Human pentraxin 3 binds to the complement regulator c4b-binding protein

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Braunschweig, Anne ^a   Józsi, Mihály ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C4B BINDING PROTEIN; COMPLEMENT COMPONENT C5A; COMPLEMENT FACTOR H; FICOLIN; PENTRAXIN 3; C REACTIVE PROTEIN; CALCIUM; SERUM AMYLOID P;

ALPHA CHAIN; APOPTOSIS; ARTICLE; BINDING SITE; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT LECTIN PATHWAY; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HOST; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; TISSUE INJURY; CELL CULTURE; CHEMISTRY; GENETICS; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; BINDING SITES; C-REACTIVE PROTEIN; CALCIUM; CELLS, CULTURED; COMPLEMENT C4B-BINDING PROTEIN; EXTRACELLULAR MATRIX; HUMANS; JURKAT CELLS; PROTEIN BINDING; SERUM AMYLOID P-COMPONENT;

EID: 80051917349     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023991     Document Type: Article

References (49)

1. Breviario F, d'Aniello EM, Golay J, Peri G, Bottazzi B, et al. (1992) Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem 267: 22190-22197.
2. Lee GW, Lee TH, Vilcek J, (1993) TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol 150: 1804-1812.
3. Deban L, Jaillon S, Garlanda C, Bottazzi B, Mantovani A, (2011) Pentraxins in innate immunity: lessons from PTX3. Cell Tissue Res 343: 237-249.
4. Mantovani A, Garlanda C, Doni A, Bottazzi B, (2008) Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 28: 1-13.
5. Inforzato A, Rivieccio V, Morreale AP, Bastone A, Salustri A, et al. (2008) Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization. J Biol Chem 283: 10147-10161.
6. Inforzato A, Baldock C, Jowitt TA, Holmes DF, Lindstedt R, et al. (2010) The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2. J Biol Chem 23: 17681-17692.
7. Bottazzi B, Vouret-Craviari V, Bastone A, De Gioia L, Matteucci C, et al. (1997) Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem 272: 32817-32823.
8. Bottazzi B, Doni A, Garlanda C, Mantovani A, (2010) An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol 28: 157-183.
9. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, et al. (2002) Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 420: 182-186.
10. Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, et al. (2008) Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature 456: 989-992.
11. Moalli F, Doni A, Deban L, Zelante T, Zagarella S, et al. (2010) Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 116: 5170-5180.
12. Nauta AJ, Bottazzi B, Mantovani A, Salvatori G, Kishore U, et al. (2003) Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol 33: 465-473.
13. Ma YJ, Doni A, Hummelshøj T, Honoré C, Bastone A, et al. (2009) Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem 284: 28263-28275.
14. Walport MJ, (2001) Complement. First of two parts. N Engl J Med 344: 1058-1066.
15. Nauta AJ, Daha MR, van Kooten C, Roos A, (2003) Recognition and clearance of apoptotic cells: a role for complement and pentraxins. Trends Immunol 24: 148-154.
16. Hajishengallis G, Lambris JD, (2010) Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol 31: 154-163.
17. Volanakis JE, Kaplan MH, (1974) Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q. J Immunol 113: 9-17.
18. Ng PM, Le Saux A, Lee CM, Tan NS, Lu J, et al. (2007) C-reactive protein collaborates with plasma lectins to boost immune response against bacteria. EMBO J 26: 3431-3440.
19. Jarva H, Jokiranta TS, Hellwage J, Zipfel PF, Meri S, (1999) Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. J Immunol 163: 3957-3962.
20. Sjöberg AP, Trouw LA, McGrath FD, Hack CE, Blom AM, (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. J Immunol 176: 7612-7620.
21. Rodríguez de Córdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sánchez-Corral P, (2004) The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol 41: 355-367.
22. Blom AM, Villoutreix BO, Dahlbäck B, (2004) Complement inhibitor C4b-binding protein-friend or foe in the innate immune system? Mol Immunol 40: 1333-1346.
23. Sjöberg AP, Trouw LA, Blom AM, (2009) Complement activation and inhibition: a delicate balance. Trends Immunol 30: 83-90.
24. Webb JH, Blom AM, Dahlbäck B, (2002) Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells. J Immunol 169: 2580-2586.
25. Ma YJ, Doni A, Skjoedt MO, Honoré C, Arendrup M, et al. (2011) Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. J Biol Chem 286: 3405-3417.
26. Gout E, Moriscot C, Doni A, Dumestre-Pérard C, Lacroix M, et al. (2011) M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J Immunol 186: 5815-5822.
27. Deban L, Jarva H, Lehtinen MJ, Bottazzi B, Bastone A, et al. (2008) Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation. J Immunol 181: 8433-8440.
28. Kresl JJ, Potempa LA, Anderson BE, (1998) Conversion of native oligomeric to a modified monomeric form of human C-reactive protein. Int J Biochem Cell Biol 30: 1415-1426.
29. Bíró A, Rovó Z, Papp D, Cervenak L, Varga L, et al. (2007) Studies on the interactions between C-reactive protein and complement proteins. Immunology 121: 40-50.
30. Salustri A, Garlanda C, Hirsch E, De Acetis M, Maccagno A, et al. (2004) PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development 131: 1577-1586.
31. Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, et al. (2007) PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. J Biol Chem 282: 30161-30170.
32. Happonen KE, Sjöberg AP, Mörgelin M, Heinegård D, Blom AM, (2009) Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix. J Immunol 182: 1518-1525.
33. Rovere P, Peri G, Fazzini F, Bottazzi B, Doni A, et al. (2000) The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood 96: 4300-4306.
34. Trouw LA, Bengtsson AA, Gelderman KA, Dahlbäck B, Sturfelt G, et al. (2007) C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack. J Biol Chem 282: 28540-28548.
35. Kask L, Trouw LA, Dahlbäck B, Blom AM, (2004) The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells. J Biol Chem 279: 23869-23873.
36. Diniz SN, Nomizo R, Cisalpino PS, Teixeira MM, Brown GD, et al. (2004) PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. J Leukoc Biol 75: 649-656.
37. Jones J, Morgan BP, (1995) Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation. Immunology 86: 651-660.
38. Gershov D, Kim S, Brot N, Elkon KB, (2000) C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med 192: 1353-1364.
39. Hindmarsh EJ, Marks RM, (1998) Complement activation occurs on subendothelial extracellular matrix in vitro and is initiated by retraction or removal of overlying endothelial cells. J Immunol 160: 6128-6136.
40. Hindmarsh EJ, Marks RM, (1998) Decay-accelerating factor is a component of subendothelial extracellular matrix in vitro, and is augmented by activation of endothelial protein kinase C. Eur J Immunol 28: 1052-1062.
41. Jaillon S, Peri G, Delneste Y, Frémaux I, Doni A, et al. (2007) The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 204: 793-804.
42. Rolph MS, Zimmer S, Bottazzi B, Garlanda C, Mantovani A, et al. (2002) Production of the long pentraxin PTX3 in advanced atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22: e10-14.
43. Lee TH, Lee GW, Ziff EB, Vilcek J, (1990) Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts. Mol Cell Biol 10: 1982-1988.
44. Luchetti MM, Piccinini G, Mantovani A, Peri G, Matteucci C, et al. (2000) Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA). Clin Exp Immunol 119: 196-202.
45. Sjöberg A, Onnerfjord P, Mörgelin M, Heinegård D, Blom AM, (2005) The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem 280: 32301-32308.
46. Sjöberg AP, Manderson GA, Mörgelin M, Day AJ, Heinegård D, et al. (2009) Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol 46: 830-839.
47. Sjöberg AP, Nyström S, Hammarström P, Blom AM, (2008) Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly. Mol Immunol 45: 3213-3221.
48. Mihlan M, Stippa S, Józsi M, Zipfel PF, (2009) Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H. Cell Death Differ 16: 1630-1640.
49. Hebecker M, Okemefuna AI, Perkins SJ, Mihlan M, Huber-Lang M, et al. (2010) Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4. Mol Immunol 47: 1347-1355.