Alpha1-macroglobulin: A potential obesity-related factor in serum

Medical Science Monitor

Volumn 14, Issue 3, 2008, Pages

  Zhao, Dan ^a   Wang, Shu Ran ^a   Ma, Wei Wei ^b   Liu, Li Jie ^c   Sun, Chang Hao ^a,d  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c NORTHEAST FORESTRY UNIVERSITY   (China)

^d NONE   (China)

Author keywords

1 macroglobulin; Obesity proneness; Obesity resistance; Proteome; Two dimensional gel electrophoresis

Indexed keywords

ALPHA 1 MACROGLOBULIN; APOLIPOPROTEIN A1; BETA ACTIN; HAPTOGLOBIN; MACROGLOBULIN; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; LIPID DIET; MALE; MASS SPECTROMETRY; NONHUMAN; OBESITY; PEPTIDE ANALYSIS; PROTEIN FUNCTION; PROTEOMICS; RAT; SPRAGUE DAWLEY RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ALPHA-MACROGLOBULINS; ANIMALS; BODY COMPOSITION; DIETARY FATS; MALE; OBESITY; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; SERUM;

EID: 41449086800     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Formiguera X, Canton A: Obesity: epidemiology and clinical aspects. Best Pract Res Clin Gastroenterol, 2004; 18(6): 1125-46
2. Feng JT, Liu YK, Song HY et al: Heat-shock protein 27: a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis. Proteomics, 2005; 5(17): 4581-88
3. Swiatkowska-Stodulska R, Bakowska A, Drobińska-Jurowiecka A: Interleukin-8 in the blood serum of patients with alcoholic liver disease. Med Sci Monit, 2006; 12(5): CR215-20
4. Johnson PR, Zucker LM, Cruce JA et al: Cellularity of adipose depots in the genetically obese Zucker rat. J Lipid Res, 1971; 12(6): 706-14
5. Pelleymounter MA, Cullen MJ, Baker MB et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 1995; 269(5223): 540-43
6. Brown DF: Inhibition of gold thioglucose lesion formation in the ventromedial hypothalamus by a glucocorticoid. Physiol Behav, 1986; 37(3): 459-63
7. Parkinson WL, Weingarten HP: Dissociative analysis of ventromedial hypothalamic obesity syndrome. Am J Physiol, 1990; 259 (4 Pt 2): R829-35
8. Levin BE, Triscari J, Sullivan AC: Altered sympathetic activity during development of diet-induced obesity in rat. Am J Physiol, 1983; 244(3): R347-55
9. Levin BE, Triscari J, Sullivan AC: Relationship between sympathetic activity and diet-induced obesity in two rat strains. Am J Physiol, 1983; 245(3): R364-71
10. West DB, Waguespack J, McCollister S: Dietary obesity in the mouse: interaction of strain with dietary composition. Am J Physiol, 1995; 268(3 Pt 2): R658-65
11. Levin BE, Triscari J, Hogan S et al: Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin. Am J Physiol, 1987; 252(3 Pt 2): R471-78
12. Lauterio TJ, Perez FM: Growth hormone secretion and synthesis are depressed in obesity-susceptible compared to obesity-resistant rats. Metabolism, 1997; 46(2): 210-16
13. DeFronzo RA: Insulin secretion, insulin resistance, and obesity. Int J Obes, 1982; 6(Suppl.1): 73S-82
14. Stenel DJ, Lin FP, Ho TF et al: Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese and non-obese Singaporean boys. Int J Obes Relat Metab Disord, 2001; 25(7): 984-89
15. Johannsson G, Karlsson C, Lonn L et al: Serum leptin concentration and insulin sensitivity in men with abdominal obesity. Obes Res, 1998; 6(6): 416-21
16. Steppan CM, Bailey ST, Bhat S et al: The hormone resistin links obesity to diabetes. Nature, 2001; 409(6818): 307-12
17. Kantartzis K, Fritsche A, Tschritter O et al: The association between plasma adiponectin and insulin sensitivity in humans depends on obesity. Obes Res, 2005; 13(10): 1683-91
18. Tschop M, Weyer C, Tataranni PA et al: Circulating ghrelin levels are decreased in human obesity. Diabetes, 2001; 50(4): 707-9
19. Bełtowski J: Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity? Med Sci Monit, 2006; 12(6): RA112-19
20. Hayek T, Ito Y, Azrolan N et al: Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanistic studies in human Apo A-I transgenic and control mice. J Clin Invest, 1993; 91(4): 1665-71
21. Azrolan N, Odaka H, Breslow JL et al: Dietary fat elevates hepatic apoA-I production by increasing the fraction of apolipoprotein A-I mRNA in the translating pool. J Biol Chem, 1995; 270(34): 19833-38
22. Winder SJ, Ayscough KR: Actin-binding proteins. J Cell Sci, 2005; 18(Pt 4): 651-54
23. Lind SE, Smith DB, Janmey PA et al: Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Respir Dis, 1988; 138(2): 429-34
24. White P, Cooke N: The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab, 2000; 11(8): 320-27
25. Gomme PT, Bertolini J: Therapeutic potential of vitamin D-binding protein. Trends Biotechnol, 2004; 22(7): 340-45
26. Bergsma J, Boelen MK, Duursma AM et al: Complexes of rat alpha 1-macroglobulin and subtilisin are endocytosed by parenchymal liver cells. Biochem J, 1985; 226(1): 75-84
27. Eggertsen G, Hudson G, Shiels B et al: Sequence of rat alpha 1-macroglobulin, a broad-range proteinase inhibitor from the alpha-macroglobulin-complement family. Mol Biol Med, 1991; 8(2): 287-302
28. Kiorpes TC, Molica SJ, Wolf G: A plasma glycoprotein depressed in vitamin A deficiency in the rat: alpha 1-macroglobulin. J Nutr, 1976; 106(11): 1659-67
29. Xiao T, DeCamp DL, Spran SR: Structure of a rat alpha 1-macroglobulin receptor-binding domain dimmer. Protein Sci, 2000; 9(10): 1889-97
30. Gottschlich MM, Mayes T, Khoury JC et al: Significance of obesity on nutritional, immunologic, hormonal, and clinical outcome parameters in burns. J Am Diet Assoc, 1993; 93(11): 1261-68
31. Tungtrongchitr R, Pongpaew P, Vudhivai N et al: Relationship between alpha-2-macroglobulin, anthropometric parameters and lipid profiles in Thai overweight and obese in Bangkok. Nutr Res, 2003; 23: 1143-52