-
1
-
-
0028911690
-
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
-
Uehara Y., et al. (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373:702-705.
-
(1995)
Nature
, vol.373
, pp. 702-705
-
-
Uehara, Y.1
-
2
-
-
0028899952
-
Scatter factor/hepatocyte growth factor is essential for liver development
-
Schmidt C., et al. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702.
-
(1995)
Nature
, vol.373
, pp. 699-702
-
-
Schmidt, C.1
-
3
-
-
0029134104
-
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
-
Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768-771.
-
(1995)
Nature
, vol.376
, pp. 768-771
-
-
Bladt, F.1
Riethmacher, D.2
Isenmann, S.3
Aguzzi, A.4
Birchmeier, C.5
-
4
-
-
0345601083
-
Met, metastasis, motility and more
-
DOI 10.1038/nrm1261
-
Birchmeier C., Birchmeier W., Gherardi E., Vande Woude G.F. (2003) Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4:915-925. (Pubitemid 37493640)
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, Issue.12
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande, W.G.F.4
-
6
-
-
48849101466
-
Developing therapeutic proteins by engineering ligand-receptor interactions
-
Jones D.S., Silverman A.P., Cochran J.R. (2008) Developing therapeutic proteins by engineering ligand-receptor interactions. Trends Biotechnol 26:498-505.
-
(2008)
Trends Biotechnol
, vol.26
, pp. 498-505
-
-
Jones, D.S.1
Silverman, A.P.2
Cochran, J.R.3
-
7
-
-
0028567137
-
Molecular evolution and domain structure of plasminogenrelated growth factors (HGF/SF and HGF1/MSP)
-
Donate L.E., et al. (1994) Molecular evolution and domain structure of plasminogenrelated growth factors (HGF/SF and HGF1/MSP). Protein Sci 3:2378-2394.
-
(1994)
Protein Sci
, vol.3
, pp. 2378-2394
-
-
Donate, L.E.1
-
8
-
-
33645235265
-
Structural basis of hepatocyte growth factor/scatter factor and MET signalling
-
Gherardi E., et al. (2006) Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci USA 103:4046-4051.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4046-4051
-
-
Gherardi, E.1
-
9
-
-
3142619403
-
The Sema domain of Met is necessary for receptor dimerization and activation
-
DOI 10.1016/j.ccr.2004.06.013, PII S1535610804001801
-
Kong-Beltran M., Stamos J., Wickramasinghe D. (2004) The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6:75-84. (Pubitemid 38903163)
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 75-84
-
-
Kong-Beltran, M.1
Stamos, J.2
Wickramasinghe, D.3
-
10
-
-
0142091400
-
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
-
DOI 10.1073/pnas.2034936100
-
Gherardi E., et al. (2003) Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor. Proc Natl Acad Sci USA 100:12039-12044. (Pubitemid 37271511)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12039-12044
-
-
Gherardi, E.1
Youles, M.E.2
Miguel, R.N.3
Blundell, T.L.4
Iamele, L.5
Gough, J.6
Bandyopadhyay, A.7
Hartmann, G.8
Butler, P.J.G.9
-
11
-
-
51049117095
-
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
-
Basilico C., Arnesano A., Galluzzo M., Comoglio P.M., Michieli P. (2008) A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J Biol Chem 283:21267-21277.
