Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5605-5609

  Page, Brent D G ^a   Fletcher, Steven ^a   Yue, Peibin ^b   Li, Zhihua ^c   Zhang, Xiaolei ^b   Sharmeen, Sumaiya ^c   Datti, Alessandro ^d   Wrana, Jeffrey L ^d,e   Trudel, Suzanne ^c   Schimmer, Aaron D ^c   Turkson, James ^b   Gunning, Patrick T ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cancer therapeutics; Inhibitors of apoptosis; Jak Stat pathway; Protein protein interaction; Stat3

Indexed keywords

ANTINEOPLASTIC AGENT; SALICYLIC ACID; STAT3 PROTEIN; SULFONAMIDE;

ARTICLE; CELL DEATH; COMPLEX FORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; SALICYLIC ACID; SMALL MOLECULE LIBRARIES; SRC HOMOLOGY DOMAINS; STAT3 TRANSCRIPTION FACTOR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051927148     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.056     Document Type: Article

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