메뉴 건너뛰기




Volumn 9, Issue 5, 2011, Pages 629-646

Systemic adverse drug reactions secondary to anti-VEGF intravitreal injection in patients with neovascular age-related macular degeneration

Author keywords

Age related macular degeneration; Anti VEGF; Bevacizumab; Bleeding; Hypertension; Pegaptanib; Proteinuria; Ranibizumab; Side effects; Stroke

Indexed keywords

AFLIBERCEPT; AL 39324; BEVACIZUMAB; BEVASIRANIB; FLUOROURACIL; PAZOPANIB; PEGAPTANIB; PROTEIN TYROSINE KINASE INHIBITOR; RANIBIZUMAB; TG 100801; TG 101095; UNCLASSIFIED DRUG; VASCULOTROPIN; VATALANIB; VERTEPORFIN;

EID: 80051778087     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016111796642670     Document Type: Article
Times cited : (34)

References (213)
  • 1
    • 11144354339 scopus 로고    scopus 로고
    • Eye Diseases Preva lence Research Group. Prevalence of age-related macular degenera tion in the United States
    • Friedman DS, O'Colmain BJ, Muñoz B, et al. Eye Diseases Preva lence Research Group. Prevalence of age-related macular degenera tion in the United States. Arch Ophthalmol 2004; 22: 564-572.
    • (2004) Arch Ophthalmol , vol.22 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Muñoz, B.3
  • 2
    • 1542297335 scopus 로고    scopus 로고
    • The epidemiology of age-related macular degeneration
    • Klein R, Peto T, Bird A, Vannewkirk MR. The epidemiology of age-related macular degeneration. Am J Ophthalm 2004; 137: 486-495.
    • (2004) Am J Ophthalm , vol.137 , pp. 486-495
    • Klein, R.1    Peto, T.2    Bird, A.3    Vannewkirk, M.R.4
  • 3
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2004; 9: 669-676.
    • (2004) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 4
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219: 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 5
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1981; 161: 851-858.
    • (1981) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 6
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal disease
    • Michaelson IC. The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal disease. Trans Ophthalmol Soc UK 1948; 68: 137-180.
    • (1948) Trans Ophthalmol Soc UK , vol.68 , pp. 137-180
    • Michaelson, I.C.1
  • 7
    • 0017912754 scopus 로고
    • Photocoagulation treatment of proliferative diabetic retinopathy: The second report of Diabetic Retinopathy Study findings
    • The Diabetic Retinopathy Study Research Group
    • The Diabetic Retinopathy Study Research Group: Photocoagulation treatment of proliferative diabetic retinopathy: the second report of Diabetic Retinopathy Study findings. Ophthalmology 1978; 85: 82-106.
    • (1978) Ophthalmology , vol.85 , pp. 82-106
  • 8
    • 0022645069 scopus 로고
    • Argon laser scatter photoco-agulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion
    • Branch Vein Occlusion Study Group
    • Branch Vein Occlusion Study Group: Argon laser scatter photoco-agulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion. Arch Ophthalmol 1986; 104: 34-41.
    • (1986) Arch Ophthalmol , vol.104 , pp. 34-41
  • 9
    • 84855701175 scopus 로고    scopus 로고
    • th Edition. Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP (Eds.), Elsevier, London, UK
    • th Edition. Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP (Eds.), Elsevier, London, UK 2006: 1240-1270.
    • (2006) Etiologic Mechanisms In Diabetic Retinopathy , pp. 1240-1270
    • Frank, R.N.1
  • 10
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3
  • 11
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck PJ, Hauser SD, Krivi, G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309-1312.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3
  • 12
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/ VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/ VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 2005; 109: 227-241.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 13
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithe-lial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithe-lial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993; 4: 1317-1326.
    • (1993) Mol Biol Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 15
    • 22344437713 scopus 로고    scopus 로고
    • Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    • Lee S, Jilani SM, Nikolova GV, et al. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 2005; 169: 681-691.
    • (2005) J Cell Biol , vol.169 , pp. 681-691
    • Lee, S.1    Jilani, S.M.2    Nikolova, G.V.3
  • 16
    • 0034923623 scopus 로고    scopus 로고
    • Extracellular proteolysis and angiogenesis
    • Pepper MS. Extracellular proteolysis and angiogenesis. Thromb Haemost 2001; 86: 346-355.
    • (2001) Thromb Haemost , vol.86 , pp. 346-355
    • Pepper, M.S.1
  • 17
    • 13144266696 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    • Olofsson B, Korpelainen E, Pepper MS, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 1998; 95: 11709-11714.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11709-11714
    • Olofsson, B.1    Korpelainen, E.2    Pepper, M.S.3
  • 18
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier, G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435-439.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 19
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family
    • Shibuya M, Yamaguchi S, Yamane A, et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family. Oncogene 1990; 8: 519-527.
    • (1990) Oncogene , vol.8 , pp. 519-527
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3
  • 20
    • 0026699255 scopus 로고
    • FLT4 receptor tyro-sine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • Pajusola K, Aprelikova O, Korhonen J, et al. FLT4 receptor tyro-sine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 1992; 52: 5738-5743.
    • (1992) Cancer Res , vol.52 , pp. 5738-5743
    • Pajusola, K.1    Aprelikova, O.2    Korhonen, J.3
  • 21
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentia-tion of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park JE, Chen HH, Winer J, et al. Placenta growth factor. Potentia-tion of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 1994; 269: 25646-25654.
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3
  • 22
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 23
    • 18344391843 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in threedimensional collagen gels
    • Bauer SM, Bauer RJ, Liu ZJ, et al. Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in threedimensional collagen gels. J Vasc Surg 2005; 41: 699-707.
    • (2005) J Vasc Surg , vol.41 , pp. 699-707
    • Bauer, S.M.1    Bauer, R.J.2    Liu, Z.J.3
  • 24
    • 0033521040 scopus 로고    scopus 로고
    • Placenta growth factor and vascular endothelial growth factor B and C expression in microvas-cular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis
    • Yonekura H, Sakurai S, Liu X, et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvas-cular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem 1999; 274: 35172-35178.
    • (1999) J Biol Chem , vol.274 , pp. 35172-35178
    • Yonekura, H.1    Sakurai, S.2    Liu, X.3
  • 25
    • 0035126049 scopus 로고    scopus 로고
    • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    • Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001; 7: 186-191.
    • (2001) Nat Med , vol.7 , pp. 186-191
    • Stacker, S.A.1    Caesar, C.2    Baldwin, M.E.3
  • 26
    • 0024461206 scopus 로고
    • Tumor vascular permeability factor stimulates endothelial cell growth and angio-genesis
    • Connolly DT, Heuvelman DM, Nelson R, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angio-genesis. J Clin Invest 1989; 84: 1470-1478.
    • (1989) J Clin Invest , vol.84 , pp. 1470-1478
    • Connolly, D.T.1    Heuvelman, D.M.2    Nelson, R.3
  • 27
    • 0030041561 scopus 로고    scopus 로고
    • Vascular endothe-lial growth factor localization in human ovary and fallopian tubes: Possible role in reproductive function and ovarian cyst formation
    • Gordon JD, Mesiano S, Zaloudek CJ, Jaffe RB. Vascular endothe-lial growth factor localization in human ovary and fallopian tubes: possible role in reproductive function and ovarian cyst formation. J Clin Endocrinol Metab 1996; 81: 353-359.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 353-359
    • Gordon, J.D.1    Mesiano, S.2    Zaloudek, C.J.3    Jaffe, R.B.4
  • 28
    • 33645732615 scopus 로고    scopus 로고
    • Remodeling after stroke
    • Zlokovic BV. Remodeling after stroke. Nat Med 2006; 12: 390-391.
    • (2006) Nat Med , vol.12 , pp. 390-391
    • Zlokovic, B.V.1
  • 29
    • 34548473120 scopus 로고    scopus 로고
    • Expression of vascular endothe-lial growth factor and receptor tyrosine kinases in cardiac ische-mia/reperfusion injury
    • Infanger M, Faramarzi S, Grosse J. Expression of vascular endothe-lial growth factor and receptor tyrosine kinases in cardiac ische-mia/reperfusion injury. Cardiovasc Pathol 2007; 16: 291-299.
    • (2007) Cardiovasc Pathol , vol.16 , pp. 291-299
    • Infanger, M.1    Faramarzi, S.2    Grosse, J.3
  • 30
    • 0036933570 scopus 로고    scopus 로고
    • Serum and plasma levels of FGF-2 and VEGF in healthy blood donors
    • Larsson A, Sköldenberg E, Ericson, H. Serum and plasma levels of FGF-2 and VEGF in healthy blood donors. Angiogenesis 2002; 5: 107-110.
