Cyclodextrins - Useful excipients for oral peptide administration?

International Journal of Pharmaceutics

Volumn 137, Issue 1, 1996, Pages 103-110

  Haeberlin, Barbara ^a   Gengenbacher, Thomas ^a   Meinzer, Armin ^a   Fricker, Gert ^a,b  

^a Sandoz Pharma Ltd   (Switzerland)

^b Inst F Pharmazeut Technol B   (Germany)

Author keywords

Calcitonin; Cyclodextrins; Octreotide; Oral peptide delivery; Tight junctions

Indexed keywords

ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; CALCITONIN; CYCLODEXTRIN DERIVATIVE; GAMMA CYCLODEXTRIN; MACROGOL 4000; OCTREOTIDE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030596496     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04499-7     Document Type: Article

References (12)

1. Brewster, M.E., Hora, M.S., Simpkins, J.W. and Bodor, N., Use of 2-hydroxypropyl-β-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs. Pharm. Res., 8 (1991) 792-795.
2. Drewe, J., Fricker, G., Vonderscher, J. and Beglinger, C., Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether. Br. J. Pharmacol., 108 (1993) 298-303.
3. Fricker, G. and Drewe. J., Enteral absorption of octreotide. Modulation of permeability by distinct carbohydrates. J. Pharmacol. Exp. Ther., 274 (1995) 826-832.
4. Fricker, G., Bruns, C., Munzer, J., Briner, U., Albert, R., Kissel, T. and Vonderscher, J., Intestinal absorption of the octapeptide octreotide 201-995 visualized by fluorescence derivatization. Gastroenterology, 100 (1991) 1544-1552.
5. Fricker, G., Drewe, J., Vonderscher, J., Kissel, T. and Beglinger, C., Enteral absorption of octreotide. Br. J. Pharmacol., 105 (1992) 783-786.
6. Irie, T., Otagiri, M., Sunada, M., Uekama, K., Ohtani, Y., Yamada, Y. and Sugiyama, Y., Cyclodextrin induced hemolysis and shape changes of human erythrocytes in vitro. J. Pharm. Dyn., 5 (1982) 741-744.
7. Irie, T., Wakamatsu, K., Arima, H., Aritomi, H. and Uekama, K., Enhancing effects of cyclodextrins on nasal absorption of insulin in rats. Int. J. Pharm., 84 (1992) 129-139.
8. Saenger, W., Cyclodextrin inclusion compounds in research and industry. Angew. Chem. Int. Ed. Engl., 19 (1980) 344-362.
9. Shao, Z., Krishnamoorthy, R. and Mitra, A.Z., Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluation. Pharm. Res., 9 (1992) 1157-1163.
10. Szejtli, J., Chemistry, characterization and properties of cyclodextrins. In Breimer, D.D. and Speiser, P. (Eds.), Topics in Pharmaceutical Sciences. 1987, 151 pp.
11. Szejtli, J., Bolla-Pusztei, E. and Kajatar, M., The β-cyclodextrin inclusion complex of menadione (vitamin K3). Pharmazie, 37 (1982) 725-728.
12. Uekama, K., Narisawa, S., Hirayama, F. and Otagiri, M., Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation. Int. J. Pharm., 16 (1983) 327-338.