Constitutive activation of Wnt/β-catenin signaling pathway in migration-active melanoma cells: Role of LEF-1 in melanoma with increased metastatic potential

Biochemical and Biophysical Research Communications

Volumn 288, Issue 1, 2001, Pages 8-15

  Murakami, Takashi ^a   Toda, Sunao ^a   Fujimoto, Mitsuo ^a   Ohtsuki, Mamitaro ^a   Byers, H Randolph ^c   Etoh, Takafumi ^b   Nakagawa, Hidemi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b TOKYO TEISHIN HOSPITAL   (Japan)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell motility; LEF 1; Melanoma; Wnt; catenin

Indexed keywords

APC PROTEIN; BETA CATENIN; GENE PRODUCT; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; BINDING SITE; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; CELL MOTILITY; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; MULTIGENE FAMILY; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

EID: 0035913994     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5719     Document Type: Article

References (47)

1. Propagation and localization of Wnt signaling
2. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
3. Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion
4. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing betacatenin binding to the cell adhesion protein cadherin
5. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
6. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
7. Stabilization of beta-catenin by genetic defects in melanoma cell lines
8. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
9. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function
10. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer
11. Functional interaction of beta-catenin with the transcription factor LEF-1
12. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
13. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
14. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
15. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
16. Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma
17. A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma
18. The biologic forms of malignant melanoma
19. Model predicting survival in stage I melanoma based on tumor progression
20. Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. Time-lapse and image analysis
21. HTLV-1 tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100
22. Migration of human melanoma cells on hyaluronate is related to CD44 expression
23. Role of integrin alpha 2 beta 1 (VLA-2) in the migration of human melanoma cells on laminin and type IV collagen
24. The phagokinetic tracks of 3T3 cells
25. Wnt signaling and cancer
26. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
27. The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors
28. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF
29. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
30. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
31. Biochemical mechanisms of tumor invasion and metastases
32. Tumor cell motility
33. The microenvironment of the tumour-host interface
34. Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1
35. Beta-catenin mutations in human prostate cancer
36. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
37. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
38. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
39. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
40. The mouse fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
41. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
42. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
43. Neural crest development: The interplay between morphogenesis and cell differentiation
44. Neural crest diversification
45. Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture
46. Wnt signaling: A common theme in animal development
47. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development