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Volumn 122, Issue 2, 2011, Pages 476-488

Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal Stromal Cells

Author keywords

Adipogenesis; Bone marrow; Organotin; PPAR ; RXR

Indexed keywords

ABC TRANSPORTER A1; BEXAROTENE; DIBUTYLTIN; FATTY ACID BINDING PROTEIN 4; HETERODIMER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; RETINOID X RECEPTOR; ROSIGLITAZONE; SHORT HAIRPIN RNA; TRIBUTYLTIN; TRIPHENYLTIN;

EID: 80051678891     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr140     Document Type: Article
Times cited : (60)

References (49)
  • 2
    • 14244250617 scopus 로고    scopus 로고
    • Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation
    • Ali, A. A., Weinstein, R. S., Stewart, S. A., Parfitt, A. M., Manolagas, S. C., and Jilka, R. L. (2005). Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146, 1226-1235.
    • (2005) Endocrinology , vol.146 , pp. 1226-1235
    • Ali, A.A.1    Weinstein, R.S.2    Stewart, S.A.3    Parfitt, A.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 3
    • 39049161187 scopus 로고    scopus 로고
    • Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. a review
    • Antizar-Ladislao, B. (2008). Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. a review. Environ. Int. 34, 292-308.
    • (2008) Environ. Int. , vol.34 , pp. 292-308
    • Antizar-Ladislao, B.1
  • 4
    • 44649103929 scopus 로고    scopus 로고
    • TBTC induces adipocyte differentiation in human bone marrow long term culture
    • Carfi, M., Croera, C., Ferrario, D., Campi, V., Bowe, G., Pieters, R., and Gribaldo, L. (2008). TBTC induces adipocyte differentiation in human bone marrow long term culture. Toxicology 249, 11-18.
    • (2008) Toxicology , vol.249 , pp. 11-18
    • Carfi, M.1    Croera, C.2    Ferrario, D.3    Campi, V.4    Bowe, G.5    Pieters, R.6    Gribaldo, L.7
  • 5
    • 0035054634 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle
    • Cha, B. S., Ciaraldi, T. P., Carter, L., Nikoulina, S. E., Mudaliar, S., Mukherjee, R., Paterniti, J. R., Jr., and Henry, R. R. (2001). Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle. Diabetologia 44, 444-452.
    • (2001) Diabetologia , vol.44 , pp. 444-452
    • Cha, B.S.1    Ciaraldi, T.P.2    Carter, L.3    Nikoulina, S.E.4    Mudaliar, S.5    Mukherjee, R.6    Paterniti Jr., J.R.7    Henry, R.R.8
  • 6
    • 0036184457 scopus 로고    scopus 로고
    • Age-related bone loss: old bone, new facts
    • Chan, G. K., and Duque, G. (2002). Age-related bone loss: old bone, new facts. Gerontology 48, 62-71.
    • (2002) Gerontology , vol.48 , pp. 62-71
    • Chan, G.K.1    Duque, G.2
  • 7
    • 8844226036 scopus 로고    scopus 로고
    • Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen
    • Cock, T. A., Back, J., Elefteriou, F., Karsenty, G., Kastner, P., Chan, S., and Auwerx, J. (2004). Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO. Rep. 5, 1007-1012.
    • (2004) EMBO. Rep. , vol.5 , pp. 1007-1012
    • Cock, T.A.1    Back, J.2    Elefteriou, F.3    Karsenty, G.4    Kastner, P.5    Chan, S.6    Auwerx, J.7
  • 8
    • 40849140875 scopus 로고    scopus 로고
    • The contribution of urban runoff to organic contaminant levels in harbour sediments near two Norwegian cities
    • Cornelissen, G., Pettersen, A., Nesse, E., Eek, E., Helland, A., and Breedveld, G. D. (2008). The contribution of urban runoff to organic contaminant levels in harbour sediments near two Norwegian cities. Mar. Pollut. Bull. 56, 565-573.
    • (2008) Mar. Pollut. Bull. , vol.56 , pp. 565-573
    • Cornelissen, G.1    Pettersen, A.2    Nesse, E.3    Eek, E.4    Helland, A.5    Breedveld, G.D.6
  • 9
    • 79951949498 scopus 로고    scopus 로고
    • Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR
    • Cui, H., Okuhira, K., Ohoka, N., Naito, M., Kagechika, H., Hirose, A., and Nishimaki-Mogami, T. (2010). Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha/RXR. Biochem. Pharmacol. 81, 819-824.
    • (2010) Biochem. Pharmacol. , vol.81 , pp. 819-824