    • (2002) Angiogenesis , vol.5 , pp. 107-110
    • Larsson, A.1    Sköldenberg, E.2    Ericson, H.3
  • 31
    • 0036985699 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
    • Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol 2002; 29: 10-14.
    • (2002) Semin Oncol , vol.29 , pp. 10-14
    • Ferrara, N.1
  • 32
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1: 1024-1028.
    • (1995) Nat Med , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3
  • 33
    • 0000615805 scopus 로고    scopus 로고
    • VEGF regulates endo-thelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber HP, McMurtrey A, Kowalski J, et al. VEGF regulates endo-thelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 1998; 273: 30366-30443.
    • (1998) J Biol Chem , vol.273 , pp. 30366-30443
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3
  • 34
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999; 103: 159-165.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 35
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA 1996; 93: 14765-14770.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 36
    • 32944474182 scopus 로고    scopus 로고
    • VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    • Kamba T, Tam BY, Hashizume H, et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 2006; 290: 560-576.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , pp. 560-576
    • Kamba, T.1    Tam, B.Y.2    Hashizume, H.3
  • 37
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004; 165: 35-52.
    • (2004) Am J Pathol , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3
  • 38
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 39
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-4380.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 40
    • 80051726427 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts WG, Palade GE. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res 1999; 59: 4129-4135.
    • (1999) Cancer Res , vol.59 , pp. 4129-4135
    • Roberts, W.G.1    Palade, G.E.2
  • 41
    • 0033567094 scopus 로고    scopus 로고
    • Augmentation of transvascular transport of macromolecules and nanoparticles in tu-mor using endothelial growth factor
    • Monsky WL, Fukumura D, Gohongi T, et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tu-mor using endothelial growth factor. Cancer Res 1999; 59: 4129-4135.
    • (1999) Cancer Res , vol.59 , pp. 4129-4135
    • Monsky, W.L.1    Fukumura, D.2    Gohongi, T.3
  • 42
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • Jin K, Zhu Y, Sun Y, Mao XO, Xie L, Greenberg DA. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 2002; 99: 11946-11950.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11946-11950
    • Jin, K.1    Zhu, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5    Greenberg, D.A.6
  • 43
    • 2342667384 scopus 로고    scopus 로고
    • New roles for VEGF in nervous tissue beyond blood vessels
    • Rosenstein JM, Krum JM. New roles for VEGF in nervous tissue beyond blood vessels. Exp Neurol 2004; 187: 246-253.
    • (2004) Exp Neurol , vol.187 , pp. 246-253
    • Rosenstein, J.M.1    Krum, J.M.2
  • 44
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothe-lial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marmè D. Migration of human monocytes in response to vascular endothe-lial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996; 87: 3336-3343.
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marmè, D.6
  • 45
    • 4644344753 scopus 로고    scopus 로고
    • Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene. Invest
    • Martin AC, Thornton JD, Liu J, et al. Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene. Invest. Ophthalmol Vis Sci 2004; 45: 3387-3396.
    • (2004) Ophthalmol Vis Sci , vol.45 , pp. 3387-3396
    • Martin, A.C.1    Thornton, J.D.2    Liu, J.3
  • 46
    • 27544442148 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function
    • Marneros AG, Fan J, Yokoyama Y, et al. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol 2005; 167: 1451-1459.
    • (2005) Am J Pathol , vol.167 , pp. 1451-1459
    • Marneros, A.G.1    Fan, J.2    Yokoyama, Y.3
  • 47
    • 0029074024 scopus 로고
    • Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
    • Stone J, Itin A, Alon T, et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 1995; 15: 4738-4747.
    • (1995) J Neurosci , vol.15 , pp. 4738-4747
    • Stone, J.1    Itin, A.2    Alon, T.3
  • 48
    • 0037815292 scopus 로고    scopus 로고
    • VEGF guides angio-genic sprouting utilizing endothelial tip cell filopodia
    • Gerhardt H, Golding M, Fruttiger M, et al. VEGF guides angio-genic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003; 161: 1163-1177.
    • (2003) J Cell Biol , vol.161 , pp. 1163-1177
    • Gerhardt, H.1    Golding, M.2    Fruttiger, M.3
  • 49
    • 9144233038 scopus 로고    scopus 로고
    • VEGF and KDR gene expression during human embryonic and fetal eye development
    • Gogat K, Le Gat L, van den Berghe L, et al. VEGF and KDR gene expression during human embryonic and fetal eye development. Invest Ophthalmol Vis Sci 2004; 45: 7-14.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 7-14
    • Gogat, K.1    Le Gat, L.2    van den Berghe, L.3
  • 50
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran M, Kaelin WJ Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003; 111: 779-783.
    • (2003) J Clin Invest , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.J.2
  • 51
    • 33845251640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor biology: Clinical implications for ocular treatments
    • Bhisitkul RB. Vascular endothelial growth factor biology: clinical implications for ocular treatments. Br J Ophthalmol 2006; 90: 1542-1547.
    • (2006) Br J Ophthalmol , vol.90 , pp. 1542-1547
    • Bhisitkul, R.B.1
  • 52
    • 0032807809 scopus 로고    scopus 로고
    • Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation
    • Blaauwgeers HG, Holtkamp GM, Rutten H, et al. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Am J Pathol 1999; 155: 421-428.
    • (1999) Am J Pathol , vol.155 , pp. 421-428
    • Blaauwgeers, H.G.1    Holtkamp, G.M.2    Rutten, H.3
  • 53
    • 0032818006 scopus 로고    scopus 로고
    • Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes
    • Kim I, Ryan AM, Rohan R, et al. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes. Invest Ophthal-mol Vis Sci 1999; 40: 2115-2121.
    • (1999) Invest Ophthal-mol Vis Sci , vol.40 , pp. 2115-2121
    • Kim, I.1    Ryan, A.M.2    Rohan, R.3
  • 54
    • 0028145249 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model
    • Miller JW, Adamis AP, Shima DT, et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 1994; 145: 574-584.
    • (1994) Am J Pathol , vol.145 , pp. 574-584
    • Miller, J.W.1    Adamis, A.P.2    Shima, D.T.3
  • 55
    • 0029816808 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity
    • Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 1996; 114: 1219-1228.
    • (1996) Arch Ophthalmol , vol.114 , pp. 1219-1228
    • Pierce, E.A.1    Foley, E.D.2    Smith, L.E.3
  • 56
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-1487.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 57
    • 0027962667 scopus 로고
    • Detectionof vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze F, Clemens S, Simorer-Pinotel V, et al. Detectionof vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol 1994; 112: 1476-1482.
    • (1994) Arch Ophthalmol , vol.112 , pp. 1476-1482
    • Malecaze, F.1    Clemens, S.2    Simorer-Pinotel, V.3
  • 58
    • 0029171581 scopus 로고
    • Hypoxic induction of endo-thelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the sole mitogen
    • Shima D, Adamis AP, Ferrara N, et al. Hypoxic induction of endo-thelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the sole mitogen. Mol Med 1995; 2: 182-193.
    • (1995) Mol Med , vol.2 , pp. 182-193
    • Shima, D.1    Adamis, A.P.2    Ferrara, N.3
  • 59
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 1995; 92: 10457-10461.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 60
    • 0030067257 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a non-human primate
    • Adamis AP, Shima DT, Tolentino MJ, et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a non-human primate. Arch Ophthalmol 1996; 114: 66-71.
    • (1996) Arch Ophthalmol , vol.114 , pp. 66-71
    • Adamis, A.P.1    Shima, D.T.2    Tolentino, M.J.3
  • 61
    • 0030013610 scopus 로고    scopus 로고
    • Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
    • Robinson GS, Pierce EA, Rook SL, et al. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 1996; 93: 4851-4856.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4851-4856
    • Robinson, G.S.1    Pierce, E.A.2    Rook, S.L.3
  • 62
    • 0033882794 scopus 로고    scopus 로고
    • Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularisation
    • Ozaki H, Seo MS, Ozaki K, et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularisation. Am J Pathol 2000: 156: 697-707.
    • (2000) Am J Pathol , vol.156 , pp. 697-707
    • Ozaki, H.1    Seo, M.S.2    Ozaki, K.3
  • 63
    • 0030758411 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
    • Aiello LP. Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies. Ophthalmic Res 1997; 29: 354-362.
    • (1997) Ophthalmic Res , vol.29 , pp. 354-362
    • Aiello, L.P.1
  • 64
    • 0029935043 scopus 로고    scopus 로고
    • Levels of vascular endothe-lial growth factor are elevated in the vitreous of patients with subretinal neovascularisation
    • Wells JA, Murthy R, Chibber R, et al. Levels of vascular endothe-lial growth factor are elevated in the vitreous of patients with subretinal neovascularisation. Br J Ophthalmol 1996; 80: 363-366.
