Altered intestinal motility in leptin-deficient obese mice

Journal of Surgical Research

Volumn 124, Issue 1, 2005, Pages 98-103

  Kiely, James M ^a   Noh, Jae H ^a   Graewin, Shannon J ^a   Pitt, Henry A ^a   Swartz Basile, Deborah A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cholecystokinin; Gastric emptying; Leptin; Ob ob mice; Obesity; Small intestinal motility; Transit time

Indexed keywords

ACETYLCHOLINE; CHOLECYSTOKININ; LEPTIN; NEUROTRANSMITTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DIET; FEEDING; FLUORESCENCE; GEOMETRY; ILEUM; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; JEJUNUM; LEAN BODY WEIGHT; LIQUID; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL; SMALL INTESTINE; STOMACH EMPTYING; TIME;

EID: 13944262932     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2004.10.005     Document Type: Article

References (25)

1. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425
2. J. Barrenetxe, A.C. Villaro, L. Guembe, I. Pascual, M. Munoz-Navas, A. Barber, M.P. Lostao Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes Gut 50 2002 797
3. J.M. Friedman, J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763
4. R.A. Hill, S. Margetic, G.G. Pegg, C. Gazzola Leptin Its pharmacokinetics and tissue distribution Int. J. Obes. Relat. Metab. Disord. 22 1998 765
5. L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G.J. Richards, L.A. Campfield, F.T. Clark, J. Deeds Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263
6. N.M. Morton, V. Emilsson, Y.L. Liu, M.A. Cawthorne Leptin action in intestinal cells J. Biol. Chem. 273 1998 26194
7. K. Alavi, M.Z. Schwartz, R. Prasad, D. O'Connor, V. Funanage Leptin A new growth factor for the small intestine J. Pediatr. Surg. 37 2002 327
8. P.Y. Pearson, D.M. O'Connor, M.Z. Schwartz Novel effect of leptin on intestinal adaptation J. Surg. Res. 97 2001 192
9. M.P. Losato, E. Urdaneta, E. Martinez-Anso, A. Barber, J.A. Martinez Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption FEBS Lett. 423 1998 302
10. M. Buyse, F. Berlioz, S. Guilmeau, A. Tsocas, T. Voisin, G. Peranzi, D. Merlin, M. Laburthe, M.J. Lewin, C. Roze, A. Bado PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine J. Clin. Invest. 108 2001 1483
11. M. Buyse, M.L. Ovesjo, H. Goiot, S. Guilmeau, G. Peranzi, L. Moizo, F. Walker, M.J. Lewin, B. Meister, A. Bado Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve Eur. J. Neurosci. 14 2001 64
12. S. Gaige, A. Abysique, M. Bouvier Effects of leptin on cat intestinal vagal mechanoreceptors J. Physiol. 543 2002 679
13. S. Gaige, A. Abysique, M. Bouvier Effects of leptin on cat intestinal motility J. Physiol. 546 2002 267
14. A. Asakawa, A. Inui, N. Ueno, S. Makino, M.A. Fujino, M. Kasuga Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice Gastroenterology 116 1999 1287
15. N.T. Schwarz, J.C. Kalff, A. Turler, N. Speidel, J.R. Grandis, T.R. Billiar, A.J. Bauer Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility Gastroenterology 126 2004 159
16. H.Y. Chang, H. Mashimo, R.K. Goyal Musings on the wanderer What's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut Am. J. Physiol. Gastrointest. Liver Physiol. 284 2003 G357
17. E. Jones, A. Symes Leptin and TGF-β synergistically regulate VIP cytokine response element transcription Mol. Neurosci. 11 2000 4049
18. M.I. Goldblatt, D.A. Swartz-Basile, C.L. Svatek, A. Nakeeb, H.A. Pitt Decreased gallbladder response in leptin-deficient obese mice J. Gastrointest. Surg. 6 2002 438
19. J. Phillips, K.Q. Tran, M.I. Goldblatt, D.A. Swartz-Basile, A. Nakeeb, H.A. Pitt Leptin ameliorates the gallbladder's response to neurotransmitters in congenitally obese mice Gastroenterology 123 Suppl. 2002 729
20. J. Morisset, L. Geoffrion, L. Larose, J. Lanoe, G.G. Poirier Distribution of muscarinic receptors in the digestive tract organs Pharmacology 22 1981 189
21. L.D. Scott, E. DeFlora, N.W. Weisbrodt, R. Lester Pregnancy, sex steroids, and contractility of rat small intestine Gastroenterology 82 1982 1174
22. J. Wolinski, V. Lesniewska, M. Biernat, M. Babelewska, W. Korczynski, R. Zabielski Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets-preliminary results J. Anim. Feed Sci. 10 2002 249
23. V. Martinez, M.D. Barrachina, L. Wang, Y. Tache Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats Neuroreport 10 1999 3217
24. M.D. Barrachina, V. Martinez, L. Wang, J.Y. Wei, Y. Tache Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice Proc. Natl. Acad. Sci. USA 94 1997 10455
25. S. Guilmeau, M. Buyse, A. Tsocas, J.P. Laigneau, A. Bado Duodenal leptin stimulates cholecystokinin secretion Evidence of a positive leptin- cholecystokinin feedback loop Diabetes 52 2003 1664