메뉴 건너뛰기




Volumn 52, Issue 7, 2011, Pages 4158-4168

Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: Changes in immune function, vascularization, and differentiation

Author keywords

[No Author keywords available]

Indexed keywords

CHITINASE; CHITINASE 3 LIKE 3 PROTEIN; CHITINASE 3 LIKE 4 PROTEIN; KERATIN; LIPID BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 3; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX18; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; CYTOKERATIN 12; EYE PROTEIN; FLT1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; SCLEROPROTEIN; SIGNAL PEPTIDE; VASCULOTROPIN RECEPTOR 1; WIF1 PROTEIN, MOUSE; WNT PROTEIN; YM2 PROTEIN, MOUSE;

EID: 80051923954     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6726     Document Type: Article
Times cited : (47)

References (71)
  • 1
    • 0022558958 scopus 로고
    • Small eyes (Sey): A homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse
    • Hogan BL, Horsburgh G, Cohen J, Hetherington CM, Fisher G, Lyon MF. Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J Embryol Exp Morphol. 1986;97: 95-110.
    • (1986) J Embryol Exp Morphol. , vol.97 , pp. 95-110
    • Hogan, B.L.1    Horsburgh, G.2    Cohen, J.3    Hetherington, C.M.4    Fisher, G.5    Lyon, M.F.6
  • 2
    • 0242268030 scopus 로고    scopus 로고
    • Role of Pax genes in eye evolution: A cnidarian PaxB gene uniting Pax2 and Pax6 functions
    • Nov 5
    • Kozmik Z, Daube M, Frei E, et al. Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Dev Cell. Nov 5(5):773-785, 2003.
    • (2003) Dev Cell. , Issue.5 , pp. 773-785
    • Kozmik, Z.1    Daube, M.2    Frei, E.3
  • 3
    • 0028944665 scopus 로고
    • Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    • Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science. 1995;267(5205):1788-1792.
    • (1995) Science. , vol.267 , Issue.5205 , pp. 1788-1792
    • Halder, G.1    Callaerts, P.2    Gehring, W.J.3
  • 5
    • 0038010517 scopus 로고    scopus 로고
    • Requirement for Pax6 in corneal morphogenesis: A role in adhesion
    • Davis J, Duncan MK, Robison WG, Jr., Piatigorsky J. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci. 2003;116:2157-2167.
    • (2003) J Cell Sci. , vol.116 , pp. 2157-2167
    • Davis, J.1    Duncan, M.K.2    Robison Jr., W.G.3    Piatigorsky, J.4
  • 6
    • 0025200949 scopus 로고
    • A mouse model of the aniridia-Wilms tumor deletion syndrome
    • Glaser T, Lane J, Housman D. A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990;250(4982):823-827.
    • (1990) Science. , vol.250 , Issue.4982 , pp. 823-827
    • Glaser, T.1    Lane, J.2    Housman, D.3
  • 7
    • 0028308664 scopus 로고
    • Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
    • Hanson IM, Fletcher JM, Jordan T, et al. Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. Nat Genet. 1994;6(2):168-173.
    • (1994) Nat Genet. , vol.6 , Issue.2 , pp. 168-173
    • Hanson, I.M.1    Fletcher, J.M.2    Jordan, T.3
  • 8
    • 0026345992 scopus 로고
    • Mouse small eye results from mutations in a paired-like homeobox-containing gene
    • Hill RE, Favor J, Hogan BL, et al. Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature. 1991;354(6354):522-525.
    • (1991) Nature. , vol.354 , Issue.6354 , pp. 522-525
    • Hill, R.E.1    Favor, J.2    Hogan, B.L.3
  • 10
    • 0027506485 scopus 로고
    • A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells
    • Matsuo T, Osumi-Yamashita N, Noji S, et al. A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet. 1993;3(4):299-304.
