Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats

European Journal of Pharmacology

Volumn 667, Issue 1-3, 2011, Pages 410-418

  Balamurugan, Rangachari ^a   Duraipandiyan, Veeramuthu ^a   Ignacimuthu, Savarimuthu ^a  

^a LOYOLA COLLEGE   (India)

Author keywords

Sitosterol; Antidiabetic; Hepatic marker enzyme; Insulin; Lippia nodiflora; Streptozotocin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CLIONASTEROL; GLIBENCLAMIDE; GLUCOSE; GLYCOGEN; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPPIA NODIFLORA EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPPIA; LIPPIA NODIFLORA; LIVER INJURY; LIVER PROTECTION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT GAIN;

ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY WEIGHT; CARBOHYDRATE METABOLISM; DIABETES MELLITUS, EXPERIMENTAL; FASTING; GLYCOGEN; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INSULIN; LIPID METABOLISM; LIPPIA; LIVER; MALE; MUSCLES; RATS; RATS, WISTAR; SITOSTEROLS;

EID: 80052023878     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.025     Document Type: Article

References (58)

1. E.A. Abdel-Rahim, S.S. El-Saadany, A.M. Abo-Eytta, and M.M. Wasif The effect of Sammo administration on some fundamental enzymes of pentose phosphate pathway and energy metabolites of alloxanized rats Nahrung 36 1992 8 14
2. K.G.M.M. Alberti, and C.M. Press H. Keen, J. Jarret, The Biochemistry of the Complications of Diabetes Mellitus 1982 Publishers Edware Arnold Ltd London 231 270
3. L. Al-Shamaony, S.M. Al-Khazraji, and H.A. Twaij Hypoglycemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. J. Ethnopharmacol. 43 1994 167 171 (Pubitemid 24232182)
4. D.M.O. Aragao, L. Guarize, J. Lanini, J.C. Da Costa, R.M.G. Garcia, and E. Scio Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats J. Ethnopharmacol. 128 2010 629 633
5. M.J. Aybar, A.N. Sanchez Riera, A. Grau, and S.S. Sanchez Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats J. Ethnopharmacol. 74 2001 125 132 (Pubitemid 32141094)
6. C.J. Bailey Potential new treatments for type 2 diabetes Trends. Pharmacol. Sci. 21 2000 259 265 (Pubitemid 30445253)
7. R. Balamurugan, P. Pandikumar, and S. Ignacimuthu Hypoglycemic effect of Lippia nodiflora (L.) in streptozotocin induced diabetic rats. Supplement to the fourth current trends in drug discovery research Med. Chem. Res 19 2010 S1 S145 ISSN 1054-2523
8. H.U. Bergmeyer H.U. Bergmeyer, Glucose-6-phosphate Dehydrogenase Methods of Enzymatic Analysis Vol. 2 1984 Verlag Chemie Weinheim, Germany 222 223
9. M.M. Best, C.H. Duncan, E.J. Van loon, and J.D. Wathen Lowering of serum cholesterol by the administration of a plant sterol Circulation 10 1954 201 206
10. N.V. Carrol, R.W. Longley, and J.H. Roe The determination of glycogen in liver and muscle by use of anthrone reagent J. Biol. Chem. 220 1956 543 583
11. V. Chen, and C.D. Ianuzzo Dosage effect of streptozotocin on rat tissue enzyme activities and glycogen concentration Can. J. Physiol. Pharmacol. 60 1982 1251 1256 (Pubitemid 13218548)
12. R. Chen, M. Meseck, R.C. McEvoy, and S.L.C. Woo Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells Gene. Ther. 7 2000 1802 1809
13. M. Concepcion Navarro, M. Pilar Montilla, A. Martin, J. Jimenez, and M. Pilar Utrilla Free radical scavenger and antihepatotoxic activity of Rosmarinus tomentosus Plant. Med. 59 1993 312 314 (Pubitemid 23238217)
14. K. Dickinson, T.J. North, S. Sills, D.M. Anthony, J.I. Lock, D.T. Vowles, and R.B. Jones BTS 67 582 stimulates insulin secretion from perifused rat pancreatic islets Eur. J. Pharmacol. 339 1997 69 76 (Pubitemid 28015433)