    • (1996) Br J Ophthalmol , vol.80 , pp. 363-366
    • Wells, J.A.1    Murthy, R.2    Chibber, R.3
  • 65
    • 0030844479 scopus 로고    scopus 로고
    • Transgenic mice with increased expression of vascular endothelial growth factor in the retina: A new model of intraretinal and subretinal neovascularisation
    • Okamoto N, Tobe T, Hackett SF, et al. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularisation. Am J Pathol 1997; 151: 281-291.
    • (1997) Am J Pathol , vol.151 , pp. 281-291
    • Okamoto, N.1    Tobe, T.2    Hackett, S.F.3
  • 66
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endo-thelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
    • Lopez PF, Sippy BD, Lambert HM, et al. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endo-thelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Oph-thalmol Vis Sci 1996; 37: 855-868.
    • (1996) Invest Oph-thalmol Vis Sci , vol.37 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3
  • 67
    • 0029758823 scopus 로고    scopus 로고
    • Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes
    • Frank RN, Amin RH, Eliott D, et al. Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol 1996; 122: 393-403.
    • (1996) Am J Ophthalmol , vol.122 , pp. 393-403
    • Frank, R.N.1    Amin, R.H.2    Eliott, D.3
  • 68
    • 0029831672 scopus 로고    scopus 로고
    • Subfoveal fibrovas-cular membranes in age-related macular degeneration express vascular endothelial growth factor
    • Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovas-cular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest Ophthalmol Vis Sci 1996; 37: 1929-1934.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 1929-1934
    • Kvanta, A.1    Algvere, P.V.2    Berglin, L.3    Seregard, S.4
  • 69
    • 0031050126 scopus 로고    scopus 로고
    • Increased expression of angiogenic growth factors in age-related maculopathy
    • Kliffen M, Sharma HS, Mooy CM, et al. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Oph-thalmol 1997; 8: 154-162.
    • (1997) Br J Oph-thalmol , vol.8 , pp. 154-162
    • Kliffen, M.1    Sharma, H.S.2    Mooy, C.M.3
  • 70
    • 0033882695 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularisation
    • Spilsbury K, Garrett KL, Shen WY, et al. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularisation. Am J Pathol 2000; 157: 135-144.
    • (2000) Am J Pathol , vol.157 , pp. 135-144
    • Spilsbury, K.1    Garrett, K.L.2    Shen, W.Y.3
  • 72
    • 0031870786 scopus 로고    scopus 로고
    • Vascular endothe-lial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
    • Lamoreaux WJ, Fitzgerald ME, Reiner A, et al. Vascular endothe-lial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res 1998; 55: 29-42.
    • (1998) Microvasc Res , vol.55 , pp. 29-42
    • Lamoreaux, W.J.1    Fitzgerald, M.E.2    Reiner, A.3
  • 73
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, et al. Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 74
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 75
    • 35548983950 scopus 로고    scopus 로고
    • Bevacizumab: Off-label use in ophthalmology
    • Grisanti S, Ziemssen F. Bevacizumab: off-label use in ophthalmology. Indian J Ophthalmol 2007; 55: 417-420.
    • (2007) Indian J Ophthalmol , vol.55 , pp. 417-420
    • Grisanti, S.1    Ziemssen, F.2
  • 76
    • 23044505200 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration
    • Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005; 36: 331-335.
    • (2005) Ophthalmic Surg Lasers Imaging , vol.36 , pp. 331-335
    • Rosenfeld, P.J.1    Moshfeghi, A.A.2    Puliafito, C.A.3
  • 77
    • 33745782355 scopus 로고    scopus 로고
    • Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration
    • Rich RM, Rosenfeld PJ, Puliafito CA, et al. Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2006; 26: 495-511.
    • (2006) Retina , vol.26 , pp. 495-511
    • Rich, R.M.1    Rosenfeld, P.J.2    Puliafito, C.A.3
  • 78
    • 33845750072 scopus 로고    scopus 로고
    • Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration
    • Yoganathan P, Deramo VA, Lai JC, et al. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina 2006; 26: 994-998.
    • (2006) Retina , vol.26 , pp. 994-998
    • Yoganathan, P.1    Deramo, V.A.2    Lai, J.C.3
  • 80
    • 34247238315 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for refractory pigment epithelial detachment with occult choroidal neovascu-larization in age-related macular degeneration
    • Chen E, Kaiser RS, Vander JF. Intravitreal bevacizumab for refractory pigment epithelial detachment with occult choroidal neovascu-larization in age-related macular degeneration. Retina 2007; 27: 445-450.
    • (2007) Retina , vol.27 , pp. 445-450
    • Chen, E.1    Kaiser, R.S.2    Vander, J.F.3
  • 81
  • 82
    • 33847159869 scopus 로고    scopus 로고
    • Intravitreal bevacizu-mab for exudative age-related macular degeneration after multiple treatments
    • Aggio FB, Farah ME, Silva WC, Melo GB. Intravitreal bevacizu-mab for exudative age-related macular degeneration after multiple treatments. Graefes Arch Clin Exp Ophthalmol 2007; 245: 215-220.
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , pp. 215-220
    • Aggio, F.B.1    Farah, M.E.2    Silva, W.C.3    Melo, G.B.4
  • 83
    • 34547403017 scopus 로고    scopus 로고
    • Visual acuity change after intravitreal bevacizumab for exudative age-related macular degeneration in relation to subfoveal membrane type
    • Jonas JB, Libondi T, Ihloff AK, et al. Visual acuity change after intravitreal bevacizumab for exudative age-related macular degeneration in relation to subfoveal membrane type. Acta Ophthalmol Scand 2007; 85: 563-565.
    • (2007) Acta Ophthalmol Scand , vol.85 , pp. 563-565
    • Jonas, J.B.1    Libondi, T.2    Ihloff, A.K.3
  • 84
    • 48449085770 scopus 로고    scopus 로고
    • A prospective study on intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration of different durations
    • Algvere PV, Steen B, Seregard S, Kvanta A. A prospective study on intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration of different durations. Acta Ophthalmol 2008; 86: 482-489.
    • (2008) Acta Ophthalmol , vol.86 , pp. 482-489
    • Algvere, P.V.1    Steen, B.2    Seregard, S.3    Kvanta, A.4
  • 85
    • 33847196122 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration: A short-term study
    • Chen CY, Wong TY, Heriot WJ. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration: a short-term study. Am. J Ophthalmol 2007; 143: 510-512.
    • (2007) Am. J Ophthalmol , vol.143 , pp. 510-512
    • Chen, C.Y.1    Wong, T.Y.2    Heriot, W.J.3
  • 86
    • 41549158189 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for subfoveal choroidal neovascularization secondary to age-related macular degeneration in an Indian population
    • Azad RV, Khan MA, Chanana B, Azad S. Intravitreal bevacizumab for subfoveal choroidal neovascularization secondary to age-related macular degeneration in an Indian population. Jpn J Ophthalmol 2008; 52: 52-56.
    • (2008) Jpn J Ophthalmol , vol.52 , pp. 52-56
    • Azad, R.V.1    Khan, M.A.2    Chanana, B.3    Azad, S.4
  • 87
    • 40549135324 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (A-vastin) therapy vs. photodynamic therapy plus intravitreal triamci-nolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomised, controlled clinical study
    • Weigert G, Michels S, Sacu S, et al. Intravitreal bevacizumab (A-vastin) therapy vs. photodynamic therapy plus intravitreal triamci-nolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomised, controlled clinical study. Br J Ophthalmol 2008; 92: 356-360.
    • (2008) Br J Ophthalmol , vol.92 , pp. 356-360
    • Weigert, G.1    Michels, S.2    Sacu, S.3
  • 88
    • 67651085336 scopus 로고    scopus 로고
    • Changes in neovascular choroidal morphology after intravitreal bevacizumab injection: Prospective trial on 156 eyes throughout 12-month follow-up
    • Costagliola C, Semeraro F, Cipollone U, Rinaldi M, della Corte M, Romano MR. Changes in neovascular choroidal morphology after intravitreal bevacizumab injection: prospective trial on 156 eyes throughout 12-month follow-up. Graefes Arch Clin Exp Ophthal-mol 2009; 247: 1031-1037.