    • (1993) Nat Genet. , vol.3 , Issue.4 , pp. 299-304
    • Matsuo, T.1    Osumi-Yamashita, N.2    Noji, S.3
  • 11
    • 49449084501 scopus 로고    scopus 로고
    • Chronic wound state exacerbated by oxidative stress in Pax6+/-aniridia-related keratopathy. J Pathol
    • Ou J, Walczysko P, Kucerova R, et al. Chronic wound state exacerbated by oxidative stress in Pax6+/-aniridia-related keratopathy. J Pathol. Aug 2008;215(4):421-430.
    • (2008) Aug , vol.215 , Issue.4 , pp. 421-430
    • Ou, J.1    Walczysko, P.2    Kucerova, R.3
  • 13
    • 33744761463 scopus 로고    scopus 로고
    • Increased apoptosis and abnormal wound-healing responses in the heterozygous Pax6+/-mouse cornea
    • Ramaesh T, Ramaesh K, Leask R, et al. Increased apoptosis and abnormal wound-healing responses in the heterozygous Pax6+/-mouse cornea. Invest Ophthalmol Vis Sci. 2006;47(5):1911-1917.
    • (2006) Invest Ophthalmol Vis Sci. , vol.47 , Issue.5 , pp. 1911-1917
    • Ramaesh, T.1    Ramaesh, K.2    Leask, R.3
  • 14
    • 23144450061 scopus 로고    scopus 로고
    • Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/-mouse model of aniridia
    • Ramaesh T, Ramaesh K, Martin Collinson J, Chanas SA, Dhillon B, West JD. Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/-mouse model of aniridia. Exp Eye Res. 2005;81(2):224-235.
    • (2005) Exp Eye Res. , vol.81 , Issue.2 , pp. 224-235
    • Ramaesh, T.1    Ramaesh, K.2    Martin Collinson, J.3    Chanas, S.A.4    Dhillon, B.5    West, J.D.6
  • 15
    • 0030671068 scopus 로고    scopus 로고
    • Tandem duplication of 11p12-p13 in a child with borderline development delay and eye abnormalities: Dose effect of the PAX6 gene product?
    • Aalfs CM, Fantes JA, Wenniger-Prick LJ, et al. Tandem duplication of 11p12-p13 in a child with borderline development delay and eye abnormalities: dose effect of the PAX6 gene product? Am J Med Genet. 1997;73(3):267-271.
    • (1997) Am J Med Genet. , vol.73 , Issue.3 , pp. 267-271
    • Aalfs, C.M.1    Fantes, J.A.2    Wenniger-Prick, L.J.3
  • 16
    • 0030581164 scopus 로고    scopus 로고
    • Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities
    • Schedl A, Ross A, Lee M, et al. Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell. 1996;86(1):71-82.
    • (1996) Cell. , vol.86 , Issue.1 , pp. 71-82
    • Schedl, A.1    Ross, A.2    Lee, M.3
  • 17
    • 70349241740 scopus 로고    scopus 로고
    • Effects of elevated Pax6 expression and genetic background on mouse eye development
    • Chanas SA, Collinson JM, Ramaesh T, et al. Effects of elevated Pax6 expression and genetic background on mouse eye development. Invest Ophthalmol Vis Sci. 2009;50(9):4045-4059.
    • (2009) Invest Ophthalmol Vis Sci. , vol.50 , Issue.9 , pp. 4045-4059
    • Chanas, S.A.1    Collinson, J.M.2    Ramaesh, T.3
  • 18
    • 43449103925 scopus 로고    scopus 로고
    • PAX6 dosage effects on corneal development, growth, and wound healing
    • Dora N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM. PAX6 dosage effects on corneal development, growth, and wound healing. Dev Dyn. 2008;237(5):1295-1306.
    • (2008) Dev Dyn. , vol.237 , Issue.5 , pp. 1295-1306
    • Dora, N.1    Ou, J.2    Kucerova, R.3    Parisi, I.4    West, J.D.5    Collinson, J.M.6
  • 19
    • 11144273257 scopus 로고    scopus 로고
    • Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy
    • Ramaesh K, Ramaesh T, Dutton GN, Dhillon B. Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy. Int J Biochem Cell Biol. 2005;37(3):547-557.
