Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride

European Journal of Pharmaceutical Sciences

Volumn 40, Issue 1, 2010, Pages 9-15

  Huh, Yeamin ^a   Cho, Hyun Jong ^a   Yoon, In Soo ^a   Choi, Min Koo ^a,b   Kim, Jung Sun ^c   Oh, Euichaul ^d   Chung, Suk Jae ^a   Shim, Chang Koo ^a,b   Kim, Dae Duk ^a  

^a Seoul National University   (South Korea)

^b Inje University   (South Korea)

^c Dongseo University   (South Korea)

^d STH Pharm Inc   (South Korea)

Author keywords

Fexofenadine HCl; Hyaluronic acid; Nasal delivery; Spray dried microsphere

Indexed keywords

FEXOFENADINE; HYALURONIC ACID; MACROGOL 6000; MICROSPHERE; TAUROCHOLIC ACID; ANTIALLERGIC AGENT; DRUG CARRIER; MACROGOL DERIVATIVE; TERFENADINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL CULTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG PENETRATION; DRUG SOLUBILITY; EXPERIMENTAL RABBIT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MONOLAYER CULTURE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; IMPEDANCE; INTRANASAL DRUG ADMINISTRATION; METABOLISM; PERMEABILITY; RABBIT; RESPIRATORY TRACT MUCOSA; SURFACE PROPERTY; SYNTHESIS;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTI-ALLERGIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CELL LINE; DRUG CARRIERS; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; HUMANS; HYALURONIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PERMEABILITY; POLYETHYLENE GLYCOLS; RABBITS; RESPIRATORY MUCOSA; SURFACE PROPERTIES; TAUROCHOLIC ACID; TERFENADINE;

EID: 77951207272     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.02.002     Document Type: Article

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