Evaluation of protein stability and in vitro permeation of lyophilized polysaccharides-based microparticles for intranasal protein delivery

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 77-84

  Cho, Hyun Jong ^a   Balakrishnan, Prabagar ^a   Chung, Suk Jae ^a   Shim, Chang Koo ^a   Kim, Dae Duk ^a  

^a Seoul National University   (South Korea)

Author keywords

Intranasal delivery; Lyophilized microparticle; Lysozyme; Permeation enhancer; Protein stability; TPGS

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CHITOSAN DERIVATIVE; CRYOPROTECTIVE AGENT; DEXTRO ALPHA TOCOPHERYL POLY(ETHYLENE GLYCOL 1000) SUCCINATE; HYDROXYPROPYLMETHYLCELLULOSE; LYSOZYME; MACROGOL 10000; POLYMER; UNCLASSIFIED DRUG; WATER SOLUBLE CHITOSAN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; FEASIBILITY STUDY; FREEZE DRYING; IN VITRO STUDY; NOSE MUCOSA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STABILITY;

ABSORPTION; ADMINISTRATION, INTRANASAL; BETA-CYCLODEXTRINS; CHITOSAN; FREEZE DRYING; HUMANS; METHYLCELLULOSE; MURAMIDASE; NASAL MUCOSA; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POWDERS; PRIMARY CELL CULTURE; PROTEIN STABILITY; SUCCINATES; VITAMIN E;

EID: 80051801624     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.009     Document Type: Article

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