-
(2008)
J Biol Chem
, vol.283
, pp. 21267-21277
-
-
Basilico, C.1
Arnesano, A.2
Galluzzo, M.3
Comoglio, P.M.4
Michieli, P.5
-
12
-
-
85047689927
-
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
-
DOI 10.1172/JCI200422235
-
Mazzone M., et al. (2004) An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice. J Clin Invest 114:1418-1432. (Pubitemid 40385573)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.10
, pp. 1418-1432
-
-
Mazzone, M.1
Basilico, C.2
Cavassa, S.3
Pennacchietti, S.4
Risio, M.5
Naldini, L.6
Comoglio, P.M.7
Michieli, P.8
-
13
-
-
34248335027
-
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist
-
DOI 10.1073/pnas.0700184104
-
Kirchhofer D., et al. (2007) Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist. Proc Natl Acad Sci USA 104:5306-5311. (Pubitemid 47175676)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.13
, pp. 5306-5311
-
-
Kirchhofer, D.1
Lipari, M.T.2
Santell, L.3
Billeci, K.L.4
Maun, H.R.5
Sandoval, W.N.6
Moran, P.7
Ridgway, J.8
Eigenbrot, C.9
Lazarus, R.A.10
-
14
-
-
0031583998
-
HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factore
-
DOI 10.1016/S0014-5793(97)01475-0, PII S0014579397014750
-
Date K., Matsumoto K., Shimura H., Tanaka M., Nakamura T. (1997) HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett 420:1-6. (Pubitemid 28037188)
-
(1997)
FEBS Letters
, vol.420
, Issue.1
, pp. 1-6
-
-
Date, K.1
Matsumoto, K.2
Shimura, H.3
Tanaka, M.4
Nakamura, T.5
-
15
-
-
0029897025
-
Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2
-
DOI 10.1083/jcb.133.3.709
-
Schwall R.H., et al. (1996) Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2. J Cell Biol 133:709-718. (Pubitemid 26163342)
-
(1996)
Journal of Cell Biology
, vol.133
, Issue.3
, pp. 709-718
-
-
Schwall, R.H.1
Chang, L.Y.2
Godowski, P.J.3
Kahn, D.W.4
Hillan, K.J.5
Bauer, K.D.6
Zioncheck, T.F.7
-
16
-
-
0035887033
-
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
-
DOI 10.1093/emboj/20.20.5543
-
Lietha D., Chirgadze D.Y., Mulloy B., Blundell T.L., Gherardi E. (2001) Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor. EMBO J 20:5543-5555. (Pubitemid 33010032)
-
(2001)
EMBO Journal
, vol.20
, Issue.20
, pp. 5543-5555
-
-
Lietha, D.1
Chirgadze, D.Y.2
Mulloy, B.3
Blundell, T.L.4
Gherardi, E.5
-
17
-
-
0032957467
-
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding
-
DOI 10.1038/4947
-
Chirgadze D.Y., et al. (1999) Crystal structure of the NK1 fragment of HGF/SF suggests a novelmode for growth factor dimerization and receptor binding. Nat Struct Biol 6:72-79. (Pubitemid 29232427)
-
(1999)
Nature Structural Biology
, vol.6
, Issue.1
, pp. 72-79
-
-
Chirgadze, D.Y.1
Hepple, J.P.2
Zhou, H.3
Andrew, B.R.4
Blundell, T.L.5
Gherardi, E.6
-
18
-
-
40849135544
-
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist
-
Youles M., et al. (2008) Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist. J Mol Biol 377:616-622.
-
(2008)
J Mol Biol
, vol.377
, pp. 616-622
-
-
Youles, M.1
-
19
-
-
35548953605
-
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
-
DOI 10.1073/pnas.0704290104
-
Tolbert W.D., et al. (2007) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proc Natl Acad Sci USA 104:14592-14597. (Pubitemid 350003189)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.37
, pp. 14592-14597
-
-
Tolbert, W.D.1
Daugherty, J.2
Gao, C.3
Xie, Q.4
Miranti, C.5
Gherardi, E.6
Woude, G.V.7
Xu, H.E.8
-
20
-
-
77955810458
-
Structural basis for agonism and antagonism of hepatocyte growth factor
-
Tolbert W.D., Daugherty-Holtrop J., Gherardi E., VandeWoude G., Xu H.E. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci USA 107:13264-13269.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13264-13269
-
-
Tolbert, W.D.1
Daugherty-Holtrop, J.2
Gherardi, E.3
VandeWoude, G.4
Xu, H.E.5
-
21
-
-
0026734672
-
Structure-function analysis of hepatocyte growth factor: Identification of variants that lack mitogenic activity yet retain high affinity receptor binding
-
Lokker N.A., et al. (1992) Structure-function analysis of hepatocyte growth factor: Identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J 11:2503-2510.