    • (2009) Graefes Arch Clin Exp Ophthal-mol , vol.247 , pp. 1031-1037
    • Costagliola, C.1    Semeraro, F.2    Cipollone, U.3    Rinaldi, M.4    della Corte, M.5    Romano, M.R.6
  • 89
    • 70350141503 scopus 로고    scopus 로고
    • Intravitreal bevacizu-mab for treatment-naive patients with subfoveal occult choroidal neovascularization secondary to age-related macular degeneration: A 12-month follow-up study
    • Costagliola, C, Romano M, Corte MD, et al. Intravitreal bevacizu-mab for treatment-naive patients with subfoveal occult choroidal neovascularization secondary to age-related macular degeneration: a 12-month follow-up study. Retina 2009; 29: 1227-1234.
    • (2009) Retina , vol.29 , pp. 1227-1234
    • Costagliola, C.1    Romano, M.2    Corte, M.D.3
  • 90
    • 35348974645 scopus 로고    scopus 로고
    • Intravitreal bevacizu-mab vs. verteporfin photodynamic therapy for neovascular age-related macular degeneration
    • Bashshur ZF, Schakal, A, Hamam RN, et al. Intravitreal bevacizu-mab vs. verteporfin photodynamic therapy for neovascular age-related macular degeneration. Arch Ophthalmol 2007; 125: 1357-1361.
    • (2007) Arch Ophthalmol , vol.125 , pp. 1357-1361
    • Bashshur, Z.F.1    Schakal, A.2    Hamam, R.N.3
  • 91
    • 77954106891 scopus 로고    scopus 로고
    • ABC Trial Investigators. Bevacizumab for neovascular age related macular degeneration (ABC Trial): Multicentre randomised double masked study
    • Tufail A, Patel PJ, Egan C, et al. ABC Trial Investigators. Bevacizumab for neovascular age related macular degeneration (ABC Trial): multicentre randomised double masked study. BMJ 2010; 340: c2459.
    • (2010) BMJ , vol.340
    • Tufail, A.1    Patel, P.J.2    Egan, C.3
  • 92
    • 33749426139 scopus 로고    scopus 로고
    • The price of sight-ranibizumab, bevacizumab, and the treatment of macular degeneration
    • Steinbrook R. The price of sight-ranibizumab, bevacizumab, and the treatment of macular degeneration. N Eng J Med 2006; 355: 1409-1412.
    • (2006) N Eng J Med , vol.355 , pp. 1409-1412
    • Steinbrook, R.1
  • 93
    • 34250792237 scopus 로고    scopus 로고
    • Intravitreal bevacizu-mab (Avastin) for occult choroidal neovascularisation in age-related macular degeneration
    • Aisenbrey S, Ziemssen F, Volker M, et al. Intravitreal bevacizu-mab (Avastin) for occult choroidal neovascularisation in age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 2007; 245: 941-948.
    • (2007) Graefe's Arch Clin Exp Ophthalmol , vol.245 , pp. 941-948
    • Aisenbrey, S.1    Ziemssen, F.2    Volker, M.3
  • 94
    • 77955410481 scopus 로고    scopus 로고
    • Intravitreal bevacizumab has initial clinical benefit lasting eight weeks in eyes with neovacular age -related macular degeneration
    • Conrad PW, Zacks DN, Johnson MW Intravitreal bevacizumab has initial clinical benefit lasting eight weeks in eyes with neovacular age -related macular degeneration. Clin Ophthalmol 2008; 2: 727-733.
    • (2008) Clin Ophthalmol , vol.2 , pp. 727-733
    • Conrad, P.W.1    Zacks, D.N.2    Johnson, M.W.3
  • 96
    • 30044436689 scopus 로고    scopus 로고
    • A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165
    • Lee JH, Canny MD, De Erkenez A, et al. A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc Natl Acad Sci USA 2005; 102: 18902-18907.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18902-18907
    • Lee, J.H.1    Canny, M.D.2    de Erkenez, A.3
  • 97
    • 3242734630 scopus 로고    scopus 로고
    • Aptamers, intramers, and vascular endo-thelial growth factor
    • Waheed NK, Miller JW. Aptamers, intramers, and vascular endo-thelial growth factor. Int Ophthalmol Clin 2004; 44: 11-22.
    • (2004) Int Ophthalmol Clin , vol.44 , pp. 11-22
    • Waheed, N.K.1    Miller, J.W.2
  • 98
    • 0043125643 scopus 로고    scopus 로고
    • VEGF 164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularisation
    • Ishida S, Usui T, Yamashiro K, et al. VEGF 164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularisation. J Exp Med 2003; 198: 483-489.
    • (2003) J Exp Med , vol.198 , pp. 483-489
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 99
    • 0037407757 scopus 로고    scopus 로고
    • VEGF 164 is proinflamma-tory in the diabetic retina
    • Ishida S, Usui T, Yamashiro K, et al. VEGF 164 is proinflamma-tory in the diabetic retina. Invest Ophthalmol Vis Sci 2003; 44: 2155-2162.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2155-2162
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3
  • 101
    • 73649108258 scopus 로고    scopus 로고
    • Anti-VEGF agents for age-related macular degeneration
    • Özkiris A. Anti-VEGF agents for age-related macular degeneration. Expert Opin Ther Pat 2010; 20: 103-118.
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 103-118
    • Özkiris, A.1
  • 102
    • 11144239923 scopus 로고    scopus 로고
    • VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age related macular degeneration
    • Gragoudas ES, Adamis AP, Cunningham ET Jr, et al. VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age related macular degeneration. N Engl J Med 2004; 351: 2805-2816.
    • (2004) N Engl J Med , vol.351 , pp. 2805-2816
    • Gragoudas, E.S.1    Adamis, A.P.2    Cunningham Jr., E.T.3
  • 103
    • 34247562266 scopus 로고    scopus 로고
    • Chakravarthy U, Adamis AP, Cunningam ET Jr, Katz B, Patel M. Year 2 efficacy results of 2 randomised controlled clinical trials of pegaptanib for neovascular age related macular degeneration
    • VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group
    • VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Chakravarthy U, Adamis AP, Cunningam ET Jr, Katz B, Patel M. Year 2 efficacy results of 2 randomised controlled clinical trials of pegaptanib for neovascular age related macular degeneration. Ophthalmology 2006; 113: 1508-1525.
    • (2006) Ophthalmology , vol.113 , pp. 1508-1525
  • 104
    • 57149091202 scopus 로고    scopus 로고
    • Pegaptanib sodium for neovascular age-related macular degeneration: Third-year safety results of the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Trial
    • Singerman LJ, Masonson H, Patel M, et al. Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Trial. Br J Ophthalmol 2008; 92: 1606-1611.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1606-1611
    • Singerman, L.J.1    Masonson, H.2    Patel, M.3
  • 105
    • 33749445317 scopus 로고    scopus 로고
    • MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier, JS, et al. MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1419-1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 106
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab vs. verte-porfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumab vs. verte-porfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-1444.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 107
    • 33845399973 scopus 로고    scopus 로고
    • San Francisco,Calif. Genentech Inc
    • (2006) Lucentis [package insert]. San Francisco,Calif. Genentech Inc.
    • (2006) Lucentis [package Insert]
  • 108
    • 15044349368 scopus 로고    scopus 로고
    • Inhibitors of ocular neovascularization: Promises and potential problems
    • van Wijngaarden P, Coster DJ, Williams KA. Inhibitors of ocular neovascularization: promises and potential problems. JAMA 2005; 293: 1509-1513.
    • (2005) JAMA , vol.293 , pp. 1509-1513
    • van Wijngaarden, P.1    Coster, D.J.2    Williams, K.A.3
  • 109
    • 33947403618 scopus 로고    scopus 로고
    • An optical coherence tomography-guided, variable dosing regimen with intravitreal ra-nibizumab (Lucentis) for neovascular age-related macular degeneration
    • Fung AE, Lalwani GA, Rosenfeld PJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ra-nibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol 2007; 143: 566-583.
    • (2007) Am J Ophthalmol , vol.143 , pp. 566-583
    • Fung, A.E.1    Lalwani, G.A.2    Rosenfeld, P.J.3
  • 110
    • 67149101784 scopus 로고    scopus 로고
    • A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: Year 2 of the PrONTO Study
    • Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Oph-thalmol 2009; 148: 43-58.
    • (2009) Am J Oph-thalmol , vol.148 , pp. 43-58
    • Lalwani, G.A.1    Rosenfeld, P.J.2    Fung, A.E.3
  • 111
    • 77951573226 scopus 로고    scopus 로고
    • Lucentis at one year. Available at http://www.eyeworld.org/prin-tarticle.php?id=4390.
    • Lucentis At One Year
  • 112
    • 38349172455 scopus 로고    scopus 로고
    • Randomized, double-masked, shamcontrolled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    • Regillo CD, Brown DM, Abraham P, et al. Randomized, double-masked, shamcontrolled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1. Am J Ophthal-mol 2008; 145: 239-248.
