Synthesis and evaluation of (S)-4-(3-(2'-isopropylamino)-2- hydroxy-propoxy)-2H-benzimidazol-2-one, [11C]CGP 12388) and [18F]fluoro-CGP 12388) for visualization of β-adrenoceptors with positron emission tomography.

Journal of Medicinal Chemistry

Volumn 40, Issue 23, 1997, Pages 3829-3835

  Elsinga, Philip H ^a   Van Waarde, Aren ^a   Jaeggi, Knut A ^b   Schreiber, Gérard ^b   Heldoorn, Marco ^a   Vaalburg, Willem ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [3 (2' ISOPROPYLAMINO) 2 HYDROXYPROPOXY] 2H BENZIMIDAZOL 2 ONE C 11; 4 [3 (ISOPROPYLAMINO) 2 HYDROXYPROPOXY] 2H BENZIMIDAZOL 2 ONE; 4 [3 [(1' FLUOROISOPROPYL)AMINO] 2 HYDROXYPROPOXY] 2H BENZIMIDAZOL 2 ONE F 18; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CGP 12388; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BLOOD BRAIN BARRIER; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HALF LIFE TIME; LIGAND BINDING; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; RECEPTOR DENSITY; TISSUE DISTRIBUTION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BENZIMIDAZOLES; CARBON RADIOISOTOPES; CHEMISTRY, PHYSICAL; DRUG STABILITY; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030783871     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970267h     Document Type: Article

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