    • Cui, H.1    Okuhira, K.2    Ohoka, N.3    Naito, M.4    Kagechika, H.5    Hirose, A.6    Nishimaki-Mogami, T.7
  • 10
    • 40849145708 scopus 로고    scopus 로고
    • Lipid droplets in lipogenesis and lipolysis
    • Ducharme, N. A., and Bickel, P. E. (2008). Lipid droplets in lipogenesis and lipolysis. Endocrinology 149, 942-949.
    • (2008) Endocrinology , vol.149 , pp. 942-949
    • Ducharme, N.A.1    Bickel, P.E.2
  • 11
    • 34547131595 scopus 로고    scopus 로고
    • The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis
    • Feige, J. N., Gelman, L., Rossi, D., Zoete, V., Metivier, R., Tudor, C., Anghel, S. I., Grosdidier, A., Lathion, C., Engelborghs, Y., et al. (2007). The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J. Biol. Chem. 282, 19152-19166.
    • (2007) J. Biol. Chem. , vol.282 , pp. 19152-19166
    • Feige, J.N.1    Gelman, L.2    Rossi, D.3    Zoete, V.4    Metivier, R.5    Tudor, C.6    Anghel, S.I.7    Grosdidier, A.8    Lathion, C.9    Engelborghs, Y.10
  • 12
    • 15944420879 scopus 로고    scopus 로고
    • Occurrence of organotin compounds in house dust in Berlin (Germany)
    • Fromme, H., Mattulat, A., Lahrz, T., and Ruden, H. (2005). Occurrence of organotin compounds in house dust in Berlin (Germany). Chemosphere 58, 1377-1383.
    • (2005) Chemosphere , vol.58 , pp. 1377-1383
    • Fromme, H.1    Mattulat, A.2    Lahrz, T.3    Ruden, H.4
  • 14
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B. R., Kliewer, S. A., Lehmann, J. M., and Morris, D. C. (1996). Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol. Pharmacol. 50, 1087-1094.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4    Rodriguez, B.R.5    Kliewer, S.A.6    Lehmann, J.M.7    Morris, D.C.8
  • 16
    • 0034007387 scopus 로고    scopus 로고
    • A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis
    • Gurnell, M., Wentworth, J. M., Agostini, M., Adams, M., Collingwood, T. N., Provenzano, C., Browne, P. O., Rajanayagam, O., Burris, T. P., Schwabe, J.W., et al. (2000). A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. J. Biol. Chem. 275, 5754-5759.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5754-5759
    • Gurnell, M.1    Wentworth, J.M.2    Agostini, M.3    Adams, M.4    Collingwood, T.N.5    Provenzano, C.6    Browne, P.O.7    Rajanayagam, O.8    Burris, T.P.9    Schwabe, J.W.10
  • 17
    • 67349137873 scopus 로고    scopus 로고
    • Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) gamma by organotin compounds
    • Hiromori, Y., Nishikawa, J., Yoshida, I., Nagase, H., and Nakanishi, T. (2009). Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) gamma by organotin compounds. Chem. Biol. Interact. 180, 238-244.
    • (2009) Chem. Biol. Interact. , vol.180 , pp. 238-244
    • Hiromori, Y.1    Nishikawa, J.2    Yoshida, I.3    Nagase, H.4    Nakanishi, T.5
  • 18
    • 19344361824 scopus 로고    scopus 로고
    • Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells
    • Idres, N., Marill, J., and Chabot, G. G. (2005). Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. Biochem. Pharmacol. 69, 1595-1601.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1595-1601
    • Idres, N.1    Marill, J.2    Chabot, G.G.3
  • 19
    • 77956547390 scopus 로고    scopus 로고
    • Transcriptional profiling identifies functional interactions of TGF beta and PPAR beta/delta signaling: synergistic induction of ANGPTL4 transcription
    • Kaddatz, K., Adhikary, T., Finkernagel, F., Meissner, W., Muller-Brusselbach, S., and Muller, R. (2010). Transcriptional profiling identifies functional interactions of TGF beta and PPAR beta/delta signaling: synergistic induction of ANGPTL4 transcription. J. Biol. Chem. 285, 29469-29479.
    • (2010) J. Biol. Chem. , vol.285 , pp. 29469-29479
    • Kaddatz, K.1    Adhikary, T.2    Finkernagel, F.3    Meissner, W.4    Muller-Brusselbach, S.5    Muller, R.6
  • 20
    • 14944349712 scopus 로고    scopus 로고
    • Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway
    • Kanayama, T., Kobayashi, N., Mamiya, S., Nakanishi, T., and Nishikawa, J. (2005). Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol. Pharmacol. 67, 766-774.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 766-774
    • Kanayama, T.1    Kobayashi, N.2    Mamiya, S.3    Nakanishi, T.4    Nishikawa, J.5
  • 21
    • 77952095681 scopus 로고    scopus 로고
    • Organotin compounds, including butyltins and octyltins, in house dust from Albany, New York, USA
    • Kannan, K., Takahashi, S., Fujiwara, N., Mizukawa, H., and Tanabe, S. (2010). Organotin compounds, including butyltins and octyltins, in house dust from Albany, New York, USA. Arch. Environ. Contam. Toxicol. 58, 901-907.
    • (2010) Arch. Environ. Contam. Toxicol. , vol.58 , pp. 901-907
    • Kannan, K.1    Takahashi, S.2    Fujiwara, N.3    Mizukawa, H.4    Tanabe, S.5
  • 22
  • 23
    • 77249160182 scopus 로고    scopus 로고
    • Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes
    • Kirchner, S., Kieu, T., Chow, C., Casey, S., and Blumberg, B. (2010). Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Mol. Endocrinol. 24, 526-539.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 526-539
    • Kirchner, S.1    Kieu, T.2    Chow, C.3    Casey, S.4    Blumberg, B.5
  • 25
    • 34250847265 scopus 로고    scopus 로고
    • Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone
    • Lazarenko, O. P., Rzonca, S. O., Hogue, W. R., Swain, F. L., Suva, L. J., and Lecka-Czernik, B. (2007). Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone. Endocrinology 148, 2669-2680.
    • (2007) Endocrinology , vol.148 , pp. 2669-2680
    • Lazarenko, O.P.1    Rzonca, S.O.2    Hogue, W.R.3    Swain, F.L.4    Suva, L.J.5    Lecka-Czernik, B.6
  • 27
    • 33846412672 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo
    • Lecka-Czernik, B., Ackert-Bicknell, C., Adamo, M. L., Marmolejos, V., Churchill, G. A., Shockley, K. R., Reid, I. R., Grey, A., and Rosen, C. J. (2007). Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology 148, 903-911.
    • (2007) Endocrinology , vol.148 , pp. 903-911
    • Lecka-Czernik, B.1    Ackert-Bicknell, C.2    Adamo, M.L.3    Marmolejos, V.4    Churchill, G.A.5    Shockley, K.R.6    Reid, I.R.7    Grey, A.8    Rosen, C.J.9
  • 28
    • 18844467411 scopus 로고    scopus 로고
    • T0070907, a selective ligand for peroxisome proliferatoractivated receptor gamma, functions as an antagonist of biochemical and cellular activities
    • Lee, G., Elwood, F., McNally, J., Weiszmann, J., Lindstrom, M., Amaral, K., Nakamura, M., Miao, S., Cao, P., Learned, R. M., et al. (2002). T0070907, a selective ligand for peroxisome proliferatoractivated receptor gamma, functions as an antagonist of biochemical and cellular activities. J. Biol. Chem. 277, 19649-19657.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19649-19657
    • Lee, G.1    Elwood, F.2    McNally, J.3    Weiszmann, J.4    Lindstrom, M.5    Amaral, K.6    Nakamura, M.7    Miao, S.8    Cao, P.9    Learned, R.M.10
  • 30
    • 78049278719 scopus 로고    scopus 로고
    • Retinoid X receptors: common heterodimerization partners with distinct functions
    • Lefebvre, P., Benomar, Y., and Staels, B. (2010). Retinoid X receptors: common heterodimerization partners with distinct functions. Trends. Endocrinol. Metab. 21, 676-683.
    • (2010) Trends. Endocrinol. Metab. , vol.21 , pp. 676-683
    • Lefebvre, P.1    Benomar, Y.2    Staels, B.3
  • 32
    • 58849094131 scopus 로고    scopus 로고
    • Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
    • Loke, Y. K., Singh, S., and Furberg, C. D. (2009). Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. Can. Med. Assoc. J. 180, 32-39.
    • (2009) Can. Med. Assoc. J. , vol.180 , pp. 32-39
    • Loke, Y.K.1    Singh, S.2    Furberg, C.D.3
  • 34
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways
    • Moerman, E. J., Teng, K., Lipschitz, D. A., and Lecka-Czernik, B. (2004). Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 3, 379-389.
    • (2004) Aging Cell , vol.3 , pp. 379-389
    • Moerman, E.J.1    Teng, K.2    Lipschitz, D.A.3    Lecka-Czernik, B.4