15. A. Durairaj, T.S. Vaiyapuri, M.U. Kanti, and G. Malaya Protective activity and antioxidant potential of Lippia nodiflora extract in paracetamol induced hepatotoxicity in rats Iran. J. Pharmacol. Ther. 7 2008 83 89
16. A.M. Forestieri, M.T. Monforte, S. Ragusa, A. Trovato, and L. Iauk Anti-inflammatory, analgesic and antipyretic activity in rodents of plant extracts used in African medicine Phytother. Res. 10 1996 100 106 (Pubitemid 26106055)
17. W.T. Friedewald, R.T. Levy, and D.S. Frederickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultra centrifuge Clin. Chem. 18 1972 499 502
18. K.H. Gabbay Glycosylated haemoglobin and diabetic control N. Engl. J. Med. 295 1976 443 444
19. S. Golden, P.A. Wals, F. Okajima, and J. Katz Glycogen synthesis by hepatocytes from diabetic rats Biochem. J. 182 1979 727 734 (Pubitemid 10243677)
20. A. Gomes, J.R. Vedasiromoni, M. Das, R.M. Sharma, and D.K. Ganguly Antihyperglycemic effect of black tea (Camellia sinensis) in rat J. Ethnopharmacol. 45 2001 223 226
21. J.K. Grover, V. Vats, and S.S. Rathi Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism J. Ethnopharmacol. 73 2000 461 470
22. R. Gupta, A.K. Sharma, M.P. Dobhal, M.C. Sharma, and R.S. Gupta Antidiabetic and antioxidant potential of β-sitosterol in Streptozotocin-induced experimental hyperglycemia J. Diabetes 3 2011 29 37
23. Z. Hassan, M.F. Yam, M. Ahmad, and A.P. Yusof Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin- induced diabetic rats Molecules 15 2010 9008 9023
24. 2+/calmodulin and cyclic 3,5′ adinosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic β-cell Endocrinology 137 1996 4644 4649 (Pubitemid 26403300)
25. S.M. Hsu, L. Raine, and H. Fanger Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures J. Histochem. Cytochem. 29 1981 577 580 (Pubitemid 11147380)
26. S.L. Hwang, H.N. Kim, H.H. Jung, J.E. Kim, D.K. Choi, J.M. Hur, J.Y. Lee, H. Song, K.S. Song, and T.L. Huh Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase Biochem. Biophys. Res. Commun. 377 2008 1253 1258
27. P.S. Jain, S.B. Bari, and S.J. Surana Isolation of stigmasterol and γ-sitosterol from petroleum ether extract of woody stem of Abelmoschus manihot Asian. J. Biol. Sci 2 2009 112 117
28. A. Junod, A.E. Lambert, W. Stauffacher, and A.E. Renold Diabetogenic action of streptozotocin: relationship of dose to metabolic response J. Clin. Invest. 48 1969 2129 2139
29. H. Khalil, H. Ismail, A. Taye, and M. Kamel Gastroprotective effect of Lippia nodiflora L. extracts in ethanol induced gastric lesions Phcog. Mag 3 2007 259 262
30. B.A. Khan, A. Abraham, and S. Leelamma Hypoglycemic action of Murraya koenigii (curry leaf), Brassica juncea (mustard); mechanism of action Ind. J. Biochem. Biophys. 32 1995 106 108
31. J. King Determination of serum alkaline and acid phosphatase Practical Clinical Enzymology 1959 Van Nostrand London, UK
32. R.J. Koeing, C.M. Peterson, R.L. Jones, C. Saudek, M. Lehrman, and A. Cerami Correlation of glucose regulation and haemoglobin AIc in diabetes mellitus N. Engl. J. Med. 295 1976 417 420
33. H. Koide, and T. Oda Pathological occurrence of glucose 6-phosphatase in serum in liver diseases Clin. Chim. Acta 4 1959 554 561
34. 2+ independent pathways in stimulus coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements; studies on rat pancreatic islets Endocrinology 139 1998 1172 1183 (Pubitemid 28510137)
35. W.L. Li, H.C. Zheng, J. Bukuru, and N. De Kimpe Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus J. Ethnopharmacol. 92 2004 1 21 (Pubitemid 38510258)