    • (2005) Int J Biochem Cell Biol. , vol.37 , Issue.3 , pp. 547-557
    • Ramaesh, K.1    Ramaesh, T.2    Dutton, G.N.3    Dhillon, B.4
  • 20
    • 0032547830 scopus 로고    scopus 로고
    • Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development
    • McGowan KM, Coulombe PA. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998;143(2):469-486.
    • (1998) J Cell Biol. , vol.143 , Issue.2 , pp. 469-486
    • McGowan, K.M.1    Coulombe, P.A.2
  • 21
    • 14844343588 scopus 로고    scopus 로고
    • Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals
    • Pearton DJ, Yang Y, Dhouailly D. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals. Proc Natl Acad Sci U S A. 2005;102(10):3714-3719.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.10 , pp. 3714-3719
    • Pearton, D.J.1    Yang, Y.2    Dhouailly, D.3
  • 22
    • 33745618132 scopus 로고    scopus 로고
    • Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
    • Mukhopadhyay M, Gorivodsky M, Shtrom S, et al. Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development. 2006;133(11):2149-2154.
    • (2006) Development. , vol.133 , Issue.11 , pp. 2149-2154
    • Mukhopadhyay, M.1    Gorivodsky, M.2    Shtrom, S.3
  • 23
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas M, Wolfer A, Raj K, et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet. 2003;33(3):416-421.
    • (2003) Nat Genet. , vol.33 , Issue.3 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3
  • 24
    • 34547477930 scopus 로고    scopus 로고
    • Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
    • Vauclair S, Majo F, Durham AD, Ghyselinck NB, Barrandon Y, Radtke F. Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell. 2007;13(2):242-253.
    • (2007) Dev Cell. , vol.13 , Issue.2 , pp. 242-253
    • Vauclair, S.1    Majo, F.2    Durham, A.D.3    Ghyselinck, N.B.4    Barrandon, Y.5    Radtke, F.6
  • 25
    • 77249170249 scopus 로고    scopus 로고
    • Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/betacatenin signaling in the lens surface ectoderm
    • Machon O, Kreslova J, Ruzickova J, et al. Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/betacatenin signaling in the lens surface ectoderm. Genesis. 2010; 48(2):86-95.
    • (2010) Genesis. , vol.48 , Issue.2 , pp. 86-95
    • Machon, O.1    Kreslova, J.2    Ruzickova, J.3
  • 27
    • 0014848872 scopus 로고
    • The prenatal development of the mouse eye
    • Pei YF, Rhodin JA. The prenatal development of the mouse eye. Anat Rec. 1970;168(1):105-125.
    • (1970) Anat Rec. , vol.168 , Issue.1 , pp. 105-125
    • Pei, Y.F.1    Rhodin, J.A.2
  • 28
    • 0035859899 scopus 로고    scopus 로고
    • Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye
    • Collinson JM, Quinn JC, Buchanan MA, et al. Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye. Proc Natl Acad Sci U S A. 2001;98(17):9688-9693.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , Issue.17 , pp. 9688-9693
    • Collinson, J.M.1    Quinn, J.C.2    Buchanan, M.A.3
  • 29
    • 0014009334 scopus 로고
    • Role of the lens in the morphogenesis of the iris and cornea
    • Genis-Galvez JM. Role of the lens in the morphogenesis of the iris and cornea. Nature. 1966;210(32):209-210.
    • (1966) Nature. , vol.210 , Issue.32 , pp. 209-210
    • Genis-Galvez, J.M.1
  • 30
    • 0014035180 scopus 로고
    • Causal factors in corneal development: An experimental analysis in the chick embryo
    • Genis-Galvez JM, Santos-Gutierrez L, Rios-Gonzalez A. Causal factors in corneal development: an experimental analysis in the chick embryo. Exp Eye Res. 1967;6(1):48-56.
