goldberg V.M., Caplan A.I. Characterization of cells with osteogenic potential from human marrow. Bone. 13:1992;81-88.
    • (1992) Bone , vol.13 , pp. 81-88
    • Haynesworth, S.E.1    Goshima, J.2    Goldberg, V.M.3    Caplan, A.I.4
  • 23
    • 78651125117 scopus 로고
    • A comparative study of the healing process following different types of bone transplantation
    • Heiple K.G., Chase S.W., Herndon C.H. A comparative study of the healing process following different types of bone transplantation. J Bone Jt Surg. 45-A:1963;1593-1612.
    • (1963) J Bone Jt Surg , vol.45 , pp. 1593-1612
    • Heiple, K.G.1    Chase, S.W.2    Herndon, C.H.3
  • 24
    • 0024954722 scopus 로고
    • Current concepts of fracture healing
    • Hulth A. Current concepts of fracture healing. Clin Orthop. 249:1989;265-284.
    • (1989) Clin Orthop , vol.249 , pp. 265-284
    • Hulth, A.1
  • 25
    • 0024555042 scopus 로고
    • The tension-stress effect on the genesis and growth of tissues: Part I. The influence of stability of fixation and soft-tissue preservation
    • Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues Part I. The influence of stability of fixation and soft-tissue preservation . Clin Orthop. 238:1989;249-281.
    • (1989) Clin Orthop , vol.238 , pp. 249-281
    • Ilizarov, G.A.1
  • 26
    • 0024505048 scopus 로고
    • The tension-stress effect on the genesis and growth of tissues: Part II. The influence of rate and frequency of distraction
    • Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues Part II. The influence of rate and frequency of distraction . Clin Orthop. 239:1989;263-285.
    • (1989) Clin Orthop , vol.239 , pp. 263-285
    • Ilizarov, G.A.1
  • 27
    • 0025073322 scopus 로고
    • Clinical application of the tension-stress effect for limb lengthening
    • Ilizarov G.A. Clinical application of the tension-stress effect for limb lengthening. Clin Orthop. 250:1990;8-26.
    • (1990) Clin Orthop , vol.250 , pp. 8-26
    • Ilizarov, G.A.1
  • 30
    • 0028352787 scopus 로고
    • Calcium regulating hormones and bone mineral content in patients after subtotal gastrectomy
    • Kobayashi S., Takahashi C., Kuroda T., Sugenoya A., Iida F., Katoh K. Calcium regulating hormones and bone mineral content in patients after subtotal gastrectomy. Surg Today. 24:1994;295-298.
    • (1994) Surg Today , vol.24 , pp. 295-298
    • Kobayashi, S.1    Takahashi, C.2    Kuroda, T.3    Sugenoya, A.4    Iida, F.5    Katoh, K.6
  • 31
    • 0028033307 scopus 로고
    • Donor site morbidity at the iliac crest: Comparison of percutaneous and open methods
    • Kreibich D.N., Scott I.R., Wells J.M., Saleh M. Donor site morbidity at the iliac crest Comparison of percutaneous and open methods . J Bone Jt Surg. 76-B:1994;847-848.
    • (1994) J Bone Jt Surg , vol.76 , pp. 847-848
    • Kreibich, D.N.1    Scott, I.R.2    Wells, J.M.3    Saleh, M.4
  • 32
    • 0019958307 scopus 로고
    • Production of monocytes/macrophage colony stimulating factor by preadipocyte cell lines derived from murine marrow stroma
    • Lanoette M., Metcalf D., Dexter T. Production of monocytes/macrophage colony stimulating factor by preadipocyte cell lines derived from murine marrow stroma. J Cell Phys. 112:1982;123-127.
    • (1982) J Cell Phys , vol.112 , pp. 123-127
    • Lanoette, M.1    Metcalf, D.2    Dexter, T.3
  • 34
    • 0027416065 scopus 로고
    • Bone induction in monkeys by bone morphogenic protein: A tran-filter technique
    • Miyamoto S., Takaoka K., Ono K. Bone induction in monkeys by bone morphogenic protein A tran-filter technique . J Bone Jt Surg. 75-B:1993;107-110.