-
(1992)
EMBO J
, vol.11
, pp. 2503-2510
-
-
Lokker, N.A.1
-
22
-
-
0141988690
-
c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
-
Ma P.C., et al. (2003) c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 63:6272-6281. (Pubitemid 37255174)
-
(2003)
Cancer Research
, vol.63
, Issue.19
, pp. 6272-6281
-
-
Ma, P.C.1
Kijima, T.2
Maulik, G.3
Fox, E.A.4
Sattler, M.5
Griffin, J.D.6
Johnson, B.E.7
Salgia, R.8
-
23
-
-
0030830051
-
Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli
-
Stahl S.J., et al. (1997) Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli. Biochem J 326:763-772. (Pubitemid 27438050)
-
(1997)
Biochemical Journal
, vol.326
, Issue.3
, pp. 763-772
-
-
Stahl, S.J.1
Wingfield, P.T.2
Kaufman, J.D.3
Pannell, L.K.4
Cioce, V.5
Sakata, H.6
Taylor, W.G.7
Rubin, J.S.8
Bottaro, D.P.9
-
24
-
-
0027501381
-
Circular dichroic analysis of denatured proteins: Inclusion of denatured proteins in the reference set
-
DOI 10.1006/abio.1993.1450
-
Venyaminov S., Baikalov I.A., Shen Z.M., Wu C.S., Yang J.T. (1993) Circular dichroic analysis of denatured proteins: Inclusion of denatured proteins in the reference set. Anal Biochem 214:17-24. (Pubitemid 23300347)
-
(1993)
Analytical Biochemistry
, vol.214
, Issue.1
, pp. 17-24
-
-
Venyaminov, S.Y.1
Baikalov, I.A.2
Shen, Z.M.3
Wu, C.-S.C.4
Yang, J.T.5
-
25
-
-
33847152551
-
Insights into the Structure/Function of Hepatocyte Growth Factor/Scatter Factor from Studies with Individual Domains
-
DOI 10.1016/j.jmb.2006.12.061, PII S0022283606017517
-
Holmes O., et al. (2007) Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains. J Mol Biol 367:395-408. (Pubitemid 46295423)
-
(2007)
Journal of Molecular Biology
, vol.367
, Issue.2
, pp. 395-408
-
-
Holmes, O.1
Pillozzi, S.2
Deakin, J.A.3
Carafoli, F.4
Kemp, L.5
Butler, P.J.G.6
Lyon, M.7
Gherardi, E.8
-
26
-
-
34247176809
-
Isolating and engineering human antibodies using yeast surface display
-
Chao G., et al. (2006) Isolating and engineering human antibodies using yeast surface display. Nat Protoc 1:755-768.
-
(2006)
Nat Protoc
, vol.1
, pp. 755-768
-
-
Chao, G.1
-
27
-
-
0033748716
-
Yeast surface display for directed evolution of protein expression, affinity, and stability
-
Boder E.T., Wittrup K.D. (2000) Yeast surface display for directed evolution of protein expression, affinity, and stability. Methods Enzymol 328:430-444.
-
(2000)
Methods Enzymol
, vol.328
, pp. 430-444
-
-
Boder, E.T.1
Wittrup, K.D.2
-
28
-
-
0033926329
-
Directed evolution of a stable scaffold for T-cell receptor engineering
-
DOI 10.1038/77325
-
Shusta E.V., Holler P.D., Kieke M.C., Kranz D.M., Wittrup K.D. (2000) Directed evolution of a stable scaffold for T-cell receptor engineering. Nat Biotechnol 18:754-759. (Pubitemid 30460692)
-
(2000)
Nature Biotechnology
, vol.18
, Issue.7
, pp. 754-759
-
-
Shusta, E.V.1
Holler, P.D.2
Kieke, M.C.3
Kranz, D.M.4
Wittrup, K.D.5
-
29
-
-
0033536626
-
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency
-
DOI 10.1006/jmbi.1999.3130
-
Shusta E.V., Kieke M.C., Parke E., Kranz D.M., Wittrup K.D. (1999) Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. J Mol Biol 292:949-956. (Pubitemid 29481708)
-
(1999)
Journal of Molecular Biology
, vol.292
, Issue.5
, pp. 949-956
-
-
Shusta, E.V.1
Kieke, M.C.2
Parke, E.3
Kranz, D.M.4
Wittrup, K.D.5
-
30
-
-
77954757013
-
Stability and CDR composition biases enrich binder functionality landscapes
-
Hackel B.J., Ackerman M.E., Howland S.W., Wittrup K.D. (2010) Stability and CDR composition biases enrich binder functionality landscapes. J Mol Biol 401:84-96.
