Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists

Biochemical and Biophysical Research Communications

Volumn 280, Issue 3, 2001, Pages 646-651

  Sato, Mayumi ^a   Yajima, Yukiko ^a   Kawashima, Seiichi ^a   Tanaka, Keiji ^a   Kagechika, Hiroyuki ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adipocyte differentiation; Heterodimer; PPAR ; RXR ligand; Synergism

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BEXAROTENE; CELL NUCLEUS RECEPTOR; DIMER; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID; RETINOID X RECEPTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG POTENTIATION; LIGAND BINDING; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROADIPOCYTE; RAT; REPORTER GENE; TRANSACTIVATION;

EID: 0034815710     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4172     Document Type: Article

References (20)

1. Preadipocyte differentiation in vitro: Identification of a highly active adipogenic agent
2. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
3. mPPAR γ2 tissue-specific regulator of an adipocyte enhancer
4. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
5. Regulating adipogenesis
6. PPAR γ: Adipose predominant expression and induction early in adipocyte differentiation
7. Orphan nuclear receptors-new ligands and new possibilities
8. Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties
9. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
10. Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells
11. Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells
12. Regulation of retinoidal actions by diazepinylbenzoic acids: Retinoid synergists which activate in RXR-RAR heterodimers
13. Action mechanism of retinoid-synergistic dibenzodiazepines
14. Potent retinoid synergists with a diphenylamine skeleton
15. Establishment of a clonal cell line that differentiation in vitro
16. Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUSCHOP Type II chimeric protein
17. Functional studies of newly synthesized benzoic acid derivatives: Identification of highly potent retinoid-like activity
18. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
19. Unique response pathways are established by allosteric interactions among nuclear hormone receptors
20. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand