Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats

Journal of Ethnopharmacology

Volumn 128, Issue 3, 2010, Pages 629-633

  Aragão, Danielle M O ^a   Guarize, Lyvia ^a   Lanini, Juliana ^a   da Costa, Juliana C ^a   Garcia, Raúl M G ^a   Scio, Elita ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Antioxidant; Cecropia pachystachya; Cecropiaceae; Diabetes; Hypoglycemic

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALLOXAN; ALUMINUM CHLORIDE; ASCORBIC ACID; CECROPIA PACHYSTACHYA EXTRACT; CHLOROGENIC ACID; EMBRAFARMA; FLAVONE DERIVATIVE; FLAVONOID; GLIBENCLAMIDE; GLUCOSE; ISOORIENTIN; LEAD SULFIDE; METFORMIN; METHANOL; ORIENTIN; PHENOL DERIVATIVE; PLANT EXTRACT; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CECROPIA; CECROPIA PACHYSTACHYA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DETERMINATION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT LEAF; QUALITATIVE ANALYSIS; RAT;

ALLOXAN; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD GLUCOSE; CECROPIA PLANT; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; FLAVONOIDS; FREE RADICAL SCAVENGERS; GLUCOSE TOLERANCE TEST; GLUCOSIDES; GLYBURIDE; HYPOGLYCEMIC AGENTS; MALE; MEDICINE, TRADITIONAL; METFORMIN; PHENOLS; PLANT EXTRACTS; RATS; RATS, WISTAR;

CECROPIA PACHYSTACHYA; RATTUS; URTICACEAE;

EID: 77951208800     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.01.008     Document Type: Article

References (35)