-
(2010)
J Mol Biol
, vol.401
, pp. 84-96
-
-
Hackel, B.J.1
Ackerman, M.E.2
Howland, S.W.3
Wittrup, K.D.4
-
31
-
-
33745726188
-
Improved mutants from directed evolution are biased to orthologous substitutions
-
Cochran J.R., Kim Y.S., Lippow S.M., Rao B.M., Wittrup K.D. (2006) Improved mutants from directed evolution are biased to orthologous substitutions. Protein Eng Des Sel 19:245-253.
-
(2006)
Protein Eng des Sel
, vol.19
, pp. 245-253
-
-
Cochran, J.R.1
Kim, Y.S.2
Lippow, S.M.3
Rao, B.M.4
Wittrup, K.D.5
-
32
-
-
0028177817
-
Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor
-
Lokker N.A., Presta L.G., Godowski P.J. (1994)Mutational analysis andmolecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor. Protein Eng 7:895-903. (Pubitemid 24219959)
-
(1994)
Protein Engineering
, vol.7
, Issue.7
, pp. 895-903
-
-
Lokker, N.A.1
Presta, L.G.2
Godowski, P.J.3
-
33
-
-
46249085219
-
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis
-
DOI 10.1002/hep.22243
-
Takahara T., et al. (2008) Metron factor-1 prevents liver injury without promoting tumor growth and metastasis. Hepatology 47:2010-2025. (Pubitemid 351945568)
-
(2008)
Hepatology
, vol.47
, Issue.6
, pp. 2010-2025
-
-
Takahara, T.1
Xue, F.2
Mazzone, M.3
Yata, Y.4
Nonome, K.5
Kanayama, M.6
Kawai, K.7
Pisacane, A.M.8
Takahara, S.9
Li, X.-K.10
Comoglio, P.M.11
Sugiyama, T.12
Michieli, P.13
-
34
-
-
52449098259
-
Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis
-
Cassano M., et al. (2008) Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. PLoS One 3:e3223.
-
(2008)
PLoS One
, vol.3
-
-
Cassano, M.1
-
35
-
-
0036246707
-
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
-
DOI 10.1038/nbt0502-488
-
Michieli P., et al. (2002) An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity. Nat Biotechnol 20:488-495. (Pubitemid 34495936)
-
(2002)
Nature Biotechnology
, vol.20
, Issue.5
, pp. 488-495
-
-
Michieli, P.1
Cavassa, S.2
Basilico, C.3
De Luca, A.4
Mazzone, M.5
Asti, C.6
Chiusaroli, R.7
Guglielmi, M.8
Bossu, P.9
Colotta, F.10
Caselli, G.11
Comoglio, P.M.12
-
36
-
-
77956363290
-
Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis
-
Sinha Roy R., et al. (2010) Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci USA 107:13608-13613.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13608-13613
-
-
Sinha Roy, R.1
-
37
-
-
0029869449
-
An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues
-
DOI 10.1006/jmbi.1996.0049
-
Zaccolo M., Williams D.M., Brown D.M., Gherardi E. (1996) An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues. J Mol Biol 255:589-603. (Pubitemid 26107188)
-
(1996)
Journal of Molecular Biology
, vol.255
, Issue.4
, pp. 589-603
-
-
Zaccolo, M.1
Williams, D.M.2
Brown, D.M.3
Gherardi, E.4
-
38
-
-
2342510292
-
Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display
-
Swers J.S., Kellogg B.A., Wittrup K.D. (2004) Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display. Nucleic Acids Res 32:e36.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Swers, J.S.1
Kellogg, B.A.2
Wittrup, K.D.3
|