  • 36
    • 67650504733 scopus 로고    scopus 로고
    • Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    • Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., and Daley, G. Q. (2009). Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460, 259-263.
    • (2009) Nature , vol.460 , pp. 259-263
    • Naveiras, O.1    Nardi, V.2    Wenzel, P.L.3    Hauschka, P.V.4    Fahey, F.5    Daley, G.Q.6
  • 38
    • 0023884998 scopus 로고
    • Stromal cell lines which support lymphocyte growth: characterization, sensitivity to radiation and responsiveness to growth factors
    • Pietrangeli, C., Hayashi, S.-I., and Kincade, P. (1988). Stromal cell lines which support lymphocyte growth: characterization, sensitivity to radiation and responsiveness to growth factors. Eur. J. Immunol. 18, 863-872.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 863-872
    • Pietrangeli, C.1    Hayashi, S.-I.2    Kincade, P.3
  • 39
    • 31544457103 scopus 로고    scopus 로고
    • Mechanisms of disease: is osteoporosis the obesity of bone?
    • Rosen, C. J., and Bouxsein, M. L. (2006). Mechanisms of disease: is osteoporosis the obesity of bone? Nat. Clin. Pract. Rheumatol. 2, 35-43.
    • (2006) Nat. Clin. Pract. Rheumatol. , vol.2 , pp. 35-43
    • Rosen, C.J.1    Bouxsein, M.L.2
  • 41
    • 0034815710 scopus 로고    scopus 로고
    • Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists
    • Sato, M., Yajima, Y., Kawashima, S., Tanaka, K., and Kagechika, H. (2001). Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists. Biochem. Biophys. Res. Commun. 280, 646-651.
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 646-651
    • Sato, M.1    Yajima, Y.2    Kawashima, S.3    Tanaka, K.4    Kagechika, H.5
  • 42
    • 0031813879 scopus 로고    scopus 로고
    • Transactivation by retinoid X receptor-peroxisome proliferators-activated receptor (PPARc) heterodimers: intermolecular synergy requires only the PPARc hormonedependent activation function
    • Schulman, I. G., Shao, G., and Heyman, R. A. (1998). Transactivation by retinoid X receptor-peroxisome proliferators-activated receptor (PPARc) heterodimers: intermolecular synergy requires only the PPARc hormonedependent activation function. Mol. Cell Biol. 18, 3483-3494.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3483-3494
    • Schulman, I.G.1    Shao, G.2    Heyman, R.A.3
  • 43
    • 65549111189 scopus 로고    scopus 로고
    • Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPARgamma agonist pioglitazone
    • Syversen, U., Stunes, A. K., Gustafsson, B. I., Obrant, K. J., Nordsletten, L., Berge, R., Thommesen, L., and Reseland, J. E. (2009). Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPARgamma agonist pioglitazone. BMC Endocr. Disord. 9, 10.
    • (2009) BMC Endocr. Disord. , vol.9 , pp. 10
    • Syversen, U.1    Stunes, A.K.2    Gustafsson, B.I.3    Obrant, K.J.4    Nordsletten, L.5    Berge, R.6    Thommesen, L.7    Reseland, J.E.8
  • 44
    • 78049342781 scopus 로고    scopus 로고
    • Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells
    • Szeles, L., Poliska, S., Nagy, G., Szatmari, I., Szanto, A., Pap, A., Lindstedt, M., Santegoets, S. J., Ruhl, R., Dezso, B., et al. (2010). Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells. Mol. Endocrinol. 24, 2218-2231.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 2218-2231
    • Szeles, L.1    Poliska, S.2    Nagy, G.3    Szatmari, I.4    Szanto, A.5    Pap, A.6    Lindstedt, M.7    Santegoets, S.J.8    Ruhl, R.9    Dezso, B.10
  • 49
    • 9944244953 scopus 로고    scopus 로고
    • Determination of murine fetal Cyp1a1 and 1b1 expression by real-time fluorescence reverse transcription-polymerase chain reaction
    • Xu, M., and Miller, M. S. (2004). Determination of murine fetal Cyp1a1 and 1b1 expression by real-time fluorescence reverse transcription-polymerase chain reaction. Toxicol. Appl. Pharmacol. 201, 295-302.
    • (2004) Toxicol. Appl. Pharmacol. , vol.201 , pp. 295-302
    • Xu, M.1    Miller, M.S.2


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