    • (1993) J Bone Jt Surg , vol.75 , pp. 107-110
    • Miyamoto, S.1    Takaoka, K.2    Ono, K.3
  • 35
    • 0013562396 scopus 로고
    • Pseudoarthroses
    • M.E. Muller, M. Algower, R. Schneider, & H. Willenegger. New York: Springer
    • Muller M.E. Pseudoarthroses. Muller M.E., Algower M., Schneider R., Willenegger H., Manuel of Internal Fixation, 2nd ed. 1977;335-355 Springer, New York.
    • (1977) Manuel of Internal Fixation, 2nd Ed , pp. 335-355
    • Muller, M.E.1
  • 36
    • 0022478005 scopus 로고
    • Percutaneous bone marrow grafting of fractures and bone defects: An experimental study in rabbits
    • Paley D., Young M.C., Wiley A.M., Fornasier V.L., Jackson R.W. Percutaneous bone marrow grafting of fractures and bone defects An experimental study in rabbits . Clin Orthop. 208:1986;300-312.
    • (1986) Clin Orthop , vol.208 , pp. 300-312
    • Paley, D.1    Young, M.C.2    Wiley, A.M.3    Fornasier, V.L.4    Jackson, R.W.5
  • 37
    • 0000986366 scopus 로고
    • The effect of new gastric juice peptide BPC on classic stress triad in stress procedure
    • Paré W., Klucyznski J.M. The effect of new gastric juice peptide BPC on classic stress triad in stress procedure. Exp Clin Gastroenterol. 4:1994;234-236.
    • (1994) Exp Clin Gastroenterol , vol.4 , pp. 234-236
    • Paré, W.1    Klucyznski, J.M.2
  • 38
    • 0015450378 scopus 로고
    • Biochemical studies on fracture healing in the rat with special reference to the oxygen supply
    • Penttinen R. Biochemical studies on fracture healing in the rat with special reference to the oxygen supply. Acta Chir Scand. 432:(Suppl.):1972;8-32.
    • (1972) Acta Chir Scand , vol.432 , Issue.SUPPL. , pp. 8-32
    • Penttinen, R.1
  • 39
    • 0014298648 scopus 로고
    • Hernia through an iliac bone-graft donor site a case report
    • Reid E.L. Hernia through an iliac bone-graft donor site a case report. J Bone Jt Surg. 50-A:1968;757-760.
    • (1968) J Bone Jt Surg , vol.50 , pp. 757-760
    • Reid, E.L.1
  • 40
    • 0023568307 scopus 로고
    • The molecular control of blood cell development
    • Sachs L. The molecular control of blood cell development. Science. 238:1987;1374-1379.
    • (1987) Science , vol.238 , pp. 1374-1379
    • Sachs, L.1
  • 41
    • 0001489142 scopus 로고    scopus 로고
    • The protective effect of a recently isolated gastric peptide in acute and chronic gastroduodenal injury
    • Sandor Z., Vincze A., Szabo S. The protective effect of a recently isolated gastric peptide in acute and chronic gastroduodenal injury. FASEB J. 10:1996;A171.
    • (1996) FASEB J , vol.10
    • Sandor, Z.1    Vincze, A.2    Szabo, S.3
  • 42
    • 0026083334 scopus 로고
    • Bone morphogenesis of rabbit bone morphogenetic protein-bound hydroxyapatite-fibrin composite
    • Sato T., Kawamura M., Sato K., Iwata H., Miura T. Bone morphogenesis of rabbit bone morphogenetic protein-bound hydroxyapatite-fibrin composite. Clin Orthop Rel Res. 263:1991;254-262.
    • (1991) Clin Orthop Rel Res , vol.263 , pp. 254-262
    • Sato, T.1    Kawamura, M.2    Sato, K.3    Iwata, H.4    Miura, T.5
  • 50
    • 0028002278 scopus 로고
    • The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and dudodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats: A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides
    • Sikiric P., Seiwerth S., Grabarevic Z., Petek M., Rucman R., Turkovic B., Rotkvic I., Jagic V., Duvnjak M., Mise S., Djacic S., Separovic J., Veljaca M., Sallmani A., Banic M., Brkic T. The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and dudodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides . Life Sci. 54:1994;63-68.
    • (1994) Life Sci , vol.54 , pp. 63-68
    • Sikiric, P.1    Seiwerth, S.2    Grabarevic, Z.3    Petek, M.4    Rucman, R.5    Turkovic, B.6    Rotkvic, I.7    Jagic, V.8    Duvnjak, M.9    Mise, S.10    Djacic, S.11    Separovic, J.12    Veljaca, M.13    Sallmani, A.14    Banic, M.15    Brkic, T.16
  • 56
    • 0028236614 scopus 로고
    • Applications and techniques of vascularized bone transfer
    • Stock W., Hierner R. Applications and techniques of vascularized bone transfer. Injury. 25:(Suppl. 1):1994;35-45.