    • (1967) Exp Eye Res. , vol.6 , Issue.1 , pp. 48-56
    • Genis-Galvez, J.M.1    Santos-Gutierrez, L.2    Rios-Gonzalez, A.3
  • 31
    • 0031033915 scopus 로고    scopus 로고
    • The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia
    • Koroma BM, Yang JM, Sundin OH. The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci. 1997;38(1):108-120.
    • (1997) Invest Ophthalmol Vis Sci. , vol.38 , Issue.1 , pp. 108-120
    • Koroma, B.M.1    Yang, J.M.2    Sundin, O.H.3
  • 32
    • 44949168456 scopus 로고    scopus 로고
    • Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    • Manuel M, Pratt T, Liu M, Jeffery G, Price DJ. Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol. 2008;8:59.
    • (2008) BMC Dev Biol. , vol.8 , pp. 59
    • Manuel, M.1    Pratt, T.2    Liu, M.3    Jeffery, G.4    Price, D.J.5
  • 33
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • Ashery-Padan R, Marquardt T, Zhou X, Gruss P. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000;14(21): 2701-2711.
    • (2000) Genes Dev. , vol.14 , Issue.21 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.3    Gruss, P.4
  • 34
    • 0031444180 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase class 3 expression: Identification of a cornea-preferred gene promoter in transgenic mice
    • Kays WT, Piatigorsky J. Aldehyde dehydrogenase class 3 expression: identification of a cornea-preferred gene promoter in transgenic mice. Proc Natl Acad Sci U S A. 1997;94(25):13594-13599.
    • (1997) Proc Natl Acad Sci U S A. , vol.94 , Issue.25 , pp. 13594-13599
    • Kays, W.T.1    Piatigorsky, J.2
  • 35
    • 44649154654 scopus 로고    scopus 로고
    • Gene expression of the mouse corneal crystallin Aldh3a1: Activation by Pax6, Oct1, and p300
    • Davis J, Davis D, Norman B, Piatigorsky J. Gene expression of the mouse corneal crystallin Aldh3a1: activation by Pax6, Oct1, and p300. Invest Ophthalmol Vis Sci. 2008;49(5):1814-1826.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , Issue.5 , pp. 1814-1826
    • Davis, J.1    Davis, D.2    Norman, B.3    Piatigorsky, J.4
  • 36
    • 33645808222 scopus 로고    scopus 로고
    • Large scale real-time PCR validation on gene expression measurements from two commercial long-oligonucleotide microarrays
    • Wang Y, Barbacioru C, Hyland F, et al. Large scale real-time PCR validation on gene expression measurements from two commercial long-oligonucleotide microarrays. BMC Genomics. 2006;7:59.
    • (2006) BMC Genomics. , vol.7 , pp. 59
    • Wang, Y.1    Barbacioru, C.2    Hyland, F.3
  • 37
    • 33750430869 scopus 로고    scopus 로고
    • Corneal avascularity is due to soluble VEGF receptor-1
    • Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;26 443(7114):993-997.
    • (2006) Nature , vol.26-443 , Issue.7114 , pp. 993-997
    • Ambati, B.K.1    Nozaki, M.2    Singh, N.3
  • 38
    • 0033786113 scopus 로고    scopus 로고
    • Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression
    • Duncan MK, Kozmik Z, Cveklova K, Piatigorsky J, Cvekl A. Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression. J Cell Sci. 2000;113:3173-3185.
    • (2000) J Cell Sci. , vol.113 , pp. 3173-3185
    • Duncan, M.K.1    Kozmik, Z.2    Cveklova, K.3    Piatigorsky, J.4    Cvekl, A.5
  • 39
    • 33750350276 scopus 로고    scopus 로고
    • Long-range downstream enhancers are essential for Pax6 expression
    • Kleinjan DA, Seawright A, Mella S, et al. Long-range downstream enhancers are essential for Pax6 expression. Dev Biol. 2006;15 299(2):563-581.
