Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets

Blood

Volumn 88, Issue 3, 1996, Pages 907-914

  Wagner, Carrie L ^a   Mascelli, Mary A ^a   Neblock, Donald S ^a   Weisman, Harlan F ^a   Coller, Barry S ^a   Jordan, Robert E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN RECEPTOR; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IODINE 125; MONOCLONAL ANTIBODY;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PURIFICATION; RECEPTOR BINDING; RECEPTOR DENSITY; THROMBOCYTE;

EID: 0029763215     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.3.907.bloodjournal883907     Document Type: Article

References (37)

1. Phillips DR, Charo IF, Parise LV, Fitzgerald LA: The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831, 1988
2. Coller BS: Platelets in cardiovascular thrombosis and thrombolysis, in Fozzard HA (ed): The Heart and Cardiovascular System (ed 2). New York, NY, Raven, 1992, p 219
3. Bennett JS, Vilaire G: Exposure of platelet fibrinogen receptors by ADP or epinephrine. J Clin Invest 64:393, 1979
4. Marguerie GA, Edgington TS, Plow EF: Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-mediated platelet aggregation. J Biol Chem 255:154, 1980
5. Niiya K, Hodson E, Bader R, Byers-Ward V, Koziol JA, Plow EF, Ruggeri ZM: Increased surface expression of the membrane GPIIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation. Blood 70:475, 1987
6. Wencel-Drake JD. Frelinger AL, Dieter MG, Lam SC-T: Arg-Gly-Asp-dependent occupancy of GPIIb/IIIa by Applagin: Evidence for internalization and cycling of a platelet integrin. Blood 81:62, 1993
7. Savage B, Marzec U, Chao B, Harker L, Maraganore J, Ruggeri Z: Binding of the snake venom-derived proteins Applaggin and Echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb/IIIa complex inhibits receptor function. J Biol Chem 265:11766, 1990
8. Tsao P, Bozarth J, Jackson S, Forsythe M, Flint S, Mousa S: Platelet GPIIb/IIIa receptor occupancy studies using a novel fluoresceinated cyclic Arg-Gly-Asp peptide. Thrombosis Res 77:543, 1995
9. Newman PJ, Allen RW, Kahn RA, Kunicki TJ: Quantitation of membrane GPIIIa on intact human platelets using the monoclonal antibody, AP-3. Blood 65:227, 1985
10. Tomiyama Y, Tsubakio T, Piotrowicz RS, Kurata Y, Loftus JC, Kunicki TJ: The Arg-Gly-Asp (RGD) recognition site of platelet glycoprotein IIb-IIIa on nonactivated platelets is accessible to high-affinity macromolecules. Blood 79:2303, 1992
11. Pidard D, Montgomery RR, Bennett JS, Kunicki TJ: Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J Biol Chem 258:12582, 1983
12. McEver RP, Bennett EM, Martin MN: Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies. J Biol Chem 258:5269, 1983
13. Bennett JS. Hoxie JA, Leitman SF, Vilaire G, Cines DB: Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody. Proc Natl Acad Sci USA 80:2417, 1983
14. Ramsamooj P, Doellgast GJ, Hantgan RR: Inhibition of fibrin(ogen) binding to stimulated platelets by a monoclonal antibody specific for a conformational determinant of GPIIIa. Thromb Res 58:577, 1990
15. McEver RP, Baenziger NL, Majerus PW: Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest 66:1311, 1980
16. Coller BS, Peerschke EI, Scudder LE, Sullivan CA: A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa. J Clin Invest 73:325, 1983
17. Coller BS: A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest 76:101, 1985
18. Coller BS: Activation affects access to the platelet receptor for adhesive glycoproteins. J Cell Biol 103:451, 1986
19. Woods VL, Wolff LE, Keller DM: Resting platelets contain a substantial centrally located pool of GPIIb/IIIa complex which may be accessible to some but not other extracellular proteins. J Biol Chem 261:15242, 1986
20. Kutok JL, Coller BS: Partial inhibition of platelet aggregation and fibrinogen binding by a murine monoclonal antibody to GPIIIa: Requirement for antibody bivalency. Thromb Haemost 72:964, 1994
21. Knight DM, Wagner C, Jordan R, McAleer MF, Derita R, Pass DN, Coller BS, Weisman H, Ghrayeb J: Humanizing the constant region of the 7E3 murine monoclonal Fab antibody fragment reduces the immunogenicity of the variable region in humans. Mol Immunol 32:1271, 1995
22. Bast RC, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC: Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68:1331, 1981
23. Parham P: Preparation and purification of active fragments from mouse monoclonal antibodies, in Weir DM (ed): Handbook of Experimental Immunochemistry: Immunochemistry. London, UK, Blackwell Scientific, 1986 p 14.1
24. 2 antibody which inhibits platelet aggregation and localizes tissue plasminogen activator to the platelet surface. Bioconj Chem 3:126, 1992
25. Peterson GL: Determination of total protein. Methods Enzymol 91:95, 1983
26. Fraker DJ, Speck JC: Protein and cell membrane iodinations with a sparingly soluble chloroamide. 1,3,4,5-tetrachloro-3a,6a-diphenyl-glycoluril. Biochem Biophys Res Commun 80:849, 1978
27. Marguerie GA, Plow EF, Edgington TS: Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem 254:5357, 1979
28. Lombardo VT, Hodson E, Roberts JP, Kunicki TJ, Zimmerman TS, Ruggeri ZM: Independent modulation of von Willebrand factor and fibrinogen binding to platelet membrane GPIIb/IIIa. J Clin Invest 76:1950, 1985
29. Blum M, Jordan R, Wagner C, Mattis J: Immunopurification and functional characterization of platelet GPIIb/IIIa complexes. Blood 74:398a, 1989 (abstr no. 1521, suppl 1)
30. Cramer EM, Savidge GF, Vainchenker W, Berndt MC, Pidard D, Caen JP, Masse J-M, Breton-Gorius J: Alpha-granule pool of GPIIb-IIIa in normal and pathologic platelets and megakaiyocytes. Blood 75:1220, 1990
31. Escolar G, Leistikow E, White JG: The fate of the open canalicular system in surface and suspension-activated platelets. Blood 74:1983, 1989
32. Coller BS, Cheresh DA, Asch E, Seligsohn U: Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood 77:75, 1991
33. Coller BS: Biochemical and electrostatic considerations in primary platelet aggregation. Ann NY Acad Sci 416:693, 1983
34. Sosnick TR, Benjamin DC, Novotny J, Seeger PA, Trewhella J: Distances between the antigen-binding sites of three murine antibody subclasses measured using neutron and X-ray scattering. Biochemistry 31:1779, 1992
35. Kloczewiak M, Timmons S, Lukas TJ, Hawiger J: Platelets receptor recognition site on human fibrinogen: synthesis and structure-function relationship of peptides corresponding to the carboxylterminal segment of the gamma chain. Biochemistry 23:1767, 1984
36. Farrell DH, Thiagarajan P, Chung DW, Davie EW: Role of fibrinogen α and γ chain sites in platelet aggregation. Proc Natl Acad Sci USA 89:10729, 1992
37. Weisel JW, Nagaswami C, Vilaire G, Bennett JS: Examination of the platelet membrane GPIIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy. J Biol Chem 267:16637, 1992