    • (2008) Am J Ophthal-mol , vol.145 , pp. 239-248
    • Regillo, C.D.1    Brown, D.M.2    Abraham, P.3
  • 113
    • 84962457767 scopus 로고    scopus 로고
    • On behalf of the EXCITE study group. Visual Acuity Response Profiles in Patients With Neovascular Age-related Macular Degeneration Treated Quarterly With Ranibizumab in the EXCITE Trial
    • E-Abstract 2374
    • Eldem MB, Bartz-Schmidt KU, Schlingemann RO, Guymer R, Axer-Siegel R. On behalf of the EXCITE study group. Visual Acuity Response Profiles in Patients With Neovascular Age-related Macular Degeneration Treated Quarterly With Ranibizumab in the EXCITE Trial. Invest Ophthalmol Vis Sci 2009; 50: E-Abstract 2374.
    • (2009) Invest Ophthalmol Vis Sci , pp. 50
    • Eldem, M.B.1    Bartz-Schmidt, K.U.2    Schlingemann, R.O.3    Guymer, R.4    Axer-Siegel, R.5
  • 114
    • 80051730383 scopus 로고    scopus 로고
    • On behalf of the SUSTAIN study group. Visual Acuity and Central Retinal Thickness Response Profiles and Treatment Patterns in Patients With Neovascular AMD Treated With Ranibizumab in the SUSTAIN Study
    • E-Abstract 2366
    • Kirchhoff B, Kellner U, Holz FG, Schlingemann RO On behalf of the SUSTAIN study group. Visual Acuity and Central Retinal Thickness Response Profiles and Treatment Patterns in Patients With Neovascular AMD Treated With Ranibizumab in the SUSTAIN Study. Invest Ophthalmol Vis Sci 2009 50: E-Abstract 2366.
    • (2009) Invest Ophthalmol Vis Sci , pp. 50
    • Kirchhoff, B.1    Kellner, U.2    Holz, F.G.3    Schlingemann, R.O.4
  • 115
    • 33750314559 scopus 로고    scopus 로고
    • FOCUS Study Group. Ra-nibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS Study
    • Erratum in: Arch Ophthalmol 2007; 125: 138
    • Heier JS, Boyer DS, Ciulla TA, et al. FOCUS Study Group. Ra-nibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS Study. Arch Ophthalmol 2006; 124: 1532-1542. Erratum in: Arch Ophthalmol 2007; 125: 138.
    • (2006) Arch Ophthalmol , vol.124 , pp. 1532-1542
    • Heier, J.S.1    Boyer, D.S.2    Ciulla, T.A.3
  • 116
    • 43049176776 scopus 로고    scopus 로고
    • FOCUS Study Group. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): Year 2 results
    • Antoszyk AN, Tuomi L, Chung CY, Singh A. FOCUS Study Group. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results. Am J Ophthalmol 2008; 145: 862-874.
    • (2008) Am J Ophthalmol , vol.145 , pp. 862-874
    • Antoszyk, A.N.1    Tuomi, L.2    Chung, C.Y.3    Singh, A.4
  • 117
    • 57149115612 scopus 로고    scopus 로고
    • Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularisation due to age-related macular degeneration
    • PROTECT Study Group
    • Schmidt-Erfurth U, Wolf S. PROTECT Study Group. Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularisation due to age-related macular degeneration. Br J Ophthalmol 2008; 92: 1628-1635.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1628-1635
    • Schmidt-Erfurth, U.1    Wolf, S.2
  • 118
    • 74349121042 scopus 로고    scopus 로고
    • ®) for Neovascular Age-Related Macular Degeneration (AMD): Two-Year Safety and Efficacy Results
    • E-Abstract 3093
    • ®) for Neovascular Age-Related Macular Degeneration (AMD): Two-Year Safety and Efficacy Results. Invest Ophthalmol Vis Sci 2009; 50: E-Abstract 3093.
    • (2009) Invest Ophthalmol Vis Sci , pp. 50
    • Singer, M.1    Wong, P.2    Wang, P.W.3    Scott, L.4
  • 120
    • 43749096100 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Potential therapies
    • Chappelow AV, Kaiser PK. Neovascular age-related macular degeneration: potential therapies. Drugs 2008; 68: 1029-1036.
    • (2008) Drugs , vol.68 , pp. 1029-1036
    • Chappelow, A.V.1    Kaiser, P.K.2
  • 122
    • 65249175197 scopus 로고    scopus 로고
    • Suppression and regression of choroidal neovasculariza-tion by the multitargeted kinase inhibitor pazopanib
    • Takahashi K, Saishin Y, Saishin Y, King AG, Levin R, Campo-chiaro PA. Suppression and regression of choroidal neovasculariza-tion by the multitargeted kinase inhibitor pazopanib. Arch Oph-thalmol 2009; 127: 494-499.
    • (2009) Arch Oph-thalmol , vol.127 , pp. 494-499
    • Takahashi, K.1    Saishin, Y.2    Saishin, Y.3    King, A.G.4    Levin, R.5    Campo-Chiaro, P.A.6
  • 124
    • 41149178633 scopus 로고    scopus 로고
    • Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovasculari-zation and retinal edema
    • Doukas J, Mahesh S, Umeda N, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovasculari-zation and retinal edema. J Cell Physiol 2008; 216: 29-37.
    • (2008) J Cell Physiol , vol.216 , pp. 29-37
    • Doukas, J.1    Mahesh, S.2    Umeda, N.3
  • 126
    • 67649629310 scopus 로고    scopus 로고
    • A Dual VEGFR/JAK2 Kinase Inhibitor Suitable for Topical Delivery Inhibits Choroid Neovascu-larization in Mice
    • E-Abstract 1469
    • Chen ZZ, Mak C, Renick J, et al. A Dual VEGFR/JAK2 Kinase Inhibitor Suitable for Topical Delivery Inhibits Choroid Neovascu-larization in Mice. Invest Ophthalmol Vis Sci 2007; 48: E-Abstract 1469.
    • (2007) Invest Ophthalmol Vis Sci , pp. 48
    • Chen, Z.Z.1    Mak, C.2    Renick, J.3
  • 127
    • 22144442836 scopus 로고    scopus 로고
    • Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice
    • Maier P, Unsoeld AS, Junker B, et al. Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice. Graefes Arch Clin Exp Ophthalmol 2005; 243: 593-600.
    • (2005) Graefes Arch Clin Exp Ophthalmol , vol.243 , pp. 593-600
    • Maier, P.1    Unsoeld, A.S.2    Junker, B.3
  • 129
    • 80051737767 scopus 로고    scopus 로고
    • AL-39324 is more potent and efficacious against ocular NV vs. other RTKi's
    • abstract no. E-1747
    • Bingaman DP, Gu X, Landers RA, et al. AL-39324 is more potent and efficacious against ocular NV vs. other RTKi's. Invest Oph-thalmol Vis Sci 2007; 48 (5) [abstract no. E-1747].
    • (2007) Invest Oph-thalmol Vis Sci , vol.48 , Issue.5
    • Bingaman, D.P.1    Gu, X.2    Landers, R.A.3
  • 130
    • 68049147292 scopus 로고    scopus 로고
    • Drug delivery strategies for combination ophthalmic treatments
    • Kuppermann BD. Drug delivery strategies for combination ophthalmic treatments. Retina 2009; 29: 24-26.
    • (2009) Retina , vol.29 , pp. 24-26
    • Kuppermann, B.D.1
  • 131
    • 67149101784 scopus 로고    scopus 로고
    • A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: Year 2 of the PrONTO Study
    • Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Oph-thalmol 2009; 148: 43 el-58 el.
    • (2009) Am J Oph-thalmol , vol.148 , Issue.43
    • Lalwani, G.A.1    Rosenfeld, P.J.2    Fung, A.E.3
  • 132
    • 75749133304 scopus 로고    scopus 로고
    • The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: Outcomes of a drug and disease model
    • Holz FG, Korobelnik JF, Lanzetta P, et al. The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: outcomes of a drug and disease model. Invest Ophthalmol Vis Sci 2010; 51: 405-412.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 405-412
    • Holz, F.G.1    Korobelnik, J.F.2    Lanzetta, P.3
  • 133
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 134
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOL-FOX4) for previousltreated metastatic colorectal cancer: Results fromEastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOL-FOX4) for previousltreated metastatic colorectal cancer: results fromEastern Cooperative Oncology Group Study E3200. Oncol 2007; 25: 1539-1544.