    • (2006) Dev Biol. , vol.15-299 , Issue.2 , pp. 563-581
    • Kleinjan, D.A.1    Seawright, A.2    Mella, S.3
  • 40
    • 0030696668 scopus 로고    scopus 로고
    • Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye (Pax6Sey/Pax6Sey) mice
    • Quinn JC, West JD, Kaufman MH. Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye (Pax6Sey/Pax6Sey) mice. Anat Embryol (Berl). 1997;196(4): 311-321.
    • (1997) Anat Embryol (Berl). , vol.196 , Issue.4 , pp. 311-321
    • Quinn, J.C.1    West, J.D.2    Kaufman, M.H.3
  • 41
    • 67650627746 scopus 로고    scopus 로고
    • Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development
    • Ramaesh T, Williams SE, Paul C, Ramaesh K, Dhillon B, West JD. Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development. Exp Eye Res. 2009;89(2):263-273.
    • (2009) Exp Eye Res. , vol.89 , Issue.2 , pp. 263-273
    • Ramaesh, T.1    Williams, S.E.2    Paul, C.3    Ramaesh, K.4    Dhillon, B.5    West, J.D.6
  • 42
    • 0034656096 scopus 로고    scopus 로고
    • The lens organizes the anterior segment: Specification of neural crest cell differentiation in the avian eye
    • Beebe DC, Coats JM. The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye. Dev Biol. 2000;220(2):424-431.
    • (2000) Dev Biol. , vol.220 , Issue.2 , pp. 424-431
    • Beebe, D.C.1    Coats, J.M.2
  • 43
    • 0022539674 scopus 로고
    • Development of the ciliary body: A brief review
    • Beebe DC. Development of the ciliary body: a brief review. Trans Ophthalmol Soc U K. 1986;105:123-130.
    • (1986) Trans Ophthalmol Soc U K. , vol.105 , pp. 123-130
    • Beebe, D.C.1
  • 44
    • 33847395395 scopus 로고    scopus 로고
    • Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    • Manuel M, Georgala PA, Carr CB, et al. Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development. 2007; 134(3):545-555.
    • (2007) Development. , vol.134 , Issue.3 , pp. 545-555
    • Manuel, M.1    Georgala, P.A.2    Carr, C.B.3
  • 45
    • 33645949095 scopus 로고    scopus 로고
    • Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb
    • Kim J, Lauderdale JD. Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol. 2006;292(2):486-505.
    • (2006) Dev Biol. , vol.292 , Issue.2 , pp. 486-505
    • Kim, J.1    Lauderdale, J.D.2
  • 46
    • 0030832612 scopus 로고    scopus 로고
    • Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8
    • Kozmik Z, Czerny T, Busslinger M. Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. EMBO J. 1997;16(22):6793-6803.
    • (1997) EMBO J. , vol.16 , Issue.22 , pp. 6793-6803
    • Kozmik, Z.1    Czerny, T.2    Busslinger, M.3
  • 47
    • 23944484521 scopus 로고    scopus 로고
    • Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain
    • Pinson J, Mason JO, Simpson TI, Price DJ. Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain. BMC Dev Biol. 2005;5:13.
    • (2005) BMC Dev Biol. , vol.5 , pp. 13
    • Pinson, J.1    Mason, J.O.2    Simpson, T.I.3    Price, D.J.4
  • 48
    • 33947493325 scopus 로고    scopus 로고
    • Anatomy and immunology of the ocular surface
    • Knop E, Knop N. Anatomy and immunology of the ocular surface. Chem Immunol Allergy. 2007;92:36-49.
    • (2007) Chem Immunol Allergy. , vol.92 , pp. 36-49
    • Knop, E.1    Knop, N.2
  • 50
    • 0034212574 scopus 로고    scopus 로고
    • Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    • Sivak JM, Mohan R, Rinehart WB, Xu PX, Maas RL, Fini ME. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000;222(1):41-54.
    • (2000) Dev Biol. , vol.222 , Issue.1 , pp. 41-54
    • Sivak, J.M.1    Mohan, R.2    Rinehart, W.B.3    Xu, P.X.4    Maas, R.L.5    Fini, M.E.6
  • 51
    • 74249112137 scopus 로고    scopus 로고
    • Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells
    • Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E. Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells. World J Gastroenterol. 2009;15(42):5249-5259.
