Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment

Leukemia

Volumn 25, Issue 8, 2011, Pages 1305-1313

  Eckert, C ^a   Flohr, T ^b   Koehler, R ^b   Hagedorn, N ^a   Moericke, A ^c   Stanulla, M ^c   Kirschner Schwabe, R ^a   Cario, G ^c   Stackelberg, Av ^a   Bartram, C R ^b   Henze, G ^a   Schrappe, M ^c   Schrauder, A ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

childhood ALL; clonality; early relapses; MRD; TCR IG markers

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN; PREDNISONE; T LYMPHOCYTE RECEPTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RELAPSE; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CLONAL VARIATION; DISEASE MARKER; FEMALE; GENE REARRANGEMENT; GENETIC HETEROGENEITY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; MALE; MINIMAL RESIDUAL DISEASE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT RESPONSE;

CHILD; CHILD, PRESCHOOL; FEMALE; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HUMANS; MALE; NEOPLASM, RESIDUAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROSPECTIVE STUDIES; RECEPTORS, ANTIGEN, T-CELL; RECURRENCE;

EID: 80051783672     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.89     Document Type: Article

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