Transcriptional profile of diuron-induced toxicity on the urinary bladder of male wistar rats to inform mode of action

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 330-338

  Ihlaseh, Shadia M ^a   Bailey, Kathryn A ^b   Hester, Susan D ^c   Jones, Carlton ^c   Ren, Hongzu ^c   Cardoso, Ana Paula F ^a   Oliveira, Maria Luiza C S ^a   Wolf, Douglas C ^c   de Camargo, João Lauro V ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b IL   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Carcinogenesis; Diuron; Gene expression profiling; Microarray analysis; Urinary bladder

Indexed keywords

DIURON; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER DISEASE; CELL DEATH; CELL METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; EXPOSURE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HISTOLOGY; HYPERPLASIA; MALE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICITY; UROTHELIUM; WISTAR RAT;

ANIMALS; CARCINOGENS; DIET; DIURON; DOSE-RESPONSE RELATIONSHIP, DRUG; HERBICIDES; HYDROGEN-ION CONCENTRATION; HYPERPLASIA; MALE; MICROARRAY ANALYSIS; OXIDATIVE STRESS; RATS; RATS, WISTAR; RNA; TRANSCRIPTION, GENETIC; TRANSCRIPTOME; URINARY BLADDER; UROTHELIUM;

RATTUS; RATTUS NORVEGICUS;

EID: 80051675341     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr108     Document Type: Article

References (32)