    • (2009) World J Gastroenterol. , vol.15 , Issue.42 , pp. 5249-5259
    • Eurich, K.1    Segawa, M.2    Toei-Shimizu, S.3    Mizoguchi, E.4
  • 52
    • 65249097227 scopus 로고    scopus 로고
    • Oxidative stress and asthma: Proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid
    • Zhang L, Wang M, Kang X, et al. Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid. J Proteome Res. 2009;8(4): 1631-1638.
    • (2009) J Proteome Res. , vol.8 , Issue.4 , pp. 1631-1638
    • Zhang, L.1    Wang, M.2    Kang, X.3
  • 53
    • 4344611570 scopus 로고    scopus 로고
    • Light damage induced changes in mouse retinal gene expression
    • Chen L, Wu W, Dentchev T, et al. Light damage induced changes in mouse retinal gene expression. Exp Eye Res. 2004;79(2):239-247.
    • (2004) Exp Eye Res. , vol.79 , Issue.2 , pp. 239-247
    • Chen, L.1    Wu, W.2    Dentchev, T.3
  • 54
    • 33646842919 scopus 로고    scopus 로고
    • Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer
    • Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull. 2006;53(2):172-209.
    • (2006) Dan Med Bull. , vol.53 , Issue.2 , pp. 172-209
    • Johansen, J.S.1
  • 55
    • 0037530029 scopus 로고    scopus 로고
    • gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells
    • Nishikawa KC, Millis AJ. gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Exp Cell Res. 2003;287(1):79-87.
    • (2003) Exp Cell Res. , vol.287 , Issue.1 , pp. 79-87
    • Nishikawa, K.C.1    Millis, A.J.2
  • 56
    • 33745003902 scopus 로고    scopus 로고
    • A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth
    • Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006;441(7091):362-365.
    • (2006) Nature. , vol.441 , Issue.7091 , pp. 362-365
    • Kim, S.1    Wong, P.2    Coulombe, P.A.3
  • 57
    • 0037310404 scopus 로고    scopus 로고
    • Role for keratins 6 and 17 during wound closure in embryonic mouse skin
    • Mazzalupo S, Wong P, Martin P, Coulombe PA. Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev Dyn. 2003;226(2):356-365.
    • (2003) Dev Dyn. , vol.226 , Issue.2 , pp. 356-365
    • Mazzalupo, S.1    Wong, P.2    Martin, P.3    Coulombe, P.A.4
  • 58
    • 38049018919 scopus 로고    scopus 로고
    • Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases
    • Li W, Chen YT, Hayashida Y, et al. Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases. J Pathol. 2008;214(1):114-122.
    • (2008) J Pathol. , vol.214 , Issue.1 , pp. 114-122
    • Li, W.1    Chen, Y.T.2    Hayashida, Y.3
  • 59
    • 77951250927 scopus 로고    scopus 로고
    • Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn
    • Joo JH, Kim YH, Dunn NW, Sugrue SP. Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn. Invest Ophthalmol Vis Sci. 2010;51(4):1927-1934.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , Issue.4 , pp. 1927-1934
    • Joo, J.H.1    Kim, Y.H.2    Dunn, N.W.3    Sugrue, S.P.4
  • 60
    • 33845790551 scopus 로고    scopus 로고
    • Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
    • Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol. 2007;27(1):182-194.
    • (2007) Mol Cell Biol. , vol.27 , Issue.1 , pp. 182-194
    • Swamynathan, S.K.1    Katz, J.P.2    Kaestner, K.H.3    Ashery-Padan, R.4    Crawford, M.A.5    Piatigorsky, J.6
  • 61
    • 77951188818 scopus 로고    scopus 로고
    • Aberrant expression of a betacatenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea
    • Zhang Y, Call MK, Yeh LK, et al. Aberrant expression of a betacatenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci. 2010;123:1285-1294.
