Beneficial effects of β-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase

Biochemical and Biophysical Research Communications

Volumn 377, Issue 4, 2008, Pages 1253-1258

  Hwang, Seung Lark ^a   Kim, Ha Na ^a   Jung, Hyun Hee ^a   Kim, Ji Eun ^a   Choi, Dong Kyu ^a   Hur, Jong Moon ^a   Lee, Jai Youl ^a   Song, Hebok ^a   Song, Kyung Sik ^a   Huh, Tae Lin ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Sitosterol; AMP activated protein kinase (AMPK); Cholesterol; Glucose uptake; Schizonepeta tenuifolia; Triglycerides

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; RADICICOL; SITOSTEROL; TRIACYLGLYCEROL;

ALPHA CHAIN; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HELA CELL; HUMAN; HUMAN CELL; LIPID METABOLISM; MOLECULAR MECHANICS; MYOTUBE; PRIORITY JOURNAL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTILIPEMIC AGENTS; CELL LINE; CHOLESTEROL; ENZYME ACTIVATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; LIPID METABOLISM; MUSCLE FIBERS, SKELETAL; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RATS; SIGNAL TRANSDUCTION; SITOSTEROLS; TRIGLYCERIDES;

SCHIZONEPETA TENUIFOLIA;

EID: 56349118899     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.136     Document Type: Article

References (35)

1. Miettinen T.A., Puska P., Gylling H., Vaniianen H., and Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N. Engl. J. Med. 16 (1995) 1308-1312
2. Ostlund Jr. R.E. Phytosterols in human nutrition. Annu. Rev. Nutr. 22 (2002) 533-549
3. Pouteau E.B., Monnard I.E., Piguet-Welsch C., Groux M.J., Sagalowicz L., and Berger A. Non-esterified plant sterols solubilized in low-fat milks inhibit cholesterol absorption. Eur. J. Nutr. 42 (2003) 154-164
4. Bouic P.J. Sterols and sterolins: new drugs for the immune system?. Drug Discov. Today 7 (2002) 775-778
5. Bouric P.J., and Lamprecht J.H. Plant sterols and sterolins: a review of their immune-modulating properties. Altern. Med. Rev. 4 (1999) 170-177
6. Awad A.B., and Fink C.S. Phytoserols as anticancer dietary components: evidence and mechanism of action. J. Nutr. 130 (2000) 2127-2130
7. Sutherland W.H., Scott R.S., Lintott C.J., Robertson M.C., Stapely S.A., and Cox C. Non-cholesterol sterols in patients with non-insulin dependent mellitus. Horm. Metab. Res. 24 (1992) 172-175
8. Hardie D.G., Scott J.W., Pan D.A., and Hudson E.R. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546 (2003) 113-120
9. Carling D. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci. 29 (2004) 18-24
10. Weekes J., Hawley S.A., Corton J., Shugar D., and Hardie D.G. Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP, AMP analogues. Eur. J. Biochem. 219 (1994) 751-757
11. Kurth-Kraczek E.J., Hirshman M.F., Goodyear L.J., and Winder W.W. 5-AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48 (1999) 1667-1671
12. Hardie D.G., and Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioassays 23 (2001) 1112-1119
13. Carling D., Zammit V.A., and Hardie D.G. A common bicyclic protein kinase cascade inactivates the regulatory enzyme of fatty acid and cholesterol biosynthesis. FEBS Lett. 223 (1987) 217-222
14. Drynan L., Quant P.A., and Zammit V.A. Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states. Biochem. J. 317 (1996) 791-795
15. Merrill G.F., Kurth E.J., Hardie D.G., and Winder W.W. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273 (1997) E1107-E1112
16. Giri S., Nath N., Smith B., Viollet B., Singh A.K., and Singh I. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMPK-activated protein kinase. J. Neurosci. 24 (2004) 479-487
17. Okoshi R., Ozaki T., Yamamoto H., Ando K., Koida N., Ono S., Koda T., Kamijo T., Nakagawara A., and Kizaki H. Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J. Biol. Chem. 283 (2008) 3979-3987
18. Jones R.G., Plas D.R., Kubek S., Buzzai M., Mu J., Xu Y., Birnbaum M.J., and Thompson C.B. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18 (2005) 283-293
19. Hwang S.L., Yang B.K., Lee J.Y., Kim J.H., Kim B.H., Suh K.H., Kim D.Y., Kim M.S., Song H., Park B.S., and Huh T.L. Isodihydrocapsiate stimulates plasma glucose uptake by activation of AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 371 (2008) 289-293
20. Wang Y.X., Lee C.H., Tiep S., Yu R.T., Ham J., Kang H., and Evans R.M. Peroxisome-proliferator-activated receptor activates fat metabolism to prevent obesity. Cell 113 (2003) 159-170
21. Yoon M.J., Lee G.Y., Chung J.J., Ahn Y.H., Hong S.H., and Kim J.B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor α. Diabetes 55 (2006) 2562-2570
22. Hyde R., Christie G.R., Litherland G.J., Hajduch E., Taylor P.M., and Hundal H.S. Subcellular localization and adaptive up-regulation of the System A(SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. Biochem. J. 355 (2001) 563-568
23. Ma W.J., Xiao D.J., and Deng S.Z. Studies on chemical constituents of the marine sponge Spheciospongia vagabunda from the South China Sea. Zhongguo Haiyang Yaowu 23 (2004) 15-17
24. Zhou G., Myers R., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., and Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108 (2001) 1167-1174
25. Schulte T.W., Akinaga S., Soga S., Sullivan W., Stensgard B., Toft D., and Neckers L.M. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 3 (1998) 100-108
26. Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Mäkelä T.P., Alessi D.R., and Hardie D.G. Complexes between the LKB1 tumor suppressor, STRADαβ and MO25αβ are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2 (2003) 28.1-28.16
27. Sun Y., Connors K.E., and Yang D.Q. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol. Cell. Biochem. 306 (2007) 239-245
28. Best M.M., Duncan C.H., van Loon E.J., and Wathen J.D. Lowering of serum cholesterol by the administration of a plant sterol. Circulation 10 (1954) 201-206
29. Gylling H., and Miettinen T.A. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. J. Lipid Res. 37 (1996) 1776-1785
30. Becker M., Staab D., and Bergmann K.V. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J. Pediatr. 122 (1993) 292-296
31. Salen G., Ahrens Jr. E.H., and Grundy S.M. Metabolism of β-sitosterol in man. J. Clin. Invest. 49 (1970) 952-967
32. Ivorra M.D., D'Ocon M.P., Paya M., and Villar A. Anti-hyperglycemic insulin-releasing effects of β-sitosterol3-β-d-glucoside its aglycone β-sitosterol. Arch. Int. Pharmacodyn. Ther. 296 (1998) 224-231
33. Hardie D.G. AMP-activated protein kinase as a drug target. Annu. Rev. Pharmacol. Toxicol. 47 (2007) 185-210
34. Bouic P.J., Clark A., Lamprecht J., Freestone M., Pool E.J., Liebenberg R.W., Kotze D., and Jaarsveld P.P. The effects of β-sitosterol (BSS) and β-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation. Int. J. Sports Med. 20 (1999) 258-262
35. Awad A.B., and Fink C.S. Phytosterols as anticancer dietary components: evidence and mechanism of action. J. Nutr. 130 (2000) 2127-2130