Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin

Biochemistry

Volumn 47, Issue 40, 2008, Pages 10551-10563

  Maillett, David H ^a   Simplaceanu, Virgil ^a   Shen, Tong Jian ^a   Ho, Nancy T ^a   Olson, John S ^b   Ho, Chien ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; GENETIC ENGINEERING; OXYGEN; PORPHYRINS;

ADDITIVE EFFECTS; FUNCTIONAL PROPERTIES; HEME POCKETS; OXYGEN CARRIERS; PROTEIN ENGINEERING;

HEMOGLOBIN;

HEMOGLOBIN; MUTANT PROTEIN;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; LIGAND BINDING; OXYGEN AFFINITY; PRIORITY JOURNAL; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

HEME; HEMOGLOBINS; HUMANS; KINETICS; MUTATION; OXYGEN; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 53249127146     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800816v     Document Type: Article

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