Pattern of cavities in globins: The case of human hemoglobin

Biopolymers - Peptide Science Section

Volumn 91, Issue 12, 2009, Pages 1097-1107

  Savino, Carmelinda ^a   Miele, Adriana E ^a   Draghi, Federica ^a,b   Johnson, Kenneth A ^a,c   Sciara, Giuliano ^a,d   Brunori, Maurizio ^a   Vallone, Beatrice ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Genextra SpA   (Italy)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Globin fold; Hydrophobic cavities; Packing defects; Structure function relationship; X ray diffraction

Indexed keywords

BINDING CAVITY; DOCKING SITES; EXPERIMENTAL CONDITIONS; HIGH-RESOLUTION STRUCTURES; HYDROPHOBIC CAVITIES; INTERNAL CAVITIES; PACKING DEFECT; POTENTIAL LIGAND; SPERM WHALES; WILD TYPES; XENON ATOMS;

DIFFRACTION; DOCKING; HYDROPHOBICITY; LIGANDS; LIGHT; X RAY DIFFRACTION; XENON;

HEMOGLOBIN;

HEMOGLOBIN; HEMOGLOBIN CHAIN; MUTANT PROTEIN; MYOGLOBIN; XENON; GLUTAMINE; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HISTIDINE; LEUCINE; LIGAND; TYROSINE;

ARTICLE; CONTROLLED STUDY; HUMAN; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN STRUCTURE; SPERM WHALE; WILD TYPE; BINDING AFFINITY; BINDING SITE; DEOXYGENATION; GENETIC CONSERVATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

BINDING SITES; GLOBINS; HEMOGLOBINS; HUMANS; MODELS, MOLECULAR; MUTATION; MYOGLOBIN; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS; XENON;

PHYSETERIDAE;

EID: 71749098566     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21201     Document Type: Article

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