    • (1994) Injury , vol.25 , Issue.SUPPL. 1 , pp. 35-45
    • Stock, W.1    Hierner, R.2
  • 57
    • 0024362147 scopus 로고
    • Donor site pain from the ilium: A complication of lumbar spine fusion
    • Summers B.N., Eisenstein S.M. Donor site pain from the ilium A complication of lumbar spine fusion . J Bone Jt Surg. 71-B:1989;677-680.
    • (1989) J Bone Jt Surg , vol.71 , pp. 677-680
    • Summers, B.N.1    Eisenstein, S.M.2
  • 58
    • 0026471229 scopus 로고
    • Do different fluorochrome labels give equivalent histomorphometric information?
    • Sun T.C., Mori S., Roper J., Brown C., Hooser T., Burr D.B. Do different fluorochrome labels give equivalent histomorphometric information? Bone. 13:1992;443-446.
    • (1992) Bone , vol.13 , pp. 443-446
    • Sun, T.C.1    Mori, S.2    Roper, J.3    Brown, C.4    Hooser, T.5    Burr, D.B.6
  • 60
    • 0026351805 scopus 로고
    • Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix: An experimental study in dogs
    • Tiedeman J.J., Connolly J.F., Strates B.S., Lippiello L. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix An experimental study in dogs . Clin Orthop. 268:1991;294-302.
    • (1991) Clin Orthop , vol.268 , pp. 294-302
    • Tiedeman, J.J.1    Connolly, J.F.2    Strates, B.S.3    Lippiello, L.4
  • 61
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist M.R. Bone Formation by autoinduction . Science. 150:1965;893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 62
    • 0001449699 scopus 로고
    • Solubilized and insolubilized bone morphogenetic protein
    • Urist M.R., Mikulski A., Lietze A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci. 76:1979;1828-1832.
    • (1979) Proc Natl Acad Sci , vol.76 , pp. 1828-1832
    • Urist, M.R.1    Mikulski, A.2    Lietze, A.3
  • 63
    • 0000548565 scopus 로고
    • Digestion of h-EGF, h-TGF alpha, and BPC-15 in human gastric juice
    • Veljaca M., Chan K., Guglietta A. Digestion of h-EGF, h-TGF alpha, and BPC-15 in human gastric juice. Gastroenterology. 108:1995;761.
    • (1995) Gastroenterology , vol.108 , pp. 761
    • Veljaca, M.1    Chan, K.2    Guglietta, A.3
  • 66
    • 0000377179 scopus 로고
    • Protection of BPC-15 on TNBS-induced colitis in rats: Possible mechanisms of action
    • Veljaca M., Lesch C.A., Sanchez B., Low J., Guglietta A. Protection of BPC-15 on TNBS-induced colitis in rats Possible mechanisms of action . Gastroenterology. 108:1995;936.
    • (1995) Gastroenterology , vol.108 , pp. 936
    • Veljaca, M.1    Lesch, C.A.2    Sanchez, B.3    Low, J.4    Guglietta, A.5
  • 68
    • 0017689426 scopus 로고
    • Meralgia paresthetica: A complication of iliac bone procurement
    • Weikel A.M., Habal M.B. Meralgia paresthetica A complication of iliac bone procurement . Plast Reconstr Surg. 60:1977;572-574.
    • (1977) Plast Reconstr Surg , vol.60 , pp. 572-574
    • Weikel, A.M.1    Habal, M.B.2
  • 70
    • 0028902222 scopus 로고
    • Postgastrectomy osteomalacia with pseudofractures assessed by repeated bone scintigraphy
    • Wu Y.W., Seto H., Shimizu M., Kageyama M., Watanabe N., Kakishita M. Postgastrectomy osteomalacia with pseudofractures assessed by repeated bone scintigraphy. Ann Nucl Med. 9:1995;29-32.
    • (1995) Ann Nucl Med , vol.9 , pp. 29-32
    • Wu, Y.W.1    Seto, H.2    Shimizu, M.3    Kageyama, M.4    Watanabe, N.5    Kakishita, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.