1. Chapell, C. I. (1992). A review and biological risk assessment of sodium saccharin. Regul. Toxicol. Pharmacol. 15, 253-270.
2. Chung, C.-J., Huang, C. J., Pu, Y.-S., Su, C.-T., Huang, Y.-K., Chen, Y.-T., and Hsueh, Y.-M. (2008). Urinary 8-hydroxydeoguanosine and urithelial carcinoma risk in low arsenic exposure area. Toxicol. Appl. Pharmacol. 226, 14-21.
3. Cohen, S. M. (1998). Urinary bladder carcinogenesis. Toxicol. Pathol. 26, 121-127.
4. Cohen, S. M., and Lawson, T. A. (1995). Rodent bladder tumors do not always predict for humans. Cancer Lett. 93, 9-16.
5. Cohen, S. M., Ohnishi, T., Arnold, L. L., and Le, X. C. (2007a). Arsenicinduced bladder cancer in an animal model. Toxicol. Appl. Pharmacol. 222, 258-263.
6. Cohen, S. M., Ohnishi, T., Clark, N. M., He, J., and Arnold, L. L. (2007b). Investigations of rodent urinary bladder carcinogens: Collection, processing and evaluation of urine and bladders. Toxicol. Pathol. 35, 337-347.
7. Cox, C. (2003). Herbicide factsheet-Diuron. J. Pestic. Reform. 23, 12-20.
8. Gee, J. (1997). Summary on Toxicologic Data. Diuron. Medical Toxicology Branch. Department of Pesticide Regulation. California Environmental Protection Agency, p.7. Available at: cdpr.ca.gov/docs/risk/toxsums/pdfs/231.pdf Accessed December 10, 2010.
9. Geoffroy, L., Teisseire, H., Couderchet, M., and Vernet, G. (2002). Effect of oxyfluorfen and diuron alone and in mixture on antioxidative enzymes of Scenedesmus obliquus. Pestic. Biochem. Physiol. 72, 178-185.
10. Giacomazzi, S., and Cochet, N. (2004). Environmental impact of diuron transformation: A review. Chemosphere 56, 1021-1032.
11. Hester, S. D., Wolf, D. C., Nesnow, S., and Thai, S.-F. (2006). Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol 34, 879-894.
12. Hodge, H. C., Downs, W. L., Panner, B. S., Smith, D. W., and Maynard, E. A. (1967). Oral toxicity and metabolism of diuron (N-(3,4-dichlorophenyl)-N#,N#-dimethylurea) in rats and dogs. Food Cosmet. Toxicol. 5, 513-531.
13. Iyer, P. (2002). Evidence on the Development and Reproductive Toxicity of Diuron Draft. Reproductive and Cancer Hazard Assessment Section. The Office of Environmental Health Hazard Assessment. California Environmental Protection Agency, Sacramento, CA, p. 43.
14. Kitchin, K. T., and Conolly, R. (2010). Arsenic-induced carcinogenesis-Oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem. Res. Toxicol. 23, 327-335.
15. Klaunig, J. E., Kamendulis, L. M., and Hocevar, B. A. (2010). Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 38, 96-109.
16. La Vecchia, C., and Airoldi, L. (1999). Human bladder cancer: Epidemiological, pathological and mechanistic aspects. IARC Sci. Publ. 147, 139-157.
17. Murta-Nascimento, C., Schmitz-Dräger, B. J., Zeegers, M. P., Steineck, G., Kogevinas, M., Real, F. X., and Malats, N. (2007). Epidemiology of urinary bladder cancer: From tumor development to patient's death. World J. Urol. 25, 285-295.
18. Nascimento, M. G., de Oliveira, M. L. C. S., Lima, A. S., and de Camargo, J. L. V. (2006). Effects of diuron [3-(3,4-dichlorophenyl) -1,1-dimethylurea] on the urinary bladder mucosa of male Wistar rats. Toxicology 224, 66-73.
19. Nesnow, S., Ward, W., Moore, T., Ren, H., and Hester, S. D. (2009). Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. Toxicol. Sci. 110, 68-83.
20. Rocha, M. S., Nascimento, M. G., Cardoso, A. P. F., Lima, P. L. A., Zelandi, E. A., Camargo, J. L. V., and de Oliveira, M. L. C. S. (2010). Cytotoxicity and regenerative proliferation as the mode of action for diuroninduced urothelial carcinogenesis in the rat. Toxicol. Sci. 113, 37-44.
21. Sams, R., II., Wolf, D. C., Ramasamy, S., Ohanian, E., Chen, J., and Lowit, A. (2007). Workshop overview: Arsenic research and risk assessment. Toxicol. Appl. Pharmacol. 222, 245-251.
22. Sanches-Carbayo, M., and Cordon-Cardo, C. (2003). Applications of array technology: Identification of molecular targets in bladder cancer. Br. J. Cancer. 89, 2172-2177.
23. Sanches-Carbayo, M., Socci, N. D., Lozano, J. J., Li, W., Charytonowicz, E., Belbin, T. J., Prystowsky, M. B., Ortiz, A. R., Childs, G., and Cordon-Cardo, C. (2003). Gene discovery in bladder cancer progression using cDNA microarrays. Am. J. Pathol 163, 505-516.
24. Sen, B., Wang, A., Hester, S., Robertson, J. L., and Wolf, D. C. (2005). Gene expression profiling of response to dimethylarsenic acid in female F344 rat urothelium. Toxicology 215, 214-226.
25. Sen, B., Wolf, D. C., Turpaz, Y., Bugrim, A., Retief, J., and Hester, S. D. (2007). Identification of interspecies concordance of mechanisms of arsenicinduced bladder cancer. Toxicol. In Vitro 21, 1513-1529.
26. Tennant, D. A., Duràn, R. V., Boulahbel, H., and Gottlieb, E. (2009). Metabolic transformation in cancer. Carcinogenesis 30, 1269-1280.
27. U.S. Environmental Protection Agency (USEPA). (2003). Registration Eligibility Decision for Diuron List A. Case 0046. Office of Prevention, Pesticides and Toxic Substances, USEPA, Washington, DC, p. 22.
28. U.S. Environmental Protection Agency (USEPA). (2004). Chemicals Evaluated for Carcinogenic Potential. Office of Pesticide Programs, Health Effects Division. Science Information Management Branch, Washington, DC, p. 106.
29. U.S. Environmental Protection Agency (USEPA). (2005). Science Issue Paper: Mode of Carcinogenic Action for Cacodylic Acid (Dimethylarsinic Acid, DMAV) and Recommendations for Dose Response Extrapolation. Health Effects Division, Office of Pesticide Programs, Washington, DC, p. 201.
30. Wei, M., Arnold, L. L., Cano, M., and Cohen, S. M. (2005). Effects of coadministration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicol. Sci. 83, 237-245.
31. Weng, L., Dai, H., Zhan, Y., He, Y., Stepaniants, S. B., and Bassett, D. E. (2006). Rosetta error model for gene expression analysis. Bioinformatics 22, 1111-1121.
32. Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002). Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell. 13, 1977-2000.