In vivo safety and persistence of endoribonuclease gene-transduced CD4+ t cells in cynomolgus macaques for HIV-1 gene therapy model

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Chono, Hideto ^a   Saito, Naoki ^a   Tsuda, Hiroshi ^a   Shibata, Hiroaki ^b   Ageyama, Naohide ^b   Terao, Keiji ^b   Yasutomi, Yasuhiro ^b   Mineno, Junichi ^a   Kato, Ikunoshin ^a  

^a TAKARA BIO INC   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDORIBONUCLEASE MAZF; RETROVIRUS VECTOR; RIBONUCLEASE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ENDONUCLEASE; ESCHERICHIA COLI PROTEIN; MAZF PROTEIN, E COLI;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOGENICITY; IN VIVO STUDY; LYMPHOID TISSUE; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; VIRAL GENE THERAPY; VIRUS REPLICATION; ANIMAL; AUTOTRANSPLANTATION; DISEASE MODEL; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPH NODE; MACACA FASCICULARIS; METABOLISM; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TIME; TRANSPLANTATION; TREATMENT OUTCOME;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; PRIMATES; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDONUCLEASES; ENDORIBONUCLEASES; ESCHERICHIA COLI PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION; GENE THERAPY; HIV INFECTIONS; HIV-1; HUMANS; LYMPH NODES; MACACA FASCICULARIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; TIME FACTORS; TRANSFECTION; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; VIRUS REPLICATION;

EID: 80051774778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023585     Document Type: Article

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