    • (2010) J Cell Sci. , vol.123 , pp. 1285-1294
    • Zhang, Y.1    Call, M.K.2    Yeh, L.K.3
  • 62
    • 0022470546 scopus 로고
    • Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells
    • Schermer A, Galvin S, Sun TT. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol. 1986;103(1): 49-62.
    • (1986) J Cell Biol. , vol.103 , Issue.1 , pp. 49-62
    • Schermer, A.1    Galvin, S.2    Sun, T.T.3
  • 63
    • 34247174789 scopus 로고    scopus 로고
    • Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces
    • Yoshida S, Shimmura S, Kawakita T, et al. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci. 2006;47(11):4780-4786.
    • (2006) Invest Ophthalmol Vis Sci. , vol.47 , Issue.11 , pp. 4780-4786
    • Yoshida, S.1    Shimmura, S.2    Kawakita, T.3
  • 64
    • 48749110372 scopus 로고    scopus 로고
    • Immunohistochemical markers for corneal stem cells in the early developing human eye
    • Lyngholm M, Hoyer PE, Vorum H, Nielsen K, Ehlers N, Mollgard K. Immunohistochemical markers for corneal stem cells in the early developing human eye. Exp Eye Res. 2008;87(2):115-121.
    • (2008) Exp Eye Res. , vol.87 , Issue.2 , pp. 115-121
    • Lyngholm, M.1    Hoyer, P.E.2    Vorum, H.3    Nielsen, K.4    Ehlers, N.5    Mollgard, K.6
  • 65
    • 39549098201 scopus 로고    scopus 로고
    • Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease
    • Li S, Nikulina K, DeVoss J, et al. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008;49(1):34-41.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , Issue.1 , pp. 34-41
    • Li, S.1    Nikulina, K.2    DeVoss, J.3
  • 66
    • 0014871421 scopus 로고
    • The induction of keratinization in the corneal epithelium: A comparison of the "dry" and vitamin A-deficient eyes
    • Beitch I. The induction of keratinization in the corneal epithelium: a comparison of the "dry" and vitamin A-deficient eyes. Invest Ophthalmol. 1970;9(11):827-843.
    • (1970) Invest Ophthalmol. , vol.9 , Issue.11 , pp. 827-843
    • Beitch, I.1
  • 67
    • 0031744588 scopus 로고    scopus 로고
    • Alterations of ocular surface gene expression in Sjogren's syndrome
    • Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjogren's syndrome. Adv Exp Med Biol. 1998;438:533-536.
    • (1998) Adv Exp Med Biol. , vol.438 , pp. 533-536
    • Jones, D.T.1    Monroy, D.2    Ji, Z.3    Pflugfelder, S.C.4
  • 68
    • 77952519493 scopus 로고    scopus 로고
    • Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells
    • Li S, Gallup M, Chen YT, McNamara NA. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010; 51(5):2466-2475.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , Issue.5 , pp. 2466-2475
    • Li, S.1    Gallup, M.2    Chen, Y.T.3    McNamara, N.A.4
  • 69
    • 42649083977 scopus 로고    scopus 로고
    • The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development
    • Gage PJ, Qian M, Wu D, Rosenberg KI. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol. 2008;317(1):310-324.
    • (2008) Dev Biol. , vol.317 , Issue.1 , pp. 310-324
    • Gage, P.J.1    Qian, M.2    Wu, D.3    Rosenberg, K.I.4
  • 70
    • 77649181111 scopus 로고    scopus 로고
    • Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
    • Kumar S, Duester G. Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2. Dev Biol. 2010;340(1):67-74.
    • (2010) Dev Biol. , vol.340 , Issue.1 , pp. 67-74
    • Kumar, S.1    Duester, G.2
  • 71
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • Konigshoff M, Kramer M, Balsara N, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 2009;119(4):772-787.
    • (2009) J Clin Invest. , vol.119 , Issue.4 , pp. 772-787
    • Konigshoff, M.1    Kramer, M.2    Balsara, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.