1. Almeida E.R., Guedes M.C., Albuquerque J.F.C., Xavier H. Hypoglycemic effect of Bauhinia Cheilandra in rats. Fitoterapia 2006, 77:276-278.
2. Andrade-Cetto A., Wiedenfeld H. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. Journal of Ethnopharmacology 2001, 78:145-149.
3. Andrade-Cetto A., Heinrich M. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. Journal of Ethnopharmacology 2005, 99:325-348.
4. Chaillou L.L., Nazareno M.A. New method to determine antioxidant activity of polyphenols. Journal of Agricultural and Food Chemistry 2006, 54:8397-8402.
5. Consolini A.E., Migliori G.N. Cardiovascular effects of the South American medicinal plant Cecropia pachystachya (ambay) on rats. Journal of Ethnopharmacology 2005, 96:417-422.
6. Consolini A.E., Ragone M.I., Migliori G.N., Conforti P., Volonte M.G. Cardiotonic and sedative effects of Cecropia pachystachya Mart. (ambay) on isolated rat hearts and conscious mice. Journal of Ethnopharmacology 2006, 106:90-96.
7. Duh P.D., Yen G.C. Antioxidative activity of three herbal water extracts. Food Chemistry 1997, 60:639-645.
8. Fisher J. Drugs and chemicals that produce diabetes. Trends in Pharmacological Sciences 1985, 6:72-75.
9. Govidarajan R., Rastogi S., Vijayakumar M., Shirwaikar A., Rawat A.K.S., Mehrotra S., Pushpangadan P. Studies on the antioxidant activities of Desmodium gangeticum. Biological & Pharmaceutical Bulletin 2003, 26:1424-1427.
10. Gupta M.P., Solis N.G., Avella M.E., Sanchez C. Hypoglycemic activity of Neurolena lobata. Journal of Ethnopharmacology 1984, 10:323-327.
11. Harborne J.B. Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis 1998, Chapman & Hall, London. 3rd ed.
12. Hikawczuk V.J., Saad J.R., Guardia T., Juarez A.O., Giordano O.S. Anti-inflammatory activity of compounds isolated from Cecropia packystachya. Anales de la Associación Química Argentina 1998, 86:167-170.
13. Ivorra M.D., Paya M., Villar A. A review of natural products and plants as potent antidiabetic drugs. Journal of Ethnopharmacology 1989, 27:243-275.
14. Kanatt S.R., Chandder R., Sharma A. Antioxidant potential of mint (Mentha spicata L.) in radiation-processed lamb meat. Food Chemistry 2007, 100:451-458.
15. Letitia M., Cune Mc., Timothy T. Antioxidant activity in medicinal plant associated with the symptoms of diabetes mellitus used by the Indigenous peoples of the North American boreal forest. Journal of Ethnopharmacology 2002, 82:197-205.
16. Lorenzi, H., Matos, F.J.A., 2002. Plantas medicinais do Brasil, 1st ed. Nova Odessa. Instituto Plantarum, São Paulo.
17. Mabry T.J., Markham K.R., Thomas M.B. The Systematic Identification of Flavonoids 1970, Springer-Verlag, Heidelberg/New York.
18. Machado E.C., Yunes R.A., Malheiros A., Gomez E.C., Delle Monache F. Two new 11α,12α-epoxy-ursan-28,13β-olides and other triterpenes from Cecropia catharinensis. Natural Product Research 2008, 22:1310-1316.
19. Mier S., Kaner I., Akiri B., Hadas S.P. Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. Journal of Agricultural and Food Chemistry 1995, 43:1813-1817.
20. Miliauskas G., Venskutonis P.R., Van Beek T.A. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chemistry 2004, 85:231-237.
21. Nicasio P., Aguilar-Santamaría L., Aranda E., Ortiz S., González M. Hypoglycemic effect and chlorogenic acid content in two Cecropia species. Phytotherapy Research 2005, 19:661-664.
22. Nicasio-Torres M.P., Erazo-Gómez J.C., Cruz-Sosa F. In vitro propagation of two antidiabetic species known as guarumbo: Cecropia obtusifolia and Cecropia peltata. Acta Physiologiae Plantarum 2009, 31:905-914.
23. Okuda T. Systematics and health effects of chemically distinct tannins in medicinal plants. Phytochemistry 2005, 66:2012-2031.
24. Oyaku M. Studies on product of browning reaction prepared from glucose amine. Japanese Journal of Nutrition 1986, 44:307-315.
25. Schwab D., Herling A.W., Hemmerle H., Schubert G., Hagenbuch B., Burger H.J. Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins. The Journal of Pharmacology and Experimental Therapeutics 2001, 296:91-98.
26. Sociedade Brasileira de Diabetes (SBD), 2009. Diabetes hoje. Available at (accessed 16.12.09). http://www.diabetes.org.br/colunistas-da-sbd/diabetes-hoje/.
27. Soraru S.B., Bandoni A.L. Plantas de la medicina popular Argentina 1978, Albatros, Buenos Aires.
28. Sy G.Y., Cissé A., Nongonierma R.B., Sarr M., Mbodj N.A., Faye B. Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats. Journal of Ethnopharmacology 2005, 98:171-175.
29. Tanae M.M., Lima-Landman M.T.R., De Lima T.C.M., Souccar C., Lapa A.J. Chemical standardization of he aqueous extract of Cecropia glaziovii Sneth endowed with antihypertensive, bronchodilator, antiacid secretion and antidepressant-like activities. Phytomedicine 2007, 14:309-317.
30. Twaij H.A.A.A., Al-Badr A.A. Hypoglycemic activity of Artemisia herba Alba. Journal of Ethnopharmacology 1998, 24:123-126.
31. Valiathan M.S. Healing plants. Current Science 1998, 75:1122-1127.
32. Vila F.C., Colombo R., de Lira T.O., Yariwake J.H. HPLC microfractionation of flavones and antioxidant (radical scavenging) activity of Saccharum officinarum L. Journal of the Brazilian Chemical Society 2008, 19:903-908.
33. Wong C.C., Li H.B., Cheng K.W., Chen F. A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay. Food Chemistry 2006, 97:705-711.
34. World Health and Organization. Prevalence data of diabetes worldwide. Available at (accessed 16.12.09). http://www.who.int/mediacentre/factsheets/fs312/en/index.html.
35. Zhang Y., Bao B., Lu B., Ren Y., Tie X., Zhang Y. Determination of flavone C-glucosides in antioxidant of bamboo leaves (AOB) fortified foods by reversed-phase high-performance liquid chromatography with ultraviolet diode array detection. Journal of Chromatography A 2005, 1065:177-185.