    • (2007) Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 135
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 136
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus combination interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus combination interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 137
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab vs. paclitaxel alone for metastatic breast cancer
    • Miller KD, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab vs. paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.D.1    Wang, M.2    Gralow, J.3
  • 138
    • 84855661085 scopus 로고    scopus 로고
    • US Food and Drug Administration, Barron, H. Genen-tech. Important drug warning (letter)
    • US Food and Drug Administration. MedWatch. Barron, H. Genen-tech. Important drug warning (letter). http://www.fda.gow/ med-watch/Safety/2005/Avastindearhcp.pdf. 2005
    • (2005) MedWatch
  • 139
    • 0033506713 scopus 로고    scopus 로고
    • Cellular mechanism of blood-retinal barrier dysfunction in macular edema
    • Vinores SA, Derevkanik NL, Ozaki H, et al. Cellular mechanism of blood-retinal barrier dysfunction in macular edema. Doc Ophthal-mol 1999; 97: 217-228.
    • (1999) Doc Ophthal-mol , vol.97 , pp. 217-228
    • Vinores, S.A.1    Derevkanik, N.L.2    Ozaki, H.3
  • 140
    • 33746699073 scopus 로고    scopus 로고
    • Age-related macular degeneration and risk of stroke
    • Couper D, Lai H, Hubbard LD, et al. Age-related macular degeneration and risk of stroke. Ann Intern Med 2006; 145: 98-107.
    • (2006) Ann Intern Med , vol.145 , pp. 98-107
    • Couper, D.1    Lai, H.2    Hubbard, L.D.3
  • 141
    • 33947601440 scopus 로고    scopus 로고
    • Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans
    • Duan Y, Mo J, Klein R, et al. Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans. Ophthalmology 2007; 114: 732-737.
    • (2007) Ophthalmology , vol.114 , pp. 732-737
    • Duan, Y.1    Mo, J.2    Klein, R.3
  • 142
    • 80051755459 scopus 로고    scopus 로고
    • Clinical update: New treatments for age related macular degeneration in the UK
    • Wong TY, Liew G, Mitchell P. Clinical update: new treatments for age related macular degeneration in the UK. Pharmacoeconomics 2007; 25: 863-879.
    • (2007) Pharmacoeconomics , vol.25 , pp. 863-879
    • Wong, T.Y.1    Liew, G.2    Mitchell, P.3
  • 143
    • 65349115442 scopus 로고    scopus 로고
    • Cardiovascular risk and antiangiogenic therapy for age-related macular degeneration
    • Tuñón J, Ruiz-Moreno JM, Martín-Ventura JL, et al. Cardiovascular risk and antiangiogenic therapy for age-related macular degeneration. Surv Ophthalmol 2009; 54: 339-348.
    • (2009) Surv Ophthalmol , vol.54 , pp. 339-348
    • Tuñón, J.1    Ruiz-Moreno, J.M.2    Martín-Ventura, J.L.3
  • 144
    • 0034466813 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys
    • Drolet DW, Nelson J, Tucker CE, et al. Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys. Pharm Res 2000; 17: 1503-1510.
    • (2000) Pharm Res , vol.17 , pp. 1503-1510
    • Drolet, D.W.1    Nelson, J.2    Tucker, C.E.3
  • 145
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administration
    • Gaudreault J, Fei D, Rusit, J, et al. Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci 2005; 46: 726-733.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3
  • 146
    • 77956586572 scopus 로고    scopus 로고
    • Plasma levels of vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab
    • Matsuyama K, Ogata N, Matsuoka M, et al. Plasma levels of vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab. Br J Ophthalmol 2010; 94: 1215-1218.
    • (2010) Br J Ophthalmol , vol.94 , pp. 1215-1218
    • Matsuyama, K.1    Ogata, N.2    Matsuoka, M.3
  • 147
    • 0020038842 scopus 로고
    • Pharmacokinetics of topically applied ophthalmic drugs
    • Shell JW. Pharmacokinetics of topically applied ophthalmic drugs. Surv Ophthalmol 1982; 26: 207-218.
    • (1982) Surv Ophthalmol , vol.26 , pp. 207-218
    • Shell, J.W.1
  • 148
    • 84855697645 scopus 로고    scopus 로고
    • www.pfizer.com/products/rx_product_macugen.jsp.
  • 149
    • 80051773436 scopus 로고    scopus 로고
    • Intraocular pharmacokinet-ics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation
    • Mordenti J, Thomsen K, Licko V, et al. Intraocular pharmacokinet-ics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation. Toxicol Sci 1999; 29: 579-585
    • (1999) Toxicol Sci , vol.29 , pp. 579-585
    • Mordenti, J.1    Thomsen, K.2    Licko, V.3
  • 150
    • 33646464758 scopus 로고    scopus 로고
    • Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab
    • Shahar J, Avery L, Heilweil G, et al. Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab. Retina 2006; 26: 262-269.
    • (2006) Retina , vol.26 , pp. 262-269
    • Shahar, J.1    Avery, L.2    Heilweil, G.3
  • 151
    • 34347213068 scopus 로고    scopus 로고
    • Penetration bof bevaci-zumab through the retina after intravitrea administration in the monkey
    • Heiduschka P, Fietz H, Hofmeister S, et al. Penetration bof bevaci-zumab through the retina after intravitrea administration in the monkey. Invest Ophthalmol Vis Sci 2007; 48: 2814-2823.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2814-2823
    • Heiduschka, P.1    Fietz, H.2    Hofmeister, S.3
  • 153
    • 33748982649 scopus 로고    scopus 로고
    • Intravitreal bevacizu-mab (Avastin) in the treatment of proliferative diabetic retinopathy
    • Avery RL, Pearlman J, Pieramici DJ, et al. Intravitreal bevacizu-mab (Avastin) in the treatment of proliferative diabetic retinopathy. Ophthalmology 2006; 113: 1695-1705.
    • (2006) Ophthalmology , vol.113 , pp. 1695-1705
    • Avery, R.L.1    Pearlman, J.2    Pieramici, D.J.3
  • 154
    • 34547804337 scopus 로고    scopus 로고
    • Acute retinal pigment epithelial tear in the untreated fellow eye following repeated bevacizumab (Avastin) injections
    • Mennel S, Callizo J, Schmidt JC, Meyer CH. Acute retinal pigment epithelial tear in the untreated fellow eye following repeated bevacizumab (Avastin) injections. Acta Ophthalmol Scand 2007; 85: 689-691.
    • (2007) Acta Ophthalmol Scand , vol.85 , pp. 689-691
    • Mennel, S.1    Callizo, J.2    Schmidt, J.C.3    Meyer, C.H.4
  • 155
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001; 19: 843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 156
  • 157
    • 80051712663 scopus 로고    scopus 로고
    • Intravitreal VEGF-inhibitors: Is Avastin a generic substitute for Lucentis?
    • La Cour M. Intravitreal VEGF-inhibitors: is Avastin a generic substitute for Lucentis? Acta Ophthalmol Scand 2007; 114: 855-859.
    • (2007) Acta Ophthalmol Scand , vol.114 , pp. 855-859
    • la Cour, M.1
  • 158
    • 34548262708 scopus 로고    scopus 로고
    • Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age related macular degeneration
    • Macugen AMD Study Group 2007
    • Macugen AMD Study Group 2007. Apte RS, Modi M, Masonson H, et al. Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age related macular degeneration. Ophthalmology 2007; 114: 1702-1712.
    • (2007) Ophthalmology , vol.114 , pp. 1702-1712
    • Apte, R.S.1    Modi, M.2    Masonson, H.3
  • 159
    • 36549039554 scopus 로고    scopus 로고
    • Pharmacokinetics of in-travitreal ranibizumab (lucentis)
    • Bakri SJ, Snyder MR, Reid JM, et al. Pharmacokinetics of in-travitreal ranibizumab (lucentis). Ophthalmology 2007; 114: 2179-2182.
    • (2007) Ophthalmology , vol.114 , pp. 2179-2182
    • Bakri, S.J.1    Snyder, M.R.2    Reid, J.M.3
  • 160
    • 80051755459 scopus 로고    scopus 로고
    • Clinical update: New treatments for age related macular degeneration in the UK
    • Wong TY, Liew G, Mitchell P. Clinical update: new treatments for age related macular degeneration in the UK. Pharmacoeconomics 2007; 25: 863-879.
    • (2007) Pharmacoeconomics , vol.25 , pp. 863-879
    • Wong, T.Y.1    Liew, G.2    Mitchell, P.3
  • 161
    • 33749632278 scopus 로고    scopus 로고
    • Developmant of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara N, Damico L, Shams N, Lowman H, Kim R. Developmant of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006; 26: 859-870.
