Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5305-5309

  Siles, Rogelio ^a   Kawasaki, Yuko ^a   Ross, Patrick ^a   Freire, Ernesto ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Isothermal titration calorimetry; Sulfonamide synthesis; Thrombosis or thrombin inhibition; Triazole and tetrazole scaffolds; Trypsin selectivity

Indexed keywords

CHYMASE; SERINE PROTEINASE; SULFONAMIDE; TETRAZOLE DERIVATIVE; THROMBIN; TRIAZOLE DERIVATIVE; TRYPSIN; TRYPTASE;

ARTICLE; BINDING AFFINITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION;

CHEMISTRY TECHNIQUES, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAZOLES; THERMODYNAMICS; TRIAZOLES;

EID: 80051918474     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.023     Document Type: Article

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