Optimal oxidative folding of the novel antimicrobial cyclotide from hedyotis biflora requires high alcohol concentrations

Biochemistry

Volumn 50, Issue 33, 2011, Pages 7275-7283

  Wong, Clarence T T ^a   Taichi, Misako ^b   Nishio, Hideki ^b   Nishiuchi, Yuji ^b   Tam, James P ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b Peptide Institute Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2-PROPANOL; ACID HYDROLYSIS; ALCOHOL CONCENTRATIONS; COSOLVENTS; CYCLIC PEPTIDES; INVERSE ORIENTATION; LINEAR PRECURSORS; MEDICINAL PLANTS; MICROMOLAR RANGE; MINIMAL INHIBITORY CONCENTRATION; NATIVE FORMS; NET CHARGES; OXIDATIVE CONDITIONS; OXIDATIVE FOLDING; PARTIAL DENATURATION; PEPTIDE BACKBONES; PLANT DEFENSE; REDOX SYSTEMS; SIDE-CHAINS; SOLID PHASE SYNTHESIS; SYSTEMATIC STUDY; THIOESTERS;

AMINO ACIDS; CYCLIZATION; MICROORGANISMS; PEPTIDES; REDOX REACTIONS;

OPTIMIZATION;

2 PROPANOL; ALCOHOL; ANTIINFECTIVE AGENT; CYCLOTIDE; DISULFIDE; HEDYOTIDE B1; THIOESTER; THIOL; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DENATURATION; HEDYOTIS; HEDYOTIS BIFLORA; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SOLID PHASE SYNTHESIS;

ALCOHOLS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, LIQUID; CYCLIZATION; CYCLOTIDES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEDYOTIS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN FOLDING; TANDEM MASS SPECTROMETRY;

HEDYOTIS; POSIBACTERIA; THIA;

EID: 80051775850     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2007004     Document Type: Article

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