36. K.P. Manoharan, T.K. Benny, and D. Yang Cycloartane type triterpenoids from the rhizomes of Polygonum bistorta Phytochemistry 66 2005 2304 2308 (Pubitemid 41405813)
37. R.J. Marles, and N.R. Farnsworth Antidiabetic plants and their active constituents Phytomedicine 2 1995 137 189
38. S.K. Mitra, S. Gopumadhavan, T.S. Muralidhar, S.D. Anturlikar, and M.B. Sujatha Effect of D-400, a herbomineral preparation on lipid profile, glycated hemoglobin and glucose tolerance in streptozotocin induced diabetes in rats Ind. J. Exp. Biol. 33 1995 798 800
39. S. Moskalewski Isolation and culture of islets of Langerhans of guinea pig Gen. Comp. Endocrinol. 5 1965 342 353
40. T. Mukherjee Antimalarial herbal drugs. A review Fitoterapia 62 1991 197 204
41. Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W., 2000. Harper' Biochemistry, twenty fifth ed. Appleton and Lange, Stanford, C.T.
42. K. Nagy, B. Kis, N.C. Rajapakse, F. Bari, and D.W. Busija Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation J. Neurosci. Res. 75 2004 697 704 (Pubitemid 38691792)
43. S.S. Nayak, and T.N. Pattabiraman A new colorimetric method for the estimation of glycosylated haemoglobin Clin. Chim. Acta 109 1981 267 274 (Pubitemid 11165574)
44. P. Nicasio, L. Aguilar-Santamaria, E. Aranda, S. Ortiz, and M. Gonzalez Hypoglycemic effect and chlorogenic acid content in two Cecropia species Phytother. Res. 19 2005 661 664 (Pubitemid 41433627)
45. E.A. Nikkila, and M. Kekki Plasma transport kinetics in diabetes mellitus Metabolis. 22 1973 1 22
46. O.C. Ohaeri Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats Biosci. Rep. 21 2001 19 24 (Pubitemid 32703509)
47. T. Ohta, N. Furukawa, G. Komuro, F. Yomemori, and K. Wakitani JTT-608 restores impaired early insulin secretion in diabetic Gotokakizaki rats Brit. J. Pharmacol. 126 1999 1674 1680 (Pubitemid 29182354)
48. M.E. Pacual, K. Slowing, E. Carretero, D. Sanchez Mata, and A. Villar Lippia: traditional uses, chemistry and pharmacology: A review J. Ethnopharmacol. 76 2001 201 214 (Pubitemid 32640159)
49. H.P. Rang, and M.M. Dale The Endocrine System Pharmacology second ed 1991 Longman Group Ltd United Kingdom 504 508
50. S. Reitman, and S. Frankel A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases Am. J. Clin. Pathol. 28 1957 56 63
51. W. Stalmans, J. Cadefau, S. Wera, and M. Bollen New insight into the regulation of liver glycogen metabolism by glucose Biochem. Soc. Trans. 25 1997 19 25 (Pubitemid 27092541)
52. T. Szkudelski, and K. Szkudeslka Streptozotocin induces lypolysis in rat adipocytes in vitro Physiology Resh. 51 2002 255 259 (Pubitemid 34970179)
53. F.C. Terblanche, and G. Kornelius Essential oil constituents of the genus Lippia (Verbenaceae)-A literature review J. Essent. Oil. Res. 8 1996 471 485 (Pubitemid 126479282)
54. F.A. Tomas-Barberan, J.B. Harborne, and R. Self Twelve 6-oxygenated flavone sulphates from Lippia nodiflora and L. canescens Phytochemistry 26 1987 2281 2284
55. P. Triender Determination of glucose using glucose oxidase with an alternative oxygen acceptor Annu. Clin. Biochem. 6 1969 24 27
56. N.H. Ugochukwu, and N.E. Babady Antioxidant effects of Gongronema latifolium in hepatocytes of rat models of non-insulin dependent diabetes mellitus Fitoterapia 73 2002 612 618 (Pubitemid 35477757)
57. J. Welihinda, and E.H. Karuanayake Extra pancreatic effect of Momordica charantia in rats J. Ethnopharmacol. 17 1986 247 255
58. N.F. Wiernsperger, and C.J. Bailey The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms Drugs 58 1999 31 39 (Pubitemid 129758579)