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3    Lowman, H.4    Kim, R.5
  • 162
    • 35448940430 scopus 로고    scopus 로고
    • New treatments for age-related macular degeneration
    • author reply 1480
    • Avery RL. New treatments for age-related macular degeneration. Lancet 2007; 370(9597): 1479-1480; author reply 1480.
    • (2007) Lancet , vol.370 , Issue.9597 , pp. 1479-1480
    • Avery, R.L.1
  • 163
    • 68249149799 scopus 로고    scopus 로고
    • Tuebingen Bevacizumab Study Group, Ziemssen T. Intensified monitoring of circadian blood pressure and heart rate before and after intravitreous injection of bevacizumab: Preliminary findings of a pilot study
    • Epub 2008 Apr 17
    • Ziemssen F, Zhu Q, Peters S, et al. Tuebingen Bevacizumab Study Group, Ziemssen T. Intensified monitoring of circadian blood pressure and heart rate before and after intravitreous injection of bevacizumab: preliminary findings of a pilot study. Int Ophthalmol 2009; 29: 213-224. Epub 2008 Apr 17.
    • (2009) Int Ophthalmol , vol.29 , pp. 213-224
    • Ziemssen, F.1    Zhu, Q.2    Peters, S.3
  • 164
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second line treatment of colorectal cancer
    • Cohen, MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab plus FOLFOX4 as second line treatment of colorectal cancer. Oncologist 2007; 12: 356-361.
    • (2007) Oncologist , vol.12 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 165
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 166
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevaci-zumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevaci-zumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005; 23: 3697-705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 167
    • 69249100970 scopus 로고    scopus 로고
    • Current perspective: Bevacizumab in colorectal cancer--a time for reappraisal?
    • Okines A, Cunningham D. Current perspective: bevacizumab in colorectal cancer--a time for reappraisal? Eur J Cancer 2009; 45: 2452-2461.
    • (2009) Eur J Cancer , vol.45 , pp. 2452-2461
    • Okines, A.1    Cunningham, D.2
  • 168
    • 34548141828 scopus 로고    scopus 로고
    • Arterial throm-boembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • 1232-9, Epub 2007 Aug 8. Erratum in: J Natl Cancer Inst 2008; 100: 156. J Natl Cancer Inst 2008; 100: 685
    • Scappaticci FA, Skillings JR, Holden SN, et al. Arterial throm-boembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007; 99: 1232-9. Epub 2007 Aug 8. Erratum in: J Natl Cancer Inst 2008; 100: 156. J Natl Cancer Inst 2008; 100: 685.
    • (2007) J Natl Cancer Inst , vol.99
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 169
    • 0034979275 scopus 로고    scopus 로고
    • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
    • Zachary, I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol 2001; 280: C1375-C1386.
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. 1375-1386
    • Zachary, I.1
  • 170
    • 74749102214 scopus 로고    scopus 로고
    • Effects of in-travitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration
    • Mete A, Saygili O, Mete A, Bayram M, Bekir N. Effects of in-travitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration. J Clin Ultrasound 2010; 38: 66-70.
    • (2010) J Clin Ultrasound , vol.38 , pp. 66-70
    • Mete, A.1    Saygili, O.2    Mete, A.3    Bayram, M.4    Bekir, N.5
  • 171
    • 77649227816 scopus 로고    scopus 로고
    • Retinal artery occlusion following intravitreal anti-VEGF therapy
    • Epub 2009 Apr 8
    • von Hanno T, Kinge B, Fossen K. Retinal artery occlusion following intravitreal anti-VEGF therapy. Acta Ophthalmol 2010; 88: 263-266. Epub 2009 Apr 8.
    • (2010) Acta Ophthalmol , vol.88 , pp. 263-266
    • von Hanno, T.1    Kinge, B.2    Fossen, K.3
  • 172
    • 0033520056 scopus 로고    scopus 로고
    • Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
    • Rosengart TK, Lee LY, Patel SR, et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 1999; 100: 468-474.
    • (1999) Circulation , vol.100 , pp. 468-474
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3
  • 174
    • 65549162660 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
    • Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009; 20: 158-165.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 158-165
    • Ciulla, T.A.1    Rosenfeld, P.J.2
  • 175
    • 74549137478 scopus 로고    scopus 로고
    • Ranibizumab (Lucen-tis) in neovascular age-related macular degeneration: Evidence from clinical trials
    • Epub 2009 May 13
    • Mitchell P, Korobelnik JF, Lanzetta P, et al. Ranibizumab (Lucen-tis) in neovascular age-related macular degeneration: evidence from clinical trials. Br J Ophthalmol 2010; 94: 2-13. Epub 2009 May 13.
    • (2010) Br J Ophthalmol , vol.94 , pp. 2-13
    • Mitchell, P.1    Korobelnik, J.F.2    Lanzetta, P.3
  • 176
    • 84984768624 scopus 로고    scopus 로고
    • Should avastin be used to treat age-related macular degeneration in the NHS?--No
    • Chong NV. Should avastin be used to treat age-related macular degeneration in the NHS?--No. Eye (Lond) 2009; 23: 1250-1253.
    • (2009) Eye (Lond) , vol.23 , pp. 1250-1253
    • Chong, N.V.1
  • 178
    • 33750296920 scopus 로고    scopus 로고
    • The International Intravitreal Bevacizumab Safety Survey: Using the internet to assess drug safety worldwide
    • Epub 2006 Jul 19
    • Fung AE, Rosenfeld PJ, Reichel E. The International Intravitreal Bevacizumab Safety Survey: using the internet to assess drug safety worldwide. Br J Ophthalmol 2006; 90: 1344-1349. Epub 2006 Jul 19.
    • (2006) Br J Ophthalmol , vol.90 , pp. 1344-1349
    • Fung, A.E.1    Rosenfeld, P.J.2    Reichel, E.3
  • 181
    • 84855684579 scopus 로고    scopus 로고
    • CATT study, Lucentis-Avastin Trial, National Eye Institute
    • CATT study: Comparison of AMD Treatment Trials: Lucentis-Avastin Trial, National Eye Institute, 2008 www.clinicaltrials.gov.
    • (2008) Comparison of AMD Treatment Trials
  • 182
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. (2007) Br J Cancer 2007; 96: 1788-1795.
    • (2007) Br J Cancer , vol.2007 , Issue.96 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 183
    • 0031943236 scopus 로고    scopus 로고
    • VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
    • Hood JD, Meininger CJ, Ziche M, et al. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 1998; 274: H1054-H1058.
    • (1998) Am J Physiol , vol.274 , pp. 1054-1058
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3
  • 184
    • 33845656482 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors for bevacizumab-induced hypertension
    • Dincer M, Altundag K. Angiotensin-converting enzyme inhibitors for bevacizumab-induced hypertension. Ann Pharmacother 2006; 40: 2278.
    • (2278) Ann Pharmacother , vol.2006 , pp. 40
    • Dincer, M.1    Altundag, K.2
  • 185
    • 12444304260 scopus 로고    scopus 로고
    • Angiogenic growth factors and hypertension
    • Sane DC, Anton L, Brosnihan KP. Angiogenic growth factors and hypertension. Angiogenesis 2004; 7: 193-201.
    • (2004) Angiogenesis , vol.7 , pp. 193-201
    • Sane, D.C.1    Anton, L.2    Brosnihan, K.P.3
  • 186
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treated with bevacizumab combination therapy
    • Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy. Oncology 2005; 69: S25-S33.
    • (2005) Oncology , vol.69 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 187
    • 43049085201 scopus 로고    scopus 로고
    • Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation
    • Mourad JJ, des Guetz G, Debbabi H, Levy BI. Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation. Ann Oncol 2008; 19: 927-934.
    • (2008) Ann Oncol , vol.19 , pp. 927-934
    • Mourad, J.J.1    des Guetz, G.2    Debbabi, H.3    Levy, B.I.4
  • 188
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358: 1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 189
    • 27244452463 scopus 로고    scopus 로고
    • Hypertension associated with bevacizumab
    • Rosiak J, Sadowski L. Hypertension associated with bevacizumab. Clin J Oncol Nurs 2005; 9: 407-411.
    • (2005) Clin J Oncol Nurs , vol.9 , pp. 407-411
    • Rosiak, J.1    Sadowski, L.2
  • 190
    • 79952038413 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration: A safety review
    • 2010 Oct 22, Epub ahead of print
    • Schmucker C, Loke YK, Ehlken C, et al. Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration: a safety review. Br J Ophthalmol 2010 Oct 22. [Epub ahead of print]
    • Br J Ophthalmol
    • Schmucker, C.1    Loke, Y.K.2    Ehlken, C.3
  • 191
    • 47649125703 scopus 로고    scopus 로고
    • Complications in patients after intravitreal injection of bevacizumab
    • Shima C, Sakaguchi H, Gomi F, et al. Complications in patients after intravitreal injection of bevacizumab. Acta Ophthalmol. 2008; 86: 372-376.
    • (2008) Acta Ophthalmol , vol.86 , pp. 372-376
    • Shima, C.1    Sakaguchi, H.2    Gomi, F.3
  • 192
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-716.
    • (2003) J Clin Invest , vol.111 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 193
    • 2442707596 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor (VEGF) in renal pathophysiology
    • Schrijvers BF, Flyvbjerg A, De Vriese AS. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 2004; 65: 2003-2017.
    • (2004) Kidney Int , vol.65 , pp. 2003-2017
    • Schrijvers, B.F.1    Flyvbjerg, A.2    de Vriese, A.S.3
  • 194
    • 0037631361 scopus 로고    scopus 로고
    • Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinu-ria
    • Sugimoto H, Hamano Y, Charytan D, et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinu-ria. J Biol Chem 2003; 278: 12605-12608.
    • (2003) J Biol Chem , vol.278 , pp. 12605-12608
    • Sugimoto, H.1    Hamano, Y.2    Charytan, D.3
  • 195
    • 36849054884 scopus 로고    scopus 로고
    • Safety of consolidation bevacizumab after first line chemotherapy for advanced ovarian cancer
    • Campos S, Dizon DS, Cannistra SA, et al. Safety of consolidation bevacizumab after first line chemotherapy for advanced ovarian cancer. J Clin Oncol 2007; 25: 278s.
    • (2007) J Clin Oncol , vol.25
    • Campos, S.1    Dizon, D.S.2    Cannistra, S.A.3
  • 196
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005; 23: 792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 197
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22: 2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny3
  • 198
    • 52949130889 scopus 로고    scopus 로고
    • What is the risk of intracra-nial bleeding during anti-VEGF therapy?
    • Carden CP, Larkin JM, Rosenthal MA. What is the risk of intracra-nial bleeding during anti-VEGF therapy? Neuro Oncol 2008; 10: 624-630.
    • (2008) Neuro Oncol , vol.10 , pp. 624-630
    • Carden, C.P.1    Larkin, J.M.2    Rosenthal, M.A.3
  • 199
    • 33845961014 scopus 로고    scopus 로고
    • Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
    • Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther 2006; 28: 1779-1802.
    • (2006) Clin Ther , vol.28 , pp. 1779-1802
    • Shih, T.1    Lindley, C.2
  • 200
    • 0142121282 scopus 로고    scopus 로고
    • Bevacizumab, bleeding, thrombosis, and warfarin
    • Kilickap S, Abali H, Celik I. Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003; 21: 3542.
    • (2003) J Clin Oncol , vol.21 , pp. 3542
    • Kilickap, S.1    Abali, H.2    Celik, I.3
  • 201
    • 33745926802 scopus 로고    scopus 로고
    • VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
    • Tam BY, Wei K, Rudge JS, et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med 2006; 12: 793-800.
    • (2006) Nat Med , vol.12 , pp. 793-800
    • Tam, B.Y.1    Wei, K.2    Rudge, J.S.3
  • 202
    • 69249222585 scopus 로고    scopus 로고
    • A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration
    • Boyer DS, Heier JS, Brown DM, Francom SF, Ianchulev T, Rubio RG. A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration. Ophthalmology 2009; 116: 1731-1739.
    • (2009) Ophthalmology , vol.116 , pp. 1731-1739
    • Boyer, D.S.1    Heier, J.S.2    Brown, D.M.3    Francom, S.F.4    Ianchulev, T.5    Rubio, R.G.6
  • 203
    • 33749587286 scopus 로고    scopus 로고
    • Reversible posterior leukoen-cephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer
    • Allen JA, Adlakha A, Bergethon PR. Reversible posterior leukoen-cephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer. Arch Neurol 2006; 63: 1475-1478.
    • (2006) Arch Neurol , vol.63 , pp. 1475-1478
    • Allen, J.A.1    Adlakha, A.2    Bergethon, P.R.3
  • 204
    • 34047219240 scopus 로고    scopus 로고
    • Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer
    • Grothey A. Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer. Oncology 2006; 20(14 Suppl 10): 1-8.
    • (2006) Oncology , vol.20 , Issue.14 SUPPL 10 , pp. 1-8
    • Grothey, A.1
  • 205
    • 29944431768 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in wound healing
    • Bates DO, Jones RO. The role of vascular endothelial growth factor in wound healing. Int J Low Extrem Wounds 2003; 2: 107-120.
    • (2003) Int J Low Extrem Wounds , vol.2 , pp. 107-120
    • Bates, D.O.1    Jones, R.O.2
  • 206
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol 2005; 91: 173-180.
    • (2005) J Surg Oncol , vol.91 , pp. 173-180
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3
  • 207
    • 29144510498 scopus 로고    scopus 로고
    • The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice
    • Ko J, Ross J, Awad H, Hurwitz H, Klitzman B. The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice. J Surg Res 2005; 129: 251-259.
    • (2005) J Surg Res , vol.129 , pp. 251-259
    • Ko, J.1    Ross, J.2    Awad, H.3    Hurwitz, H.4    Klitzman, B.5
  • 208
    • 84858139464 scopus 로고    scopus 로고
    • Cost-utility analysis of bevacizumab vs. ranibizumab in neovascular age-related macular degeneration using a Markov model
    • 2010 Sep 16, Epub ahead of print
    • Patel JJ, Mendes MA, Bounthavong M, Christopher ML, Boggie D, Morreale AP. Cost-utility analysis of bevacizumab vs. ranibizumab in neovascular age-related macular degeneration using a Markov model. J Eval Clin Pract 2010 Sep 16. [Epub ahead of print]
    • J Eval Clin Pract
    • Patel, J.J.1    Mendes, M.A.2    Bounthavong, M.3    Christopher, M.L.4    Boggie, D.5    Morreale, A.P.6
  • 209
    • 77955302618 scopus 로고    scopus 로고
    • Cost-effectiveness of ra-nibizumab for the treatment of neovascular age-related macular degeneration in Germany: Model analysis from the perspective of Germany's statutory health insurance system
    • Neubauer AS, Holz FG, Sauer S, et al. Cost-effectiveness of ra-nibizumab for the treatment of neovascular age-related macular degeneration in Germany: Model analysis from the perspective of Germany's statutory health insurance system. Clin Ther 2010; 32: 1343-1356.
    • (2010) Clin Ther , vol.32 , pp. 1343-1356
    • Neubauer, A.S.1    Holz, F.G.2    Sauer, S.3
  • 210
    • 77951272899 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration: A systematic review
    • Schmucker C, Ehlken C, Hansen LL, Antes G, Agostini HT, Lel-gemann M. Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration: a systematic review. Curr Opin Ophthalmol 2010; 21: 218-226.
    • (2010) Curr Opin Ophthalmol , vol.21 , pp. 218-226
    • Schmucker, C.1    Ehlken, C.2    Hansen, L.L.3    Antes, G.4    Agostini, H.T.5    Lel-Gemann, M.6
  • 211
    • 44349110000 scopus 로고    scopus 로고
    • A value-based medicine analysis of ranibizumab for the treatment of subfoveal neovas-cular macular degeneration
    • Brown MM, Brown GC, Brown HC, Peet J. A value-based medicine analysis of ranibizumab for the treatment of subfoveal neovas-cular macular degeneration. Ophthalmology 2008; 115: 1039-1045.
    • (2008) Ophthalmology , vol.115 , pp. 1039-1045
    • Brown, M.M.1    Brown, G.C.2    Brown, H.C.3    Peet, J.4
  • 212
    • 61349102385 scopus 로고    scopus 로고
    • Economic implications of current age-related macular degeneration treatments
    • Smiddy WE. Economic implications of current age-related macular degeneration treatments. Ophthalmology 2009; 116: 481-487.
    • (2009) Ophthalmology , vol.116 , pp. 481-487
    • Smiddy, W.E.1
  • 213
    • 79955667358 scopus 로고    scopus 로고
    • Clinical evidence of intravitreal triamcinolone acetonide in the management of age-related macular degeneration
    • Becerra EM, Morescalchi F, Gandolfo F, et al. Clinical evidence of intravitreal triamcinolone acetonide in the management of age-related macular degeneration. Curr Drug Targets 2011; 12: 149-172.
    • (2011) Curr Drug Targets , vol.12 , pp. 149-172
    • Becerra, E.M.1    Morescalchi, F